Detalhe da pesquisa
1.
High-Throughput Compound Quality Assessment with High-Mass-Resolution Acoustic Ejection Mass Spectrometry: An Automatic Data Processing Toolkit.
Anal Chem
; 96(21): 8381-8389, 2024 May 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38750648
2.
Acoustic Ejection Mass Spectrometry for High-Throughput Analysis.
Anal Chem
; 93(31): 10850-10861, 2021 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34320311
3.
In Vitro-In Vivo Extrapolation of Key Transporter Activity at the Blood-Brain Barrier.
Drug Metab Dispos
; 47(4): 405-411, 2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30683809
4.
Novel Multiplexed High Throughput Screening of Selective Inhibitors for Drug-Metabolizing Enzymes Using Human Hepatocytes.
AAPS J
; 26(3): 36, 2024 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38546903
5.
Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex.
RSC Med Chem
; 15(3): 1066-1071, 2024 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38516600
6.
Aldehyde oxidase 1 (AOX1) in human liver cytosols: quantitative characterization of AOX1 expression level and activity relationship.
Drug Metab Dispos
; 41(10): 1797-804, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23857892
7.
Species independence in brain tissue binding using brain homogenates.
Drug Metab Dispos
; 39(7): 1270-7, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21474681
8.
A Comparison of Two Stability Proteomics Methods for Drug Target Identification in OnePot 2D Format.
ACS Chem Biol
; 16(8): 1445-1455, 2021 08 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34374519
9.
Refining the in vitro and in vivo critical parameters for P-glycoprotein, [I]/IC50 and [I2]/IC50, that allow for the exclusion of drug candidates from clinical digoxin interaction studies.
Mol Pharm
; 7(2): 398-411, 2010 Apr 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20025245
10.
Ultra-High-Throughput Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry for Parallel Medicinal Chemistry.
ACS Med Chem Lett
; 11(6): 1101-1110, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32550988
11.
The effect of breast cancer resistance protein and P-glycoprotein on the brain penetration of flavopiridol, imatinib mesylate (Gleevec), prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic acid (PF-407288) in mice.
Drug Metab Dispos
; 37(5): 946-55, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19225039
12.
In silico modeling of nonspecific binding to human liver microsomes.
Drug Metab Dispos
; 36(10): 2130-5, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18606744
13.
In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system.
Drug Metab Dispos
; 36(2): 268-75, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17962372
14.
Fluorescently labeled analogues of dofetilide as high-affinity fluorescence polarization ligands for the human ether-a-go-go-related gene (hERG) channel.
J Med Chem
; 50(13): 2931-41, 2007 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-17536794
15.
Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design.
Eur J Med Chem
; 57: 441-8, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-22840492
16.
Development of a new permeability assay using low-efflux MDCKII cells.
J Pharm Sci
; 100(11): 4974-85, 2011 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-21766308
17.
Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes.
ACS Chem Neurosci
; 1(6): 420-34, 2010 Jun 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-22778836
18.
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
J Med Chem
; 53(3): 1098-108, 2010 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20070106
19.
N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" to assess the impact of efflux transporters on oral drug absorption in the rat.
J Pharm Sci
; 98(12): 4914-27, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19373887
20.
Physicochemical determinants of human renal clearance.
J Med Chem
; 52(15): 4844-52, 2009 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-19445515