Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration.

Dileep, Vishnu; Boix, Carles A; Mathys, Hansruedi; Marco, Asaf; Welch, Gwyneth M; Meharena, Hiruy S; Loon, Anjanet; Jeloka, Ritika; Peng, Zhuyu; Bennett, David A; Kellis, Manolis; Tsai, Li-Huei.

Cell ; 186(20): 4404-4421.e20, 2023 09 28.

Artigo em Inglês | MEDLINE | ID: mdl-37774679

2.

Human microglial state dynamics in Alzheimer's disease progression.

Sun, Na; Victor, Matheus B; Park, Yongjin P; Xiong, Xushen; Scannail, Aine Ni; Leary, Noelle; Prosper, Shaniah; Viswanathan, Soujanya; Luna, Xochitl; Boix, Carles A; James, Benjamin T; Tanigawa, Yosuke; Galani, Kyriaki; Mathys, Hansruedi; Jiang, Xueqiao; Ng, Ayesha P; Bennett, David A; Tsai, Li-Huei; Kellis, Manolis.

Cell ; 186(20): 4386-4403.e29, 2023 09 28.

Artigo em Inglês | MEDLINE | ID: mdl-37774678

3.

Epigenomic dissection of Alzheimer's disease pinpoints causal variants and reveals epigenome erosion.

Xiong, Xushen; James, Benjamin T; Boix, Carles A; Park, Yongjin P; Galani, Kyriaki; Victor, Matheus B; Sun, Na; Hou, Lei; Ho, Li-Lun; Mantero, Julio; Scannail, Aine Ni; Dileep, Vishnu; Dong, Weixiu; Mathys, Hansruedi; Bennett, David A; Tsai, Li-Huei; Kellis, Manolis.

Cell ; 186(20): 4422-4437.e21, 2023 09 28.

Artigo em Inglês | MEDLINE | ID: mdl-37774680

4.

Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer's disease pathology.

Mathys, Hansruedi; Peng, Zhuyu; Boix, Carles A; Victor, Matheus B; Leary, Noelle; Babu, Sudhagar; Abdelhady, Ghada; Jiang, Xueqiao; Ng, Ayesha P; Ghafari, Kimia; Kunisky, Alexander K; Mantero, Julio; Galani, Kyriaki; Lohia, Vanshika N; Fortier, Gabrielle E; Lotfi, Yasmine; Ivey, Jason; Brown, Hannah P; Patel, Pratham R; Chakraborty, Nehal; Beaudway, Jacob I; Imhoff, Elizabeth J; Keeler, Cameron F; McChesney, Maren M; Patel, Haishal H; Patel, Sahil P; Thai, Megan T; Bennett, David A; Kellis, Manolis; Tsai, Li-Huei.

Cell ; 186(20): 4365-4385.e27, 2023 09 28.

Artigo em Inglês | MEDLINE | ID: mdl-37774677

5.

Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition.

Martorell, Anthony J; Paulson, Abigail L; Suk, Ho-Jun; Abdurrob, Fatema; Drummond, Gabrielle T; Guan, Webster; Young, Jennie Z; Kim, David Nam-Woo; Kritskiy, Oleg; Barker, Scarlett J; Mangena, Vamsi; Prince, Stephanie M; Brown, Emery N; Chung, Kwanghun; Boyden, Edward S; Singer, Annabelle C; Tsai, Li-Huei.

Cell ; 177(2): 256-271.e22, 2019 04 04.

Artigo em Inglês | MEDLINE | ID: mdl-30879788

6.

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields.

Grossman, Nir; Bono, David; Dedic, Nina; Kodandaramaiah, Suhasa B; Rudenko, Andrii; Suk, Ho-Jun; Cassara, Antonino M; Neufeld, Esra; Kuster, Niels; Tsai, Li-Huei; Pascual-Leone, Alvaro; Boyden, Edward S.

Cell ; 169(6): 1029-1041.e16, 2017 Jun 01.

