Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial.

Butler, Christopher C; Hobbs, F D Richard; Gbinigie, Oghenekome A; Rahman, Najib M; Hayward, Gail; Richards, Duncan B; Dorward, Jienchi; Lowe, David M; Standing, Joseph F; Breuer, Judith; Khoo, Saye; Petrou, Stavros; Hood, Kerenza; Nguyen-Van-Tam, Jonathan S; Patel, Mahendra G; Saville, Benjamin R; Marion, Joe; Ogburn, Emma; Allen, Julie; Rutter, Heather; Francis, Nick; Thomas, Nicholas P B; Evans, Philip; Dobson, Melissa; Madden, Tracie-Ann; Holmes, Jane; Harris, Victoria; Png, May Ee; Lown, Mark; van Hecke, Oliver; Detry, Michelle A; Saunders, Christina T; Fitzgerald, Mark; Berry, Nicholas S; Mwandigha, Lazaro; Galal, Ushma; Mort, Sam; Jani, Bhautesh D; Hart, Nigel D; Ahmed, Haroon; Butler, Daniel; McKenna, Micheal; Chalk, Jem; Lavallee, Layla; Hadley, Elizabeth; Cureton, Lucy; Benysek, Magdalena; Andersson, Monique; Coates, Maria; Barrett, Sarah.

Lancet ; 401(10373): 281-293, 2023 01 28.

Artigo em Inglês | MEDLINE | ID: mdl-36566761

2.

Inhaled Budesonide for COVID-19 in People at Higher Risk of Complications in the Community: The UK National Community Randomi.

Hobbs, Richard; Gbinigie, Oghenekome; Ogburn, Emma; Yu, Ly-Mee; van Hecke, Oliver; Dorward, Jienchi; Butler, Chris; Saville, Benjamin.

Ann Fam Med ; (21 Suppl 1)2023 01 01.

Artigo em Inglês | MEDLINE | ID: mdl-36944089

3.

Inhaled budesonide for COVID-19 in people at high risk of complications in the community in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial.

Yu, Ly-Mee; Bafadhel, Mona; Dorward, Jienchi; Hayward, Gail; Saville, Benjamin R; Gbinigie, Oghenekome; Van Hecke, Oliver; Ogburn, Emma; Evans, Philip H; Thomas, Nicholas P B; Patel, Mahendra G; Richards, Duncan; Berry, Nicholas; Detry, Michelle A; Saunders, Christina; Fitzgerald, Mark; Harris, Victoria; Shanyinde, Milensu; de Lusignan, Simon; Andersson, Monique I; Barnes, Peter J; Russell, Richard E K; Nicolau, Dan V; Ramakrishnan, Sanjay; Hobbs, F D Richard; Butler, Christopher C.

Lancet ; 398(10303): 843-855, 2021 09 04.

Artigo em Inglês | MEDLINE | ID: mdl-34388395

4.

Primary care preparedness for the SARS-CoV-2 pandemic: a survey of NHS GPs.

Pilbeam, Caitlin; Edwards, George; Tonkin-Crine, Sarah; Raymond, Meriel; Van Hecke, Oliver; Gobat, Nina.

Fam Pract ; 39(3): 332-339, 2022 05 28.

Artigo em Inglês | MEDLINE | ID: mdl-34871397

5.

Parents' perceptions of antibiotic use and antibiotic resistance (PAUSE): a qualitative interview study.

Van Hecke, Oliver; Butler, Chris C; Wang, Kay; Tonkin-Crine, Sarah.

J Antimicrob Chemother ; 74(6): 1741-1747, 2019 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-30879040

6.

Medications that reduce emergency hospital admissions: an overview of systematic reviews and prioritisation of treatments.

Bobrovitz, Niklas; Heneghan, Carl; Onakpoya, Igho; Fletcher, Benjamin; Collins, Dylan; Tompson, Alice; Lee, Joseph; Nunan, David; Fisher, Rebecca; Scott, Brittney; O'Sullivan, Jack; Van Hecke, Oliver; Nicholson, Brian D; Stevens, Sarah; Roberts, Nia; Mahtani, Kamal R.

BMC Med ; 16(1): 115, 2018 Jul 26.

Artigo em Inglês | MEDLINE | ID: mdl-30045724

7.

Implications of Antibiotic Resistance for Patients' Recovery From Common Infections in the Community: A Systematic Review and Meta-analysis.

van Hecke, Oliver; Wang, Kay; Lee, Joseph J; Roberts, Nia W; Butler, Chris C.

Clin Infect Dis ; 65(3): 371-382, 2017 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-28369247

8.

Clinician-targeted interventions to influence antibiotic prescribing behaviour for acute respiratory infections in primary care: an overview of systematic reviews.

Tonkin-Crine, Sarah Kg; Tan, Pui San; van Hecke, Oliver; Wang, Kay; Roberts, Nia W; McCullough, Amanda; Hansen, Malene Plejdrup; Butler, Christopher C; Del Mar, Chris B.

Cochrane Database Syst Rev ; 9: CD012252, 2017 09 07.

Artigo em Inglês | MEDLINE | ID: mdl-28881002

9.

Chaperones for intimate examinations in family medicine: findings from a pilot study in Melbourne, Australia.

Jones, Kay; Biezen, Ruby; Beovich, Bronwyn; van Hecke, Oliver.

Med Sci Law ; 55(1): 6-10, 2015 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-24477199

10.

Cost-utility analysis of molnupiravir plus usual care versus usual care alone as early treatment for community-based adults with COVID-19 and increased risk of adverse outcomes in the UK PANORAMIC trial.

Png, May Ee; Harris, Victoria; Grabey, Jenna; Hart, Nigel David; Jani, Bhautesh Dinesh; Butler, Daniel; Carson-Stevens, Andrew; Coates, Maria; Cureton, Lucy; Dobson, Melissa; Dorward, Jienchi; Evans, Philip; Francis, Nick; Gbinigie, Oghenekome Abisoye; Hayward, Gail; Holmes, Jane; Hood, Kerenza; Khoo, Saye; Ahmed, Haroon; Lown, Mark; Mckenna, Micheal; Mort, Sam; Nguyen-Van-Tam, Jonathan; Rahman, Najib; Richards, Duncan B; Thomas, Nicholas; van Hecke, Oliver; Hobbs, Fd Richard; Little, Paul; Yu, Ly-Mee; Butler, Christopher C; Petrou, Stavros.

Br J Gen Pract ; 2024 Jan 16.

Artigo em Inglês | MEDLINE | ID: mdl-38228357

11.

Randomized controlled trial of molnupiravir SARS-CoV-2 viral and antibody response in at-risk adult outpatients.

Standing, Joseph F; Buggiotti, Laura; Guerra-Assuncao, Jose Afonso; Woodall, Maximillian; Ellis, Samuel; Agyeman, Akