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Background and Objective: Infectious diseases continue to be a global burden and their impact is even worse if the patients already have other comorbidities. Because chronic kidney disease is very frequent, affecting 10% of the population, our study aims to explore the impact that infectious events have on its progression. Material and Methods: This is a retrospective, observational study based on a cohort of 238 dialyzed patients from the Nephrology Clinic of "Dr. Carol Davila" Clinical Hospital of Nephrology, Bucharest, who were followed from their first visit for five years, between 1 January 2007 and 1 January 2022. For each of them, the presence of an infectious event and the moment of the initiation of dialysis were recorded. Results: Statistical analysis showed that the patients who had at least one infectious episode were older (p = 0.004), their hemoglobin and lymphocytes were significantly lower (p = 0.03 and p = 0.02, respectively) and the time until the initiation of dialysis was lower (p = 0.007). Also, the preservation of kidney function was influenced by the number and the severity of infectious episodes. In the univariate Cox model, the following variables were associated with increased risk of dialysis: advanced age (p: 0.009; HR: 1.021; CI: 1.005 to 1.036), low hemoglobin (p: 0.001; HR: 0.861; CI: 0.786 to 0.943), previous diagnosis of chronic obstructive pulmonary disease (p: 0.002; HR: 2.467; CI: 1.376 to 4.424), presence of hematuria (p: 0.03; HR: 1.604; CI: 1.047 to 2.457) and increased values of proteinuria (p: 0.01; HR: 1.122; CI: 1.028 to 1.224) and of serum creatinine measured both at the time of the first visit and at the time of each infectious event (p: <0.001; HR: 1.262; CI: 1.141 to 1.396). Also, the presence of an infectious episode was associated with a 1.7-fold increase in the risk of dialysis initiation. The independent predictors of survival identified by the multivariate Cox model were age (p: 0.004; HR: 1.034; CI: 1.010-1.058), serum creatinine (p: <0.001; HR: 1.421; CI: 1.203 to 1.658) and proteinuria (p: <0.001; HR: 1.241; CI: 1.126 to 1.369) at the time of enrollment, but also the presence of an infectious episode during the patient's evolution (p: 0.04; HR: 1.705; CI: 1.013 to 2.868). Conclusions: In the evolution of patients with chronic kidney disease, an active search for individual factors favoring the occurrence of infectious episodes should be taken into consideration to prevent a faster progression toward end-stage kidney disease.
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Diálise Renal , Insuficiência Renal Crônica , Humanos , Creatinina , Progressão da Doença , Insuficiência Renal Crônica/complicações , Insuficiência Renal Crônica/epidemiologia , Estudos Retrospectivos , Proteinúria/complicações , Hemoglobinas , Fatores de RiscoRESUMO
Four-dimensional computerized tomography (4DCT) is required for stereotactic ablative body radiotherapy (SABR) of mobile targets to account for tumor motion during treatment planning and delivery. In this study, we report on the impact of an image review quality assurance process performed prior to treatment planning by medical physicists for 4DCT scans used for SABR treatment. Reviews were performed of 211 4DCT scans (193 patients) over a 3-yr period (October 2014 to October 2017). Treatment sites included lung (n = 168), kidney/adrenal/adrenal gland (n = 12), rib (n = 4), mediastinum (n = 10), liver (n = 2), T-spine (n = 1), and other abdominal sites (n = 14). It was found that in 23% (n = 49) of cases patient management was altered due to the review process. The most frequent intervention involved patient-specific contouring advice (n = 35 cases, 17%) including adjustment of internal target volume (ITV) margins. In 13 cases (6%) a rescan was requested due to extensive motion artifact rendering the scan inadequate for SABR treatment planning. 4DCT review by medical physicists was found to be an effective method to improve plan quality for SABR.
