kV reference dosimetry in Australia and New Zealand: Survey results and trends.

PURPOSE: To assess the number of radiotherapy kilovoltage (kV) units in service, their clinical utilization, and methodology and equipment used for absorbed dose determination across Australia and New Zealand. METHODS: A survey was sent to 61 Australian and New Zealand radiotherapy providers in the second half of 2023. RESULTS: Fifty-seven responses were received, with 43 departments having kV units and providing beam quality data for 185 therapeutic kV beams 20-300 kVp. Percentage depth dose curves were compared between five clinical beams with 100 kVp and 2.13-6.28 mm Aluminum half value layers (HVLs), demonstrating large differences that can occur between beams with the same kVp. Eighteen departments provided clinical utilization data for their kV units, with a total of 4458 treatment courses and their corresponding kVp reported. All departments complied with national and international recommendations with respect to the equipment used for reference dosimetry of kV beams; 77% of ionization chambers used for absorbed dose determination were of Farmer-type, with the remaining 23% being plane parallel soft x-ray chambers. Methods of derivation of air-kerma calibration factors varied, with 73% of respondents using a draft document disseminated by the Australian Primary Standards laboratory, 23% using HVL alone, and 6% using other methods. CONCLUSIONS: The results of this survey provide a snapshot of kilovoltage radiation therapy use and the number of kV units across Australia and New Zealand. This data can be used as a point of reference for future investigations into clinical utilization and reference dosimetry methods across Australia and New Zealand or for comparisons with other countries, facilitating standardization of reference dosimetry practice for kilovoltage units.

Quantification of interplay and gradient effects for lung stereotactic ablative radiotherapy (SABR) treatments.

This study quantified the interplay and gradient effects on GTV dose coverage for 3D CRT, dMLC IMRT, and VMAT SABR treatments for target amplitudes of 5-30 mm using 3DVH v3.1 software incorporating 4D Respiratory MotionSim (4D RMS) module. For clinically relevant motion periods (5 s), the interplay effect was small, with deviations in the minimum dose covering the target volume (D99%) of less than ± 2.5% for target amplitudes up to 30 mm. Increasing the period to 60 s resulted in interplay effects of up to ± 15.0% on target D99% dose coverage. The gradient effect introduced by target motion resulted in deviations of up to ± 3.5% in D99% target dose coverage. VMAT treatments showed the largest deviation in dose metrics, which was attributed to the long delivery times in comparison to dMLC IMRT. Retrospective patient analysis indicated minimal interplay and gradient effects for patients treated with dMLC IMRT at the NCCI.

Small field detector correction factors: effects of the flattening filter for Elekta and Varian linear accelerators.

Flattening filter-free (FFF) beams are becoming the preferred beam type for stereotactic radiosurgery (SRS) and stereotactic ablative radiation therapy (SABR), as they enable an increase in dose rate and a decrease in treatment time. This work assesses the effects of the flattening filter on small field output factors for 6 MV beams generated by both Elekta and Varian linear accelerators, and determines differences between detector response in flattened (FF) and FFF beams. Relative output factors were measured with a range of detectors (diodes, ionization cham-bers, radiochromic film, and microDiamond) and referenced to the relative output factors measured with an air core fiber optic dosimeter (FOD), a scintillation dosimeter developed at Chris O'Brien Lifehouse, Sydney. Small field correction factors were generated for both FF and FFF beams. Diode measured detector response was compared with a recently published mathematical relation to predict diode response corrections in small fields. The effect of flattening filter removal on detector response was quantified using a ratio of relative detector responses in FFF and FF fields for the same field size. The removal of the flattening filter was found to have a small but measurable effect on ionization chamber response with maximum deviations of less than ± 0.9% across all field sizes measured. Solid-state detectors showed an increased dependence on the flattening filter of up to ± 1.6%. Measured diode response was within ± 1.1% of the published mathematical relation for all fields up to 30 mm, independent of linac type and presence or absence of a flattening filter. For 6 MV beams, detector correction factors between FFF and FF beams are interchangeable for a linac between FF and FFF modes, providing that an additional uncertainty of up to ± 1.6% is accepted.

Delivery efficiency and susceptibility to setup uncertainties of flattening filter free lung SBRT: influence of isocentre geometry and treatment modality.

Flattening filter free (FFF) photon beams are frequently used in stereotactic body radiation therapy (SBRT) treatments of lung lesions due to favourable dosimetric characteristics and comparable plan quality to conventional flattened beams. For peripheral targets, the treatment isocentre may remain close to the patient midline to minimise collision risks, which we denote as off-axis geometry (OAG). This study used a cohort of ten patients to investigate the sensitivity of OAG SBRT lung plans to offsets in the isocentre position and compared it to those where the isocentre is placed at the centre of the target volume, i.e. central axis geometry (CAG). Comparisons were made for SBRT treatment plans using 3D conformal radiotherapy (3DCRT) and volumetric modulated arc therapy (VMAT). No statistically significant difference was found between OAG and CAG for SBRT treatments delivered with either 3DCRT or VMAT techniques in terms of plan quality metrics. Planned monitor units for 3DCRT plans were significantly less (p < 0.001) using CAG compared to OAG for this patient cohort, suggesting more efficient treatment delivery. These significant differences in delivery efficiency based on isocentre geometry were not observed in the VMAT plans. The susceptibility of 3DCRT and VMAT plans to systematic setup uncertainties of 1 mm and 2 mm was not significantly influenced by choice of isocentre geometry. OAG and CAG based treatments are equally robust to systematic uncertainties in isocentre positioning.

Over-response of synthetic microDiamond detectors in small radiation fields.

The recently commercialized PTW microDiamond detector (T60019) has been designed for use in small radiation fields. Here we report on the measurement of relative output ratios for small fields using five microDiamond detectors. All of the microDiamond detectors over-responded in fields smaller than 20 mm, by up to 9.3% for a 4 mm field. The over-response was independent of accelerator type and choice of collimation. The over-response was slightly larger than that observed in silicon diodes. Since all five microDiamond detectors showed the same over-response the corrections presented here should be transferable to other examples of the microDiamond detector, provided that the detector meets the manufacturing specifications and the beam characteristics are comparable.

Characterization of small-field stereotactic radiosurgery beams with modern detectors.

To derive accurate beam models for stereotactic radiosurgery (SRS) planning it is necessary to characterize the beam with dosimetric measurements. The aim of this study is to identify the best detectors for each task in the characterization process. Output ratios, beam profiles and percentage depth doses were measured for SRS cone diameters of 5-45 mm. Commercially available and emerging detectors were used: Gafchromic EBT2 film, an air-core fibre optic dosimeter (FOD) (developed at Royal Prince Alfred Hospital, Sydney), an IBA stereotactic field diode, a PTW 60012 electron diode and an IBA cc01 small volume thimble ion chamber. Analysis of the measured data supported by baseline Monte Carlo simulation data, led to the following recommendations: (1) water-equivalent detectors (Gafchromic EBT2 film or FOD) are the preferred choice for SRS dosimetry, (2) ion chambers (including small volume chambers with high-density central electrodes) should be avoided due to volume averaging effects and energy dependence, (3) if diodes are used, corrections must be made to account for their over-response in small fields.