Detalhe da pesquisa
1.
Design, synthesis and biological evaluation of novel quinazoline derivatives as immune checkpoint inhibitors.
Bioorg Med Chem Lett
; 108: 129796, 2024 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38754563
2.
Design, synthesis and evaluation the bioactivities of novel 1,3-dimethyl-6-amino-1H-indazole derivatives as anticancer agents.
Bioorg Med Chem
; 90: 117377, 2023 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37352576
3.
Impact of the Astaxanthin, Betanin, and EGCG Compounds on Small Oligomers of Amyloid Aß40 Peptide.
J Chem Inf Model
; 60(3): 1399-1408, 2020 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32105466
4.
New Acetohydrazides Incorporating 2-Oxoindoline and 4-Oxoquinazoline: Synthesis and Evaluation of Cytotoxicity and Caspase Activation Activity.
Chem Biodivers
; 17(3): e1900670, 2020 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-31943757
5.
Structure-activity relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of Mammalian target of rapamycin complex 1 (mTORC1).
Bioorg Med Chem
; 27(6): 1099-1109, 2019 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30755350
6.
Novel 3,4-dihydro-4-oxoquinazoline-based acetohydrazides: Design, synthesis and evaluation of antitumor cytotoxicity and caspase activation activity.
Bioorg Chem
; 92: 103202, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31479984
7.
(E)-N'-Arylidene-2-(4-oxoquinazolin-4(3H)-yl) acetohydrazides: Synthesis and evaluation of antitumor cytotoxicity and caspase activation activity.
J Enzyme Inhib Med Chem
; 34(1): 465-478, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30734614
8.
Potent human glutaminyl cyclase inhibitors as potential anti-Alzheimer's agents: Structure-activity relationship study of Arg-mimetic region.
Bioorg Med Chem
; 26(5): 1035-1049, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29398442
9.
Structure-activity relationship investigation of Phe-Arg mimetic region of human glutaminyl cyclase inhibitors.
Bioorg Med Chem
; 26(12): 3133-3144, 2018 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-29705377
10.
N'-[(E)-Arylidene]-2-(2,3-dihydro-3-oxo-4H-1,4-benzoxazin-4-yl)-acetohydrazides: Synthesis and Evaluation of Caspase Activation Activity and Cytotoxicity.
Chem Biodivers
; 15(10): e1800322, 2018 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-30054973
11.
Discovery of simplified leucyladenylate sulfamates as novel leucyl-tRNA synthetase (LRS)-targeted mammalian target of rapamycin complex 1 (mTORC1) inhibitors.
Bioorg Med Chem
; 25(15): 4145-4152, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28625715
12.
α-Substituted 2-(3-fluoro-4-methylsulfonamidophenyl)acetamides as potent TRPV1 antagonists.
Bioorg Med Chem Lett
; 25(11): 2326-30, 2015 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25937016
13.
α-Methylated simplified resiniferatoxin (sRTX) thiourea analogues as potent and stereospecific TRPV1 antagonists.
Bioorg Med Chem Lett
; 24(12): 2685-8, 2014 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24794110
14.
2-Aryl substituted pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as highly potent TRPV1 antagonists.
Bioorg Med Chem Lett
; 24(16): 4044-7, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25011915
15.
Silver nanoparticles alter the dimerization of Aß42 studied by REMD simulations.
RSC Adv
; 14(21): 15112-15119, 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38720971
16.
Natural compounds inhibit Monkeypox virus methyltransferase VP39 in silico studies.
J Biomol Struct Dyn
; : 1-9, 2024 Feb 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38419271
17.
Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template.
Bioorg Med Chem
; 21(13): 3821-30, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23643900
18.
TRPV1 antagonist with high analgesic efficacy: 2-Thio pyridine C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides.
Bioorg Med Chem
; 21(21): 6657-64, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24035514
19.
G-TRACE: rapid Gal4-based cell lineage analysis in Drosophila.
Nat Methods
; 6(8): 603-5, 2009 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-19633663
20.
Searching for AChE inhibitors from natural compounds by using machine learning and atomistic simulations.
J Mol Graph Model
; 115: 108230, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35661591