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Tomografia Computadorizada Quadridimensional/métodos , Processamento de Imagem Assistida por Computador/métodos , Neoplasias/cirurgia , Órgãos em Risco/efeitos da radiação , Radiocirurgia/métodos , Planejamento da Radioterapia Assistida por Computador/métodos , Humanos , Estudos Prospectivos , Dosagem Radioterapêutica , Radioterapia de Intensidade Modulada/métodos , Respiração , Estudos RetrospectivosRESUMO
The evolution from conventional to modern agricultural practices, characterized by Agriculture 4.0 principles such as the application of innovative materials, smart water, and nutrition management, addresses the present-day challenges of food supply. In this context, polymer hydrogels have become a promising material for enhancing agricultural productivity due to their ability to retain and then release water, which can help alleviate the need for frequent irrigation in dryland environments. Furthermore, the controlled release of fertilizers by the hydrogels decreases chemical overdosing risks and the environmental impact associated with the use of agrochemicals. The potential of polymer hydrogels in sustainable agriculture and farming and their impact on soil quality is revealed by their ability to deliver nutritional and protective active ingredients. Thus, the impact of hydrogels on plant growth, development, and yield was discussed. The question of which hydrogels are more suitable for agriculture-natural or synthetic-is debatable, as both have their merits and drawbacks. An analysis of polymer hydrogel life cycles in terms of their initial material has shown the advantage of bio-based hydrogels, such as cellulose, lignin, starch, alginate, chitosan, and their derivatives and hybrids, aligning with sustainable practices and reducing dependence on non-renewable resources.
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Bolus is commonly used to improve dose distributions in radiotherapy in particular if dose to skin must be optimised such as in breast or head and neck cancer. We are documenting four years of experience with 3D printed bolus at a large cancer centre. In addition to this we review the quality assurance (QA) program developed to support it. More than 2000 boluses were produced between Nov 2018 and Feb 2023 using fused deposition modelling (FDM) printing with polylactic acid (PLA) on up to five Raise 3D printers. Bolus is designed in the radiotherapy treatment planning system (Varian Eclipse), exported to an STL file followed by pre-processing. After checking each bolus with CT scanning initially we now produce standard quality control (QC) wedges every month and whenever a major change in printing processes occurs. A database records every bolus printed and manufacturing details. It takes about 3 days from designing the bolus in the planning system to delivering it to treatment. A 'premium' PLA material (Spidermaker) was found to be best in terms of homogeneity and CT number consistency (80 HU +/- 8HU). Most boluses were produced for photon beams (93.6%) with the rest used for electrons. We process about 120 kg of PLA per year with a typical bolus weighing less than 500 g and the majority of boluses 5 mm thick. Print times are proportional to bolus weight with about 24 h required for 500 g material deposited. 3D printing using FDM produces smooth and reproducible boluses. Quality control is essential but can be streamlined.
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Impressão Tridimensional , Humanos , Garantia da Qualidade dos Cuidados de Saúde/normas , Controle de Qualidade , Planejamento da Radioterapia Assistida por Computador , Tomografia Computadorizada por Raios X , Dosagem Radioterapêutica , Poliésteres/químicaRESUMO
Biomaterials are an important and integrated part of modern medicine, and their development and improvement are essential. The fundamental requirement of a biomaterial is found to be in its interaction with the surrounding environment, with which it must coexist. The aim of this study was to assess the biological characteristics of hydroxyapatite (HAp)-based coatings doped with Mg and Zn ions obtained by the pulsed galvanostatic electrochemical method on the surface of pure titanium (cp-Ti) functionalized with titanium dioxide nanotubes (NTs TiO2) obtained by anodic oxidation. The obtained results highlighted that the addition of Zn or Mg into the HAp structure enhances the in vitro response of the cp-Ti surface functionalized with NT TiO2. The contact angle and surface free energy showed that all the developed surfaces have a hydrophilic character in comparison with the cp-Ti surface. The HAp-based coatings doped with Zn registered superior values than the ones with Mg, in terms of biomineralization, electrochemical behavior, and cell interaction. Overall, it can be said that the addition of Mg or Zn can enhance the in vitro behavior of the HAp-based coatings in accordance with clinical requirements. Antibacterial tests showed that the proposed HAp-Mg coatings had no efficiency against Escherichia coli, while the HAp-Zn coatings registered the highest antibacterial efficiency.
