Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

CRISPR/Cas9-Mediated Gene Editing in Human iPSC-Derived Macrophage Reveals Lysosomal Acid Lipase Function in Human Macrophages-Brief Report.

Zhang, Hanrui; Shi, Jianting; Hachet, Melanie A; Xue, Chenyi; Bauer, Robert C; Jiang, Hongfeng; Li, Wenjun; Tohyama, Junichiro; Millar, John; Billheimer, Jeffrey; Phillips, Michael C; Razani, Babak; Rader, Daniel J; Reilly, Muredach P.

Arterioscler Thromb Vasc Biol ; 37(11): 2156-2160, 2017 11.

Artigo em Inglês | MEDLINE | ID: mdl-28882870

2.

Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport.

Kuwano, Takashi; Bi, Xin; Cipollari, Eleonora; Yasuda, Tomoyuki; Lagor, William R; Szapary, Hannah J; Tohyama, Junichiro; Millar, John S; Billheimer, Jeffrey T; Lyssenko, Nicholas N; Rader, Daniel J.

J Lipid Res ; 58(4): 731-741, 2017 04.

Artigo em Inglês | MEDLINE | ID: mdl-28137768

3.

Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis.

Patel, Kevin M; Strong, Alanna; Tohyama, Junichiro; Jin, Xueting; Morales, Carlos R; Billheimer, Jeffery; Millar, John; Kruth, Howard; Rader, Daniel J.

Circ Res ; 116(5): 789-96, 2015 Feb 27.

Artigo em Inglês | MEDLINE | ID: mdl-25593281

4.

Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice.

Bauer, Robert C; Tohyama, Junichiro; Cui, Jian; Cheng, Lan; Yang, Jifu; Zhang, Xuan; Ou, Kristy; Paschos, Georgios K; Zheng, X Long; Parmacek, Michael S; Rader, Daniel J; Reilly, Muredach P.

Circulation ; 131(13): 1202-1213, 2015 Mar 31.

Artigo em Inglês | MEDLINE | ID: mdl-25712206

5.

Genetic ablation of Adamts13 gene dramatically accelerates the formation of early atherosclerosis in a murine model.

Jin, Sheng-Yu; Tohyama, Junichiro; Bauer, Robert C; Cao, Na Nora; Rader, Daniel J; Zheng, X Long.

Arterioscler Thromb Vasc Biol ; 32(8): 1817-23, 2012 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-22652598

6.

Peroxisome proliferator-activated receptor-α activation promotes macrophage reverse cholesterol transport through a liver X receptor-dependent pathway.

Nakaya, Kazuhiro; Tohyama, Junichiro; Naik, Snehal U; Tanigawa, Hiroyuki; MacPhee, Colin; Billheimer, Jeffrey T; Rader, Daniel J.

Arterioscler Thromb Vasc Biol ; 31(6): 1276-82, 2011 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-21441141

7.

Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion.

Choa, Ruth; Tohyama, Junichiro; Wada, Shogo; Meng, Hu; Hu, Jian; Okumura, Mariko; May, Rebecca M; Robertson, Tanner F; Pai, Ruth-Anne Langan; Nace, Arben; Hopkins, Christian; Jacobsen, Elizabeth A; Haldar, Malay; FitzGerald, Garret A; Behrens, Edward M; Minn, Andy J; Seale, Patrick; Cotsarelis, George; Kim, Brian; Seykora, John T; Li, Mingyao; Arany, Zoltan; Kambayashi, Taku.

Science ; 373(6554)2021 07 30.

Artigo em Inglês | MEDLINE | ID: mdl-34326208

8.

Lecithin: cholesterol acyltransferase expression has minimal effects on macrophage reverse cholesterol transport in vivo.

Tanigawa, Hiroyuki; Billheimer, Jeffrey T; Tohyama, Jun-ichiro; Fuki, Ilia V; Ng, Dominic S; Rothblat, George H; Rader, Daniel J.

Circulation ; 120(2): 160-9, 2009 Jul 14.