Artigo em Inglês | MEDLINE | ID: mdl-28575667

7.

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes.

Madabhushi, Ram; Gao, Fan; Pfenning, Andreas R; Pan, Ling; Yamakawa, Satoko; Seo, Jinsoo; Rueda, Richard; Phan, Trongha X; Yamakawa, Hidekuni; Pao, Ping-Chieh; Stott, Ryan T; Gjoneska, Elizabeta; Nott, Alexi; Cho, Sukhee; Kellis, Manolis; Tsai, Li-Huei.

Cell ; 161(7): 1592-605, 2015 Jun 18.

Artigo em Inglês | MEDLINE | ID: mdl-26052046

8.

Multisensory gamma stimulation promotes glymphatic clearance of amyloid.

Murdock, Mitchell H; Yang, Cheng-Yi; Sun, Na; Pao, Ping-Chieh; Blanco-Duque, Cristina; Kahn, Martin C; Kim, TaeHyun; Lavoie, Nicolas S; Victor, Matheus B; Islam, Md Rezaul; Galiana, Fabiola; Leary, Noelle; Wang, Sidney; Bubnys, Adele; Ma, Emily; Akay, Leyla A; Sneve, Madison; Qian, Yong; Lai, Cuixin; McCarthy, Michelle M; Kopell, Nancy; Kellis, Manolis; Piatkevich, Kiryl D; Boyden, Edward S; Tsai, Li-Huei.

Nature ; 627(8002): 149-156, 2024 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-38418876

9.

Calcineurin dephosphorylates topoisomerase IIß and regulates the formation of neuronal-activity-induced DNA breaks.

Delint-Ramirez, Ilse; Konada, Lahiri; Heady, Lance; Rueda, Richard; Jacome, Alvaro Sebastian Vaca; Marlin, Eric; Marchioni, Charlotte; Segev, Amir; Kritskiy, Oleg; Yamakawa, Satoko; Reiter, Andrew H; Tsai, Li-Huei; Madabhushi, Ram.

Mol Cell ; 82(20): 3794-3809.e8, 2022 10 20.

Artigo em Inglês | MEDLINE | ID: mdl-36206766

10.

Activity-dependent p25 generation regulates synaptic plasticity and Aß-induced cognitive impairment.

Seo, Jinsoo; Giusti-Rodríguez, Paola; Zhou, Ying; Rudenko, Andrii; Cho, Sukhee; Ota, Kristie T; Park, Christine; Patzke, Holger; Madabhushi, Ram; Pan, Ling; Mungenast, Alison E; Guan, Ji-Song; Delalle, Ivana; Tsai, Li-Huei.

Cell ; 157(2): 486-498, 2014 Apr 10.

Artigo em Inglês | MEDLINE | ID: mdl-24725413

11.

Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories.

Gräff, Johannes; Joseph, Nadine F; Horn, Meryl E; Samiei, Alireza; Meng, Jia; Seo, Jinsoo; Rei, Damien; Bero, Adam W; Phan, Trongha X; Wagner, Florence; Holson, Edward; Xu, Jinbin; Sun, Jianjun; Neve, Rachael L; Mach, Robert H; Haggarty, Stephen J; Tsai, Li-Huei.

Cell ; 156(1-2): 261-76, 2014 Jan 16.

Artigo em Inglês | MEDLINE | ID: mdl-24439381

12.

Cell of all trades: oligodendrocyte precursor cells in synaptic, vascular, and immune function.

Akay, Leyla Anne; Effenberger, Audrey H; Tsai, Li-Huei.

Genes Dev ; 35(3-4): 180-198, 2021 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-33526585

13.

Single-cell dissection of the human brain vasculature.

Garcia, Francisco J; Sun, Na; Lee, Hyeseung; Godlewski, Brianna; Mathys, Hansruedi; Galani, Kyriaki; Zhou, Blake; Jiang, Xueqiao; Ng, Ayesha P; Mantero, Julio; Tsai, Li-Huei; Bennett, David A; Sahin, Mustafa; Kellis, Manolis; Heiman, Myriam.