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The incorporation of the metal phase into cellulose hydrogels, resulting in the formation of metallogels, greatly expands their application potential by introducing new functionalities and improving their performance in various fields. The unique antiviral, antibacterial, antifungal, and anticancer properties of metal and metal oxide nanoparticles (Ag, Au, Cu, CuxOy, ZnO, Al2O3, TiO2, etc.), coupled with the biocompatibility of cellulose, allow the development of composite hydrogels with multifunctional therapeutic potential. These materials can serve as efficient carriers for controlled drug delivery, targeting specific cells or pathogens, as well as for the design of artificial tissues or wound and burn dressings. Cellulose-based metallogels can be used in the food packaging industry to provide biodegradable and biocidal materials to extend the shelf life of the goods. Metal and bimetallic nanoparticles (Au, Cu, Ni, AuAg, and AuPt) can catalyze chemical reactions, enabling composite cellulose hydrogels to be used as efficient catalysts in organic synthesis. In addition, metal-loaded hydrogels (with ZnO, TiO2, Ag, and Fe3O4 nanoparticles) can exhibit enhanced adsorption capacities for pollutants, such as dyes, heavy metal ions, and pharmaceuticals, making them valuable materials for water purification and environmental remediation. Magnetic properties imparted to metallogels by iron oxides (Fe2O3 and Fe3O4) simplify the wastewater treatment process, making it more cost-effective and environmentally friendly. The conductivity of metallogels due to Ag, TiO2, ZnO, and Al2O3 is useful for the design of various sensors. The integration of metal nanoparticles also allows the development of responsive materials, where changes in metal properties can be exploited for stimuli-responsive applications, such as controlled release systems. Overall, the introduction of metal phases augments the functionality of cellulose hydrogels, expanding their versatility for diverse applications across a broad spectrum of industries not envisaged during the initial research stages.
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Metallogels represent a class of composite materials in which a metal can be a part of the gel network as a coordinated ion, act as a cross-linker, or be incorporated as metal nanoparticles in the gel matrix. Cellulose is a natural polymer that has a set of beneficial ecological, economic, and other properties that make it sustainable: wide availability, renewability of raw materials, low-cost, biocompatibility, and biodegradability. That is why metallogels based on cellulose hydrogels and additionally enriched with new properties delivered by metals offer exciting opportunities for advanced biomaterials. Cellulosic metallogels can be either transparent or opaque, which is determined by the nature of the raw materials for the hydrogel and the metal content in the metallogel. They also exhibit a variety of colors depending on the type of metal or its compounds. Due to the introduction of metals, the mechanical strength, thermal stability, and swelling ability of cellulosic materials are improved; however, in certain conditions, metal nanoparticles can deteriorate these characteristics. The embedding of metal into the hydrogel generally does not alter the supramolecular structure of the cellulose matrix, but the crystallinity index changes after decoration with metal particles. Metallogels containing silver (0), gold (0), and Zn(II) reveal antimicrobial and antiviral properties; in some cases, promotion of cell activity and proliferation are reported. The pore system of cellulose-based metallogels allows for a prolonged biocidal effect. Thus, the incorporation of metals into cellulose-based gels introduces unique properties and functionalities of this material.
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Metallogels are a class of materials produced by the complexation of polymer gels with metal ions that can form coordination bonds with the functional groups of the gel. Hydrogels with metal phases attract special attention due to the numerous possibilities for functionalization. Cellulose is preferable for the production of hydrogels from economic, ecological, physical, chemical, and biological points of view since it is inexpensive, renewable, versatile, non-toxic, reveals high mechanical and thermal stability, has a porous structure, an imposing number of reactive OH groups, and good biocompatibility. Due to the poor solubility of natural cellulose, the hydrogels are commonly produced from cellulose derivatives that require multiple chemical manipulations. However, there is a number of techniques of hydrogel preparation via dissolution and regeneration of non-derivatized cellulose of various origins. Thus, hydrogels can be produced from plant-derived cellulose, lignocellulose and cellulose wastes, including agricultural, food and paper wastes. The advantages and limitations of using solvents are discussed in this review with regard to the possibility of industrial scaling up. Metallogels are often formed on the basis of ready-made hydrogels, which is why the choice of an adequate solvent is important for obtaining desirable results. The methods of the preparation of cellulose metallogels with d-transition metals in the present state of the art are reviewed.
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Bibliometric analysis is an effective method used to identify research trends based on historical publications that involves combining different frameworks, tools and methods, leading to the creation of different metrics. This study employed bibliometric analysis to investigate the global health risk assessment of heavy metals in food from 2000 to 2022 using Web of Science and VOSviewer. We explore publication trends, affiliations, countries, journals, citations, keywords and author collaborations. Of the 573 publications on this topic, there has been a notable increase in recent years. The Ministry of Agriculture and Rural Affairs (China) and Shahid Beheshti University of Medical Sciences (Iran) are the most prolific affiliations. Environmental Science and Pollution Research is the top journal. Notably, "heavy metals", "risk assessment", "cadmium", "lead", and "trace elements" are frequently used keywords. A study by Miraglia et al. in 2009 received the most citations. Amin Mousavi Khaneghah (Poland) is the most prolific author, with 24 papers. Articles mainly focus on contamination levels in fish, seafood, cereals, dairy, meat, and fruit/vegetables. Some studies highlight potential risks, necessitating stricter food product controls for consumer safety.
