The Intuitive Eating Scale-3: Development and psychometric evaluation.

Intuitive eating has been found to protect against disordered eating and preserve well-being. Yet, there are methodological (length), conceptual (inconsideration of medical, value-based, and access-related reasons for food consumption), and psychometric (item wording) concerns with its most common measure, the Intuitive Eating Scale-2 (IES-2). To address these concerns, we developed the IES-3 and investigated its psychometric properties with U.S. community adults. Across three online studies, we evaluated the IES-3's factorial validity using exploratory factor analysis (EFA; Study 1; N = 957; Mage = 36.30), as well as confirmatory factor analysis (CFA), exploratory structural equation modeling (ESEM), bifactor-CFA, and bifactor-ESEM (Study 2; N = 1152; Mage = 40.95), and cross-validated the optimal model (Study 3; N = 884; Mage = 38.54). We examined measurement invariance across samples and time, differential item functioning (age, body mass index [BMI], gender), composite reliability, and validity. Study 1 revealed a 12-item, 4-factor structure (unconditional permission to eat, eating for physical reasons, reliance on hunger and satiety cues, body-food choice congruence). In Study 2, a bifactor-ESEM model with a global intuitive eating factor and four specific factors best fit the data, which was temporally stable across three weeks. This model also had good fit in Study 3 and, across Studies 2 and 3, and was fully invariant and lacked measurement bias in terms of age, gender, and BMI. Associations between latent IES-3 factors and age, gender, and BMI were invariant across Studies 2 and 3. Composite reliability and validity (relationships with disordered eating, embodiment, body image, well-being, and distress; negligible relationship with impression management) of the retained model were also supported. The 12-item IES-3 demonstrates strong psychometric properties in U.S. community adults. Research is now needed using the IES-3 in other cultural contexts and social identity groups.

Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes.

Metformin is the first-line treatment for type 2 diabetes (T2D) in youth but with limited sustained glycemic response. To identify common variants associated with metformin response, we used a genome-wide approach in 506 youth from the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study and examined the relationship between T2D partitioned polygenic scores (pPS), glycemic traits, and metformin response in these youth. Several variants met a suggestive threshold (P < 1 × 10-6), though none including published adult variants reached genome-wide significance. We pursued replication of top nine variants in three cohorts, and rs76195229 in ATRNL1 was associated with worse metformin response in the Metformin Genetics Consortium (n = 7,812), though statistically not being significant after Bonferroni correction (P = 0.06). A higher ß-cell pPS was associated with a lower insulinogenic index (P = 0.02) and C-peptide (P = 0.047) at baseline and higher pPS related to two insulin resistance processes were associated with increased C-peptide at baseline (P = 0.04,0.02). Although pPS were not associated with changes in glycemic traits or metformin response, our results indicate a trend in the association of the ß-cell pPS with reduced ß-cell function over time. Our data show initial evidence for genetic variation associated with metformin response in youth with T2D.

Psychometric evaluation of a revised version of the body appreciation scale-2 for autistic adults (BAS-2A).

Emerging evidence points to unique conceptualisations of positive body image in autistic individuals. However, there are no existing measures of positive body image that have been developed or validated for use with autistic adults. To rectify this, we developed a revised version of the BAS-2 - the BAS-2A - and examined its factorial validity and psychometric properties in a sample of autistic adults from the United Kingdom. Based on the results of exploratory factor analysis and scale purification, we extracted a 12-item, unidimensional model of BAS-2A scores in a first split-subsample (n = 273). Confirmatory factor analysis supported the unidimensional model of BAS-2A scores in a second split-subsample (n = 277). BAS-2A scores presented adequate composite reliability, measurement invariance across gender identity, and patterns of construct validity. For both women and men, BAS-2A scores correlated positively with self-esteem, well-being, quality of life, and adaptive coping, and inversely with dietary restraint, weight/shape overvaluation, body dissatisfaction, and depression. Finally, BAS-2A scores demonstrated incremental validity, predicting self-esteem over-and-above body dissatisfaction. However, temporal stability of the BAS-2A over three weeks was not supported. These results support the BAS-2A as a psychometrically robust measure of body appreciation for use in autistic adults from the United Kingdom.

