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1.
Emerg Infect Dis ; 22(2): 217-23, 2016 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26812579

RESUMO

To determine whether 2 readily available indicators predicted survival among patients with Ebola virus disease in Sierra Leone, we evaluated information for 216 of the 227 patients in Bo District during a 4-month period. The indicators were time from symptom onset to healthcare facility admission and quantitative real-time reverse transcription PCR cycle threshold (Ct), a surrogate for viral load, in first Ebola virus-positive blood sample tested. Of these patients, 151 were alive when detected and had reported healthcare facility admission dates and Ct values available. Time from symptom onset to healthcare facility admission was not associated with survival, but viral load in the first Ebola virus-positive blood sample was inversely associated with survival: 52 (87%) of 60 patients with a Ct of >24 survived and 20 (22%) of 91 with a Ct of <24 survived. Ct values may be useful for clinicians making treatment decisions or managing patient or family expectations.


Assuntos
Ebolavirus , Doença pelo Vírus Ebola/mortalidade , Doença pelo Vírus Ebola/virologia , Adolescente , Adulto , Feminino , Doença pelo Vírus Ebola/epidemiologia , Hospitalização , Humanos , Masculino , Pessoa de Meia-Idade , Mortalidade , Vigilância da População , Prognóstico , Serra Leoa/epidemiologia , Adulto Jovem
2.
MMWR Morb Mortal Wkly Rep ; 64(3): 70-3, 2015 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-25632956

RESUMO

Ebola virus disease (Ebola) was first detected in Sierra Leone in May 2014 and was likely introduced into the eastern part of the country from Guinea. The disease spread westward, eventually affecting Freetown, Sierra Leone's densely populated capital. By December 2014, Sierra Leone had more Ebola cases than Guinea and Liberia, the other two West African countries that have experienced widespread transmission. As the epidemic intensified through the summer and fall, an increasing number of infected persons were not being detected by the county's surveillance system until they had died. Instead of being found early in the disease course and quickly isolated, these persons remained in their communities throughout their illness, likely spreading the disease.


Assuntos
Doença pelo Vírus Ebola/prevenção & controle , Vigilância da População/métodos , Características de Residência , Doença pelo Vírus Ebola/epidemiologia , Humanos , Projetos Piloto , Avaliação de Programas e Projetos de Saúde , Serra Leoa/epidemiologia
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