Detalhe da pesquisa
1.
Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition.
J Biol Chem
; 300(1): 105492, 2024 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-38000655
2.
Residence Times for Femtomolar and Picomolar Inhibitors of MTANs.
Biochemistry
; 62(11): 1776-1785, 2023 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37204861
3.
Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors.
Biochemistry
; 62(14): 2182-2201, 2023 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37418678
4.
Expedient synthesis of imino-C-nucleoside fleximers featuring a one-pot procedure to prepare aryl triazoles.
Org Biomol Chem
; 21(30): 6134-6140, 2023 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37462413
5.
Kinetic Characterization and Inhibition of Trypanosoma cruzi Hypoxanthine-Guanine Phosphoribosyltransferases.
Biochemistry
; 61(19): 2088-2105, 2022 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36193631
6.
The design of protozoan phosphoribosyltransferase inhibitors containing non-charged phosphate mimic residues.
Bioorg Med Chem
; 74: 117038, 2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36209571
7.
Aminofutalosine Deaminase in the Menaquinone Pathway of Helicobacter pylori.
Biochemistry
; 60(24): 1933-1946, 2021 06 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34077175
8.
Transition State Analogues Enhanced by Fragment-Based Structural Analysis: Bacterial Methylthioadenosine Nucleosidases.
Biochemistry
; 59(7): 831-835, 2020 02 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32022543
9.
Comparison of disaccharide donors for heparan sulfate synthesis: uronic acids vs. their pyranose equivalents.
Org Biomol Chem
; 18(25): 4728-4733, 2020 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32531013
10.
Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis.
Proc Natl Acad Sci U S A
; 114(29): 7617-7622, 2017 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28679637
11.
Using automated glycan assembly (AGA) for the practical synthesis of heparan sulfate oligosaccharide precursors.
Org Biomol Chem
; 17(7): 1817-1821, 2019 02 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30543331
12.
Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis.
Biochemistry
; 56(38): 5090-5098, 2017 09 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28836767
13.
Continuous Fluorescence Assays for Reactions Involving Adenine.
Anal Chem
; 88(23): 11860-11867, 2016 12 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-27779859
14.
New Antibiotic Candidates against Helicobacter pylori.
J Am Chem Soc
; 137(45): 14275-80, 2015 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26494017
15.
Tight binding enantiomers of pre-clinical drug candidates.
Bioorg Med Chem
; 23(17): 5326-33, 2015 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26260335
16.
Inhibition and structure of Toxoplasma gondii purine nucleoside phosphorylase.
Eukaryot Cell
; 13(5): 572-9, 2014 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-24585883
17.
Composition, sequencing and ion mobility mass spectrometry of heparan sulfate-like octasaccharide isomers differing in glucuronic and iduronic acid content.
Eur J Mass Spectrom (Chichester)
; 21(3): 245-54, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26307704
18.
Single-entity heparan sulfate glycomimetic clusters for therapeutic applications.
Angew Chem Int Ed Engl
; 54(9): 2718-23, 2015 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25640820
19.
Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases.
J Biol Chem
; 288(48): 34746-54, 2013 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-24158442
20.
Isofagomine Inhibits Multiple TcdB Variants and Protects Mice from Clostridioides difficile-Induced Mortality.
ACS Infect Dis
; 10(3): 928-937, 2024 03 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38334357