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INTRODUCTION: Total body irradiation (TBI) practices vary considerably amongst centres, and the risk of treatment related toxicities remains unclear. We report lung doses for 142 TBI patients who underwent either standing TBI with lung shield blocks or lying TBI without blocks. METHODS: Lung doses were calculated for 142 TBI patients treated between June 2016 and June 2021. Patients were planned using Eclipse (Varian Medical Systems) using AAA_15.6.06 for photon dose calculations and EMC_15.6.06 for electron chest wall boost fields. Mean and maximum lung doses were calculated. RESULTS: Thirty-seven patients (26.2%) were treated standing using lung shielding blocks with 104 (73.8%) treated lying down. Lowest relative mean lung doses were achieved using lung shielding blocks in standing TBI, reducing the mean lung doses to 75.2% of prescription (9.9 Gy), ±4.1% (range 68.6-84.1%) for a prescribed dose of 13.2 Gy in 11 fractions, including contributions from electron chest wall boost fields, compared to 12 Gy in 6 fraction lying TBI receiving 101.6% mean lung dose (12.2 Gy) ±2.4% (range 95.2-109.5%) (P ⪠0.05). Patients treated lying down with 2 Gy single fraction received the highest relative mean lung dose on average, with 108.4% (2.2 Gy) ±2.6% of prescription (range 103.2-114.4%). CONCLUSION: Lung doses have been reported for 142 TBI patients using the lying and standing techniques described herein. Lung shielding blocks significantly reduced mean lung doses despite the addition of electron boost fields to the chest wall.
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Neoplasias Hematológicas , Irradiação Corporal Total , Humanos , Irradiação Corporal Total/efeitos adversos , Irradiação Corporal Total/métodos , Pulmão , Neoplasias Hematológicas/etiologia , Neoplasias Hematológicas/terapia , Dosagem RadioterapêuticaRESUMO
Background and purpose: Reduction of respiratory tumour motion is important in liver stereotactic body radiation therapy (SBRT) to reduce side effects and improve tumour control probability. We have assessed the distribution of use of voluntary exhale breath hold (EBH), abdominal compression (AC), free breathing gating (gating) and free breathing (FB), and the impact of these on treatment time. Materials and Methods: We assessed all patients treated in a single institution with liver SBRT between September 2017 and September 2021. Data from pre-simulation motion management assessment using fluoroscopic assessment of liver dome position in repeat breath holds, and motion with and without AC, was reviewed to determine liver dome position consistency in EBH and the impact of AC on motion. Treatment time was assessed for all fractions as time from first image acquisition to last treatment beam off. Results: Of 136 patients treated with 145 courses of liver SBRT, 68 % were treated in EBH, 20 % with AC, 7 % in gating and 5 % in FB. AC resulted in motion reduction < 1 mm in 9/26 patients assessed. Median treatment time was higher using EBH (39 min) or gating (42 min) compared with AC (30 min) or FB (24 min) treatments. Conclusions: Motion management in liver SBRT needs to be assessed per-patient to ensure appropriate techniques are applied. Motion management significantly impacts treatment time therefore patient comfort must also be taken into account when selecting the technique for each patient.
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In the present work, the possibility of increasing the calcium carbonate (CaCO3) content in sheets of paper to optimize their properties was investigated. A new class of polymeric additives for papermaking is proposed as well as a method for their use in paper sheet containing the CaCO3 precipitated addition. Calcium carbonate precipitated (PCC) and fibers cellulose were adjusted with a cationic polyacrylamide flocculating agent (polydiallyldimethylammonium chloride (plyDADMAC) or cationic polyacrylamide (cPAM)). PCC was obtained in the laboratory by a double-exchange reaction between calcium chloride (CaCl2) and sodium carbonate (Na2CO3) suspension. After testing, the dosage of PCC was established at 35%. To improve the systems of additives studied, the materials obtained were characterized and their optical and mechanical properties were analysed. The PCC had a positive influence over all of the paper samples, but in the case of use of cPAM and polyDADMAC polymers the paper obtained had superior properties compared to the paper obtained without additives. Also, the samples obtained in the presence of cationic polyacrylamide exhibit superior properties to those obtained in the presence of polyDADMAC.