Nature ; 603(7903): 893-899, 2022 03.

Artigo em Inglês | MEDLINE | ID: mdl-35158371

14.

APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes.

Blanchard, Joel W; Akay, Leyla Anne; Davila-Velderrain, Jose; von Maydell, Djuna; Mathys, Hansruedi; Davidson, Shawn M; Effenberger, Audrey; Chen, Chih-Yu; Maner-Smith, Kristal; Hajjar, Ihab; Ortlund, Eric A; Bula, Michael; Agbas, Emre; Ng, Ayesha; Jiang, Xueqiao; Kahn, Martin; Blanco-Duque, Cristina; Lavoie, Nicolas; Liu, Liwang; Reyes, Ricardo; Lin, Yuan-Ta; Ko, Tak; R'Bibo, Lea; Ralvenius, William T; Bennett, David A; Cam, Hugh P; Kellis, Manolis; Tsai, Li-Huei.

Nature ; 611(7937): 769-779, 2022 11.

Artigo em Inglês | MEDLINE | ID: mdl-36385529

15.

A Developmental Switch in Microglial HDAC Function.

Mathys, Hansruedi; Penney, Jay; Tsai, Li-Huei.

Immunity ; 48(3): 476-478, 2018 03 20.

Artigo em Inglês | MEDLINE | ID: mdl-29562197

16.

Mitigating aberrant Cdk5 activation alleviates mitochondrial defects and motor neuron disease symptoms in spinal muscular atrophy.

Miller, Nimrod; Xu, Zhaofa; Quinlan, Katharina A; Ji, Amy; McGivern, Jered V; Feng, Zhihua; Shi, Han; Ko, Chien-Ping; Tsai, Li-Huei; Heckman, Charles J; Ebert, Allison D; Ma, Yongchao C.

Proc Natl Acad Sci U S A ; 120(47): e2300308120, 2023 Nov 21.

Artigo em Inglês | MEDLINE | ID: mdl-37976261

17.

A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes.

Pao, Ping-Chieh; Seo, Jinsoo; Lee, Audrey; Kritskiy, Oleg; Patnaik, Debasis; Penney, Jay; Raju, Ravikiran M; Geigenmuller, Ute; Silva, M Catarina; Lucente, Diane E; Gusella, James F; Dickerson, Bradford C; Loon, Anjanet; Yu, Margaret X; Bula, Michael; Yu, Melody; Haggarty, Stephen J; Tsai, Li-Huei.

Proc Natl Acad Sci U S A ; 120(16): e2217864120, 2023 04 18.

Artigo em Inglês | MEDLINE | ID: mdl-37043533

18.

Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease.

Vance, Jeffery M; Farrer, Lindsay A; Huang, Yadong; Cruchaga, Carlos; Hyman, Bradley T; Pericak-Vance, Margaret A; Goate, Alison M; Greicius, Michael D; Griswold, Anthony J; Haines, Jonathan L; Tcw, Julia; Schellenberg, Gerard D; Tsai, Li-Huei; Herz, Joachim; Holtzman, David M.

Ann Neurol ; 95(4): 625-634, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38180638

19.

MicroTUB(B3)ules and brain development.

Singh, Karun K; Tsai, Li-Huei.

Cell ; 140(1): 30-2, 2010 Jan 08.

Artigo em Inglês | MEDLINE | ID: mdl-20085703

20.

Author Correction: Single-cell transcriptomic analysis of Alzheimer's disease.

Mathys, Hansruedi; Davila-Velderrain, Jose; Peng, Zhuyu; Gao, Fan; Mohammadi, Shahin; Young, Jennie Z; Menon, Madhvi; He, Liang; Abdurrob, Fatema; Jiang, Xueqiao; Martorell, Anthony J; Ransohoff, Richard M; Hafler, Brian P; Bennett, David A; Kellis, Manolis; Tsai, Li-Huei.

Nature ; 571(7763): E1, 2019 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-31209304

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