Detalhe da pesquisa
1.
Discovery and biocatalytic characterization of opine dehydrogenases by metagenome mining.
Appl Microbiol Biotechnol
; 108(1): 101, 2024 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-38229296
2.
Gluing GAP to RAS Mutants: A New Approach to an Old Problem in Cancer Drug Development.
Int J Mol Sci
; 25(5)2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38473821
3.
Mechanism-Based Redesign of GAP to Activate Oncogenic Ras.
J Am Chem Soc
; 145(37): 20302-20310, 2023 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-37682266
4.
Opine dehydrogenases, an underexplored enzyme family for the enzymatic synthesis of chiral amines.
Biotechnol Bioeng
; 120(10): 2793-2808, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37334502
5.
Immobilization of the Aspartate Ammonia-Lyase from Pseudomonas fluorescens R124 on Magnetic Nanoparticles: Characterization and Kinetics.
Chembiochem
; 23(7): e202100708, 2022 04 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35114050
6.
Primary Founder Mutations in the PRKDC Gene Increase Tumor Mutation Load in Colorectal Cancer.
Int J Mol Sci
; 23(2)2022 Jan 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35054819
7.
Structure-based inhibitor design of mutant RAS proteins-a paradigm shift.
Cancer Metastasis Rev
; 39(4): 1091-1105, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32715349
8.
Assessment of Tractable Cysteines for Covalent Targeting by Screening Covalent Fragments.
Chembiochem
; 22(4): 743-753, 2021 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33030752
9.
Detection of Genomic Uracil Patterns.
Int J Mol Sci
; 22(8)2021 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33918885
10.
What's in a name? From "fluctuation fit" to "conformational selection": rediscovery of a concept.
Hist Philos Life Sci
; 43(3): 88, 2021 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34244885
11.
Structural insights into the tyrosine phosphorylation-mediated inhibition of SH3 domain-ligand interactions.
J Biol Chem
; 294(12): 4608-4620, 2019 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-30659095
12.
p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells.
Nucleic Acids Res
; 45(19): 11056-11069, 2017 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-28977491
13.
The Fourth Wave of Biocatalysis Emerges- The 13 th International Symposium on Biocatalysis and Biotransformations.
Chembiochem
; 19(4): 284-287, 2018 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29337411
14.
Detection of uracil within DNA using a sensitive labeling method for in vitro and cellular applications.
Nucleic Acids Res
; 44(3): e28, 2016 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-26429970
15.
A Hidden Active Site in the Potential Drug Target Mycobacterium tuberculosis dUTPase Is Accessible through Small Amplitude Protein Conformational Changes.
J Biol Chem
; 291(51): 26320-26331, 2016 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-27815500
16.
Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.
Br J Cancer
; 117(1): 113-123, 2017 Jun 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28535155
17.
The novel technique of vapor pressure analysis to monitor the enzymatic degradation of PHB by HPLC chromatography.
Anal Biochem
; 521: 20-27, 2017 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28069452
18.
A Methylidene Group in the Phosphonic Acid Analogue of Phenylalanine Reverses the Enantiopreference of Binding to Phenylalanine Ammonia-Lyases.
Adv Synth Catal
; 359(12): 2109-2120, 2017 06 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-28919846
19.
Perturbation of genome integrity to fight pathogenic microorganisms.
Biochim Biophys Acta Gen Subj
; 1861(1 Pt B): 3593-3612, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27217086
20.
The First Enantioselective Total Synthesis of (-)-trans-Dihydronarciclasine.
J Nat Prod
; 80(6): 1909-1917, 2017 06 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28581297