Translation and validation of a Romanian version of the Breast Appreciation Scale (BrAS).

The 9-item Breast Appreciation Scale (BrAS; Swami et al., 2022) is a recently developed instrument that assesses a woman's positive breasted experiences. To date, however, the psychometric properties of the BrAS have only been investigated in English-speaking women. Here, we report on the translation and validation of a novel, Romanian version of the BrAS. A total of 555 cisgender women from Romania completed a Romanian translation of the BrAS along with additional measures of body image and psychological well-being. Exploratory and confirmatory factor analysis identified a stable unidimensional model of the BrAS, with all nine items retained. Additionally, the Romanian BrAS evidenced complete invariance (i.e., through to latent mean invariance) across mothers and non-mothers, though mothers had higher observed scores than non-mothers. Evidence of convergent, concurrent, and incremental validity was very strong when based on observed BrAS scores, but slightly weaker when based on latent BrAS scores. In particular, greater latent breast appreciation was significantly associated with higher body appreciation, lower breast size dissatisfaction, and higher self-esteem. Overall, these results suggest that the psychometric properties of the Romanian BrAS are robust and that the instrument can be effectively deployed in this linguistic context.

The impact of body image on social cognition: Fear of negative evaluation mediates the relationship between body surveillance and interpersonal distance in women.

Interpersonal distance (IPD) refers to the distance naturally maintained during social interactions, while peripersonal space (PPS) refers to the immediate space surrounding the body, or the space within reaching distance. Previous research has preliminarily indicated that IPD is associated with body image disturbances. We sought to expand extant literature by exploring associations between aspects of positive and negative body image, IPD, and PPS. Seventy-five women from the United Kingdom aged 18-40 years completed measures of body appreciation, body image flexibility, body shame, body surveillance, and body dissatisfaction. IPD boundaries were estimated using a lab-based comfort-distance task, whereas PPS boundaries were estimated using an audio-tactile reaction-time task. Measures of body acceptance by others and fear of negative evaluation were completed as potential mediators. Overall, we identified positive associations between IPD, body surveillance, and fear of negative evaluation, with no statistically significant associations identified between the other indices. The association between active IPD and body surveillance was mediated by fear of negative evaluation, even after controlling for demographic factors. These findings suggest a nuanced relationship between IPD and body image-related factors, highlighting the role of social evaluation anxiety. Future investigations should use experimental designs to further understand these relationships and their implications.

Positive self-beliefs mediate the association between body appreciation and positive mental health.

Previous work has supported direct, positive associations between body appreciation and positive mental health, but has largely neglected to examine possible indirect mechanistic pathways. Here, we propose one relevant mediational pathway, wherein body appreciation is associated with positive mental health via positive self-beliefs (i.e., cognitions that lead individuals to view themselves, their lives, and/or their futures under a positive outlook). To test this hypothesis, we asked an online sample of 496 adults (249 women, 247 men) from the United Kingdom to complete measures of body appreciation, positive self-beliefs, and positive mental health. Participants also completed measures of self-efficacy and resilience, and provided their demographic information. Correlational analysis revealed significant, positive, and strong associations between body appreciation and facets of positive self-beliefs and positive mental health, respectively. Structural equation modelling showed that positive self-beliefs mediated the association between body appreciation and positive mental health after controlling for self-efficacy and resilience. This model was robust across women and men separately, and the mediational effects remained intact in sensitivity and robustness analyses. We discuss ways in which greater body appreciation may help individuals develop and maintain positive self-beliefs, which in turn shape mental health outcomes.

Translation and psychometric properties of a Polish version of the Body Acceptance by Others Scale-2 (BAOS-2).

