Detalhe da pesquisa
1.
Selective deuteration of bupropion slows epimerization and reduces metabolism.
Bioorg Med Chem Lett
; 76: 129009, 2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36174836
2.
Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development.
J Pharmacol Exp Ther
; 362(2): 359-367, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28611092
3.
Cytochrome P450 3A4 and CYP3A5-Catalyzed Bioactivation of Lapatinib.
Drug Metab Dispos
; 44(10): 1584-97, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27450182
4.
Altering metabolic profiles of drugs by precision deuteration: reducing mechanism-based inhibition of CYP2D6 by paroxetine.
J Pharmacol Exp Ther
; 354(1): 43-54, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25943764
5.
In vitro metabolism of oxymetazoline: evidence for bioactivation to a reactive metabolite.
Drug Metab Dispos
; 39(4): 693-702, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21177487
6.
Design, synthesis, and progress toward optimization of potent small molecule antagonists of CC chemokine receptor 8 (CCR8).
J Med Chem
; 49(9): 2669-72, 2006 May 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-16640325
7.
Dual Therapeutic Effects of C-10068, a Dextromethorphan Derivative, Against Post-Traumatic Nonconvulsive Seizures and Neuroinflammation in a Rat Model of Penetrating Ballistic-Like Brain Injury.
J Neurotrauma
; 32(20): 1621-32, 2015 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25794265
8.
Identification and characterization of oxymetazoline glucuronidation in human liver microsomes: evidence for the involvement of UGT1A9.
J Pharm Sci
; 100(2): 784-93, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20669329
9.
Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.
J Med Chem
; 54(13): 4752-72, 2011 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21650221
10.
Comparison of intrinsic clearance in liver microsomes and hepatocytes from rats and humans: evaluation of free fraction and uptake in hepatocytes.
Drug Metab Dispos
; 34(9): 1600-5, 2006 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-16790553
11.
Investigation of drug-drug interaction potential of bortezomib in vivo in female Sprague-Dawley rats and in vitro in human liver microsomes.
Drug Metab Dispos
; 34(4): 702-8, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16443666
12.
Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib.
Drug Metab Dispos
; 33(11): 1723-8, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-16103134