Artigo em Inglês | MEDLINE | ID: mdl-19564558

9.

Increased protein nitration burden in the atherosclerotic lesions and plasma of apolipoprotein A-I deficient mice.

Parastatidis, Ioannis; Thomson, Leonor; Fries, Diana M; Moore, Ryan E; Tohyama, Junichiro; Fu, Xiaoming; Hazen, Stanley L; Heijnen, Harry F G; Dennehy, Michelle K; Liebler, Daniel C; Rader, Daniel J; Ischiropoulos, Harry.

Circ Res ; 101(4): 368-76, 2007 Aug 17.

Artigo em Inglês | MEDLINE | ID: mdl-17615369

10.

Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport.

Tanigawa, Hiroyuki; Billheimer, Jeffrey T; Tohyama, Jun-ichiro; Zhang, YuZhen; Rothblat, George; Rader, Daniel J.

Circulation ; 116(11): 1267-73, 2007 Sep 11.

Artigo em Inglês | MEDLINE | ID: mdl-17709636

11.

Increased remnant lipoprotein in patients with coronary artery disease--evaluation utilizing a newly developed remnant assay, remnant lipoproteins cholesterol homogenous assay (RemL-C).

Nakada, Yoshinobu; Kurosawa, Hideo; Tohyama, Jun-Ichiro; Inoue, Yae; Ikewaki, Katsunori.

J Atheroscler Thromb ; 14(2): 56-64, 2007 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-17485889

12.

Effects of bezafibrate on lipoprotein subclasses and inflammatory markers in patients with hypertriglyceridemia--a nuclear magnetic resonance study.

Ikewaki, Katsunori; Noma, Kenji; Tohyama, Jun-Ichiro; Kido, Toshimi; Mochizuki, Seibu.

Int J Cardiol ; 101(3): 441-7, 2005 Jun 08.

Artigo em Inglês | MEDLINE | ID: mdl-15907413

13.

Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects.

Millar, John S; Reyes-Soffer, Gissette; Jumes, Patricia; Dunbar, Richard L; deGoma, Emil M; Baer, Amanda L; Karmally, Wahida; Donovan, Daniel S; Rafeek, Hashmi; Pollan, Laura; Tohyama, Junichiro; Johnson-Levonas, Amy O; Wagner, John A; Holleran, Stephen; Obunike, Joseph; Liu, Yang; Ramakrishnan, Rajasekhar; Lassman, Michael E; Gutstein, David E; Ginsberg, Henry N; Rader, Daniel J.

J Clin Invest ; 125(6): 2510-22, 2015 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-25961461

14.

A novel two nucleotide deletion in the apolipoprotein A-I gene, apoA-I Shinbashi, associated with high density lipoprotein deficiency, corneal opacities, planar xanthomas, and premature coronary artery disease.

Ikewaki, Katsunori; Matsunaga, Akira; Han, Hua; Watanabe, Hisayuki; Endo, Akira; Tohyama, Jun-ichiro; Kuno, Mamoru; Mogi, Jun-ichi; Sugimoto, Ken-ichi; Tada, Norio; Sasaki, Jun; Mochizuki, Seibu.

Atherosclerosis ; 172(1): 39-45, 2004 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-14709355

15.

Fenofibrate effectively reduces remnants, and small dense LDL, and increases HDL particle number in hypertriglyceridemic men - a nuclear magnetic resonance study.

Ikewaki, Katsunori; Tohyama, Jun-ichiro; Nakata, Yoshinobu; Wakikawa, Tomohiko; Kido, Toshimi; Mochizuki, Seibu.

J Atheroscler Thromb ; 11(5): 278-85, 2004.

Artigo em Inglês | MEDLINE | ID: mdl-15557710

16.

[Dyslipidemia in metabolic syndrome].

Ikewaki, Katsunori; Tohyama, Jun-ichiro.

Nihon Rinsho ; 62(6): 1099-103, 2004 Jun.

Artigo em Japonês | MEDLINE | ID: mdl-15206147

17.

Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects.