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Foodborne pathogens represent one of the most dangerous threats to public health along the food chain all over the world. Over time, many methods were studied for pathogen inhibition in food, such as the development of novel packaging materials with enhanced properties for microorganisms' growth inhibition (coatings, films) and the use of emerging technologies, like ultrasound, radio frequency or microwave. The aim of this study was to evaluate the current trends in the food industry for pathogenic microorganisms' inhibition and food preservation in two directions, namely technology used for food processing and novel packaging materials development. Five technologies were discussed in this study, namely high-voltage atmospheric cold plasma (HVACP), High-Pressure Processing (HPP), microwaves, radio frequency (RF) heating and ultrasound. These technologies proved to be efficient in the reduction of pathogenic microbial loads in different food products. Further, a series of studies were performed, related to novel packaging material development, by using a series of antimicrobial agents such as natural extracts, bacteriocins or antimicrobial nanoparticles. These materials proved to be efficient in the inhibition of a wide range of microorganisms, including Gram-negative and Gram-positive bacteria, fungi and yeasts.
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Osseointegration plays the most important role in the success of an implant. One of the applications of hydroxyapatite (HAp) is as a coating for metallic implants due to its bioactive nature, which improves osteoconduction. The purpose of this research was to assess the in vitro behavior of HAp undoped and doped with Ag and/or Sr obtained by galvanostatic pulsed electrochemical deposition. The coatings were investigated in terms of chemical bonds, contact angle and surface free energy, electrochemical behavior, in vitro biomineralization in acellular media (SBF and PBS), and biocompatibility with preosteoblasts cells (MC3T3-E1 cell line). The obtained results highlighted the beneficial impact of Ag and/or Sr on the HAp. The FTIR spectra confirmed the presence of hydroxyapatite within all coatings, while in terms of wettability, the contact angle and surface free energy investigations showed that all surfaces were hydrophilic. The in vitro behavior of MC3T3-E1 indicated that the presence of Sr in the HAp coatings as a unique doping agent or in combination with Ag elicited improved cytocompatibility in terms of cell proliferation and osteogenic differentiation. Therefore, the composite HAp-based coatings showed promising potential for bone regeneration applications.
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Titanium and its based alloys are frequently selected for designing biomedical implants and it is thus necessary to study as detailed as possible their corrosion behavior in biological solutions, such as those in the human body environment. In this paper, with the use of molecular orbital calculation, we designed and developed alloys in the Ti-19Mo-xW system (x = 7, 8, 9, and 10 wt%) and investigated the influence of different contents of tungsten on the behavior of Ti-19Mo-xW alloy samples following corrosion in simulated body fluid (SBF). The values of Bo¯ (bond order) and Md¯ (the metal-orbital energy level) were calculated for each alloy and correlations were established between Bo¯ and the content of tungsten. It was found that with the increase in tungsten content, the value of Bo¯ increases. Regarding the values of the corrosion resistance in SBF that resulted from the investigated alloys, the Ti19Mo7W alloy is distinguished by the lowest value of the corrosion current density and the lowest corrosion rate.
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In this paper, the synthesis and characterization of two polycaprolactone-polydimethylsiloxane (PDMS-CL) copolymers with biodegradable properties are reported. A comparative study was carried out using an aminopropyl-terminated polydimethylsiloxane macro-initiator (APDMS) with two different molecular weights. The copolymers (PDMS-CL-1 and PDMS-CL-2) were obtained by ring-opening polymerization of É-caprolactone using APDMS as initiators and stannous 2-ethylhexanoate as a catalyst. The copolymer's structures were confirmed by Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (1H-NMR) spectra, and energy dispersion spectroscopy (EDX). Surface morphology was investigated using scanning electron microscopy (SEM) and atomic force microscopy (AFM). The hydrophobic properties of the copolymers were demonstrated by the water contact angle and water vapor sorption capacity. Additionally, biological tests were conducted on San Marzano type tomato plants (Lypercosium esculentum) to assess the synthesized copolymers' susceptibility to the environment in terms of biological stability and metabolic activity. The biodegradation of PDMS-CL-1 and PDMS-CL-2 copolymers does not have a dangerous effect on the metabolic activity of plants, which makes it a convenient product in interaction with the environment.
