Detalhe da pesquisa
1.
Once-daily oral small-molecule glucagon-like peptide-1 receptor agonist lotiglipron (PF-07081532) for type 2 diabetes and obesity: Two randomized, placebo-controlled, multiple-ascending-dose Phase 1 studies.
Diabetes Obes Metab
; 2024 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38751362
2.
Employing zero-inflated beta distribution in an exposure-response analysis of TYK2/JAK1 inhibitor brepocitinib in patients with plaque psoriasis.
J Pharmacokinet Pharmacodyn
; 2024 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38431923
3.
Tolerability, safety and pharmacodynamics of oral, small-molecule glucagon-like peptide-1 receptor agonist danuglipron for type 2 diabetes: A 12-week, randomized, placebo-controlled, Phase 2 study comparing different dose-escalation schemes.
Diabetes Obes Metab
; 25(10): 2805-2814, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37311722
4.
Impact of Phase 1 study design on estimation of QT interval prolongation risk using exposure-response analysis.
J Pharmacokinet Pharmacodyn
; 46(6): 605-616, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-31664592
5.
Physiologically Relevant, Humanized Intestinal Systems to Study Metabolism and Transport of Small Molecule Therapeutics.
Drug Metab Dispos
; 46(11): 1581-1587, 2018 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30126862
6.
Capsaicin-evoked cough responses in asthmatic patients: Evidence for airway neuronal dysfunction.
J Allergy Clin Immunol
; 139(3): 771-779.e10, 2017 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-27444176
7.
Modelling of atorvastatin pharmacokinetics and the identification of the effect of a BCRP polymorphism in the Japanese population.
Pharmacogenet Genomics
; 27(1): 27-38, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27787353
8.
Combining the 'bottom up' and 'top down' approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data.
Br J Clin Pharmacol
; 79(1): 48-55, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24033787
9.
Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach.
Pharm Res
; 32(6): 1864-83, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25446771
10.
Incorporation of stochastic variability in mechanistic population pharmacokinetic models: handling the physiological constraints using normal transformations.
J Pharmacokinet Pharmacodyn
; 42(4): 349-73, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26006250
11.
Reduced physiologically-based pharmacokinetic model of repaglinide: impact of OATP1B1 and CYP2C8 genotype and source of in vitro data on the prediction of drug-drug interaction risk.
Pharm Res
; 31(9): 2367-82, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24623479
12.
Efficacy and Safety of Oral Small Molecule Glucagon-Like Peptide 1 Receptor Agonist Danuglipron for Glycemic Control Among Patients With Type 2 Diabetes: A Randomized Clinical Trial.
JAMA Netw Open
; 6(5): e2314493, 2023 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37213102
13.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PF-06817024 in Healthy Participants, Participants with Chronic Rhinosinusitis with Nasal Polyps, and Participants with Atopic Dermatitis: A Phase 1, Randomized, Double-Blind, Placebo-Controlled Study.
J Clin Pharmacol
; 2023 Sep 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-37772436
14.
Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies.
Sci Rep
; 8(1): 4530, 2018 03 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29540740
15.
Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies.
AAPS J
; 19(5): 1499-1512, 2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28752430
16.
Reduction of a Whole-Body Physiologically Based Pharmacokinetic Model to Stabilise the Bayesian Analysis of Clinical Data.
AAPS J
; 18(1): 196-209, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26538125