The 13-item Body Acceptance by Others Scale-2 (BAOS-2) measures generalised perceptions of body acceptance by others. Here, we examined the psychometric properties of a novel Polish translation of the BAOS-2. A sample of 1183 adults (898 women, 285 men; age M = 28.98) from Poland completed a Polish version of the BAOS-2, alongside measures of body appreciation, pressure to conform to appearance ideals, self-compassion, self-esteem, and impression management. Exploratory and confirmatory factor analysis identified a stable unidimensional model of the Polish BAOS-2, with all 13 items retained. Additionally, the Polish BAOS-2 evidenced complete invariance (i.e., through to latent mean invariance) across gender identity. Scores on the BAOS-2 evidenced adequate composite reliability and, in a retest subsample (n = 260), showed complete invariance across four weeks. Evidence of convergent, criterion-related, discriminant, and incremental validity was very strong when based on observed BAOS-2 scores, but weaker when based on latent BAOS-2 scores. Whether examined at the observed or latent level, greater body acceptance by others was consistently and strongly associated with higher body appreciation. These results suggest that the psychometric properties of the Polish BAOS-2 are robust and that this instrument can be confidently utilised in future research with Polish adults.

Heightened interoception in adults with fibromyalgia.

Previous research suggests that the processing of internal body sensations (interoception) affects how we experience pain. Some evidence suggests that people with fibromyalgia syndrome (FMS) - a condition characterised by chronic pain and fatigue - may have altered interoceptive processing. However, extant findings are inconclusive, and some tasks previously used to measure interoception are of questionable validity. Here, we used an alternative measure - the Phase Adjustment Task (PAT) - to examine cardiac interoceptive accuracy in adults with FMS. We examined: (i) the tolerability of the PAT in an FMS sample (N = 154); (ii) if there are differences in facets of interoception (PAT performance, PAT-related confidence, and scores on the Private Body Consciousness Scale) between an FMS sample and an age- and gender-matched pain-free sample (N = 94); and (iii) if subgroups of participants with FMS are identifiable according to interoceptive accuracy levels. We found the PAT was tolerable in the FMS sample, with additional task breaks and a recommended hand posture. The FMS sample were more likely to be classified as 'interoceptive' on the PAT, and had significantly higher self-reported interoception compared to the pain-free sample. Within the FMS sample, we identified a subgroup who demonstrated very strong evidence of being interoceptive, and concurrently had lower fibromyalgia symptom impact (although the effect size was small). Conversely, self-reported interoception was positively correlated with FMS symptom severity and impact. Overall, interoception may be an important factor to consider in understanding and managing FMS symptoms. We recommend future longitudinal work to better understand associations between fluctuating FMS symptoms and interoception.

Genetic architecture and biology of youth-onset type 2 diabetes.

The prevalence of youth-onset type 2 diabetes (T2D) and childhood obesity has been rising steadily1, producing a growing public health concern1 that disproportionately affects minority groups2. The genetic basis of youth-onset T2D and its relationship to other forms of diabetes are unclear3. Here we report a detailed genetic characterization of youth-onset T2D by analysing exome sequences and common variant associations for 3,005 individuals with youth-onset T2D and 9,777 adult control participants matched for ancestry, including both males and females. We identify monogenic diabetes variants in 2.4% of individuals and three exome-wide significant (P < 2.6 × 10-6) gene-level associations (HNF1A, MC4R, ATXN2L). Furthermore, we report rare variant association enrichments within 25 gene sets related to obesity, monogenic diabetes and ß-cell function. Many youth-onset T2D associations are shared with adult-onset T2D, but genetic risk factors of all frequencies-and rare variants in particular-are enriched within youth-onset T2D cases (5.0-fold increase in the rare variant and 3.4-fold increase in common variant genetic liability relative to adult-onset cases). The clinical presentation of participants with youth-onset T2D is influenced in part by the frequency of genetic risk factors within each individual. These findings portray youth-onset T2D as a heterogeneous disease situated on a spectrum between monogenic diabetes and adult-onset T2D.