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Given the predominantly negative impact of heavy metals on living organisms, the present study proposed to evaluate the adsorption performances under static conditions of Cd (II) from aqueous solutions on unmodified Sarkanda grass lignin compared to the adsorption performances of polysaccharide polymers chemically functionalized, obtained by synthesis and in their native state, but which, although effective, have a cost price that does not allow for large-scale expansion. To improve the retention of Cd (II) on this aromatic component of the biomass resulting from the processing of lignocellulosic materials, different experimental conditions (pH, concentration, dose and contact time) were followed. The Freundlich and Langmuir isotherms were used to describe the equilibrium conditions. Adsorption kinetics were assessed using the Lagergren I and Ho and McKay II kinetic models, furnishing informative insights into the process mechanism. Lignin adsorption capacity was also analyzed by performing biological tests on tomato seeds (Lypercosium esculentum), since heavy metals are known to be a stress factor for seeds by disturbing the osmotic equilibrium. Through the prism of the investigated parameters and under precisely established experimental conditions, unmodified Sarkanda grass lignin-an aromatic biopolymer-can be recommended as a promising adsorbent for the retention of Cd (II) from aqueous solutions, successfully replacing polysaccharide, especially cellulose-based polymers.
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One major problem with the overuse of antibiotics is that the microorganisms acquire resistance; thus the dose must be increased unsustainably. To overcome this problem, researchers from around the world are actively investigating new types of antimicrobials. Zinc oxide (ZnO) nanoparticles (NPs) have been proven to exhibit strong antimicrobial effects; moreover, the Food and Drugs Administration (FDA) considers ZnO as GRAS (generally recognized as safe). Many essential oils have antimicrobial activity and their components do not generate resistance over time. One of the drawbacks is the high volatility of some components, which diminishes the antimicrobial action as they are eliminated. The combination of ZnO NPs and essential oils can synergistically produce a stronger antimicrobial effect, and some of the volatile compounds can be retained on the nanoparticles' surface, ensuring a better-lasting antimicrobial effect. The samples were characterized with X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-Vis), and thermal analysis (TG-DSC) coupled with analysis of evolved gases using FTIR. The ZnO NPs, with a size of ~35 nm, exhibited a loading between 1.44% and 15.62%-the lower values were specific for limonene-containing oils (e.g., orange, grapefruit, bergamot, or limette), while high values were obtained from cinnamon, minzol, thyme, citronella, and lavender oils-highlighting differences among non-polar terpenes and alcohol or aldehyde derivatives. The antibacterial assay indicated the existence of a synergic action among components and a high dependency on the percentage of loaded oil. Loaded nanoparticles offer immense potential for the development of materials with specific applications, such as wound dressings or food packaging. These nanoparticles can be utilized in scenarios where burst delivery is desired or when prolonged antibacterial activity is sought.
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Polymers are of great interest in areas such as agriculture, medicine and pharmacy, the food and cosmetic industries, and the chemical and construction industries. However, many polymers are nonbiodegradable and are not environmentally friendly. They are highly resistant to degradation and therefore can lead to waste disposal problems. In recent years, the interest in the microbial degradation of polymeric materials has grown due to the desire for less waste pollution in the environment. In this study, the biodegradable polymer that was obtained by the ring-opening polymerization of ε-caprolactone (CL) using an aminopropyl-polydimethylsiloxane (APDMS) oligomer and the effects of the polymer towards the growth and development of tomato plants (Lypercosium esculentum) were investigated. The obtained product was characterized using FTIR spectroscopy, NMR spectroscopy, and energy dispersion spectroscopy (EDX) analysis, and the effects of this compound on the evolution of tomato plants (Lypercosium esculentum) were studied. We also studied the biological stability of the product by identifying some of the microorganisms that developed on the surface, given its susceptibility to biodegradation.
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The presence of potentially toxic elements in drinking water can be dangerous for human health because of their bioaccumulation and toxicity, which is a huge concern for many researchers. In the case of bottled water, the exposure to toxic elements is achieved, especially by ingestion, leading to disorders of important functions of the human body. The aim of this study was the detection of some potentially toxic elements, from 50 samples of bottled drinking water, available on the Romanian market. Based on obtained concentrations, an assessment of the carcinogenic and non-carcinogenic health risk was performed. The concentrations of potentially toxic elements analyzed were below the maximum allowable limits, for all contaminants, excluding Pb and Fe. Moreover, the results of total risk via ingestion, showed that 30% of samples had an Hazard Quotient (HQ) < 1, and 70% had an HQ > 1; which implies a potential risk following the consumption of those samples. Concerning total cancer risk, 28% of the samples are in the acceptable level, while 72% of the samples are considered harmful and can lead to a type of cancer after repeated exposure. The study concluded that long term use of bottled water of poor quality may pose a hazard to human health; it is helpful for inhabitants to avoid ingestion of contaminated water.