Millar, John S; Reyes-Soffer, Gissette; Jumes, Patricia; Dunbar, Richard L; deGoma, Emil M; Baer, Amanda L; Karmally, Wahida; Donovan, Daniel S; Rafeek, Hashmi; Pollan, Laura; Tohyama, Junichiro; Johnson-Levonas, Amy O; Wagner, John A; Holleran, Stephen; Obunike, Joseph; Liu, Yang; Ramakrishnan, Rajasekhar; Lassman, Michael E; Gutstein, David E; Ginsberg, Henry N; Rader, Daniel J.

J Clin Invest ; 126(4): 1603-4, 2016 Apr 01.

Artigo em Inglês | MEDLINE | ID: mdl-27035815

18.

Effects of nevirapine and efavirenz on HDL cholesterol levels and reverse cholesterol transport in mice.

Tohyama, Junichiro; Billheimer, Jeffrey T; Fuki, Ilia V; Rothblat, George H; Rader, Daniel J; Millar, John S.

Atherosclerosis ; 204(2): 418-23, 2009 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-18990393

19.

Effects of atorvastatin on nuclear magnetic resonance-defined lipoprotein subclasses and inflammatory markers in patients with hypercholesterolemia.

Ikewaki, Katsunori; Terao, Yoshio; Ozasa, Hideki; Nakada, Yoshinobu; Tohyama, Jun-ichiro; Inoue, Yae; Yoshimura, Michihiro.

J Atheroscler Thromb ; 16(1): 51-6, 2009 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-19261998

20.

Coronary artery spasm discovered in thorough examination of perioperative VT in a 26-year-old Japanese male.

O-uchi, Jin; Komukai, Kimiaki; Tohyama, Jun-ichiro; Inada, Keiichi; Iwano, Keiji; Yamane, Teiichi; Shibata, Takahiro; Mochizuki, Seibu.

Jpn Heart J ; 44(6): 1021-6, 2003 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-14711196

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CRISPR/Cas9-Mediated Gene Editing in Human iPSC-Derived Macrophage Reveals Lysosomal Acid Lipase Function in Human Macrophages-Brief Report.

Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport.

Macrophage sortilin promotes LDL uptake, foam cell formation, and atherosclerosis.

Knockout of Adamts7, a novel coronary artery disease locus in humans, reduces atherosclerosis in mice.

Genetic ablation of Adamts13 gene dramatically accelerates the formation of early atherosclerosis in a murine model.

Peroxisome proliferator-activated receptor-α activation promotes macrophage reverse cholesterol transport through a liver X receptor-dependent pathway.

Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion.

Lecithin: cholesterol acyltransferase expression has minimal effects on macrophage reverse cholesterol transport in vivo.

Increased protein nitration burden in the atherosclerotic lesions and plasma of apolipoprotein A-I deficient mice.

Expression of cholesteryl ester transfer protein in mice promotes macrophage reverse cholesterol transport.

Increased remnant lipoprotein in patients with coronary artery disease--evaluation utilizing a newly developed remnant assay, remnant lipoproteins cholesterol homogenous assay (RemL-C).

Effects of bezafibrate on lipoprotein subclasses and inflammatory markers in patients with hypertriglyceridemia--a nuclear magnetic resonance study.

Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects.

A novel two nucleotide deletion in the apolipoprotein A-I gene, apoA-I Shinbashi, associated with high density lipoprotein deficiency, corneal opacities, planar xanthomas, and premature coronary artery disease.

Fenofibrate effectively reduces remnants, and small dense LDL, and increases HDL particle number in hypertriglyceridemic men - a nuclear magnetic resonance study.

[Dyslipidemia in metabolic syndrome].

Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects.

Effects of nevirapine and efavirenz on HDL cholesterol levels and reverse cholesterol transport in mice.

Effects of atorvastatin on nuclear magnetic resonance-defined lipoprotein subclasses and inflammatory markers in patients with hypercholesterolemia.

Coronary artery spasm discovered in thorough examination of perioperative VT in a 26-year-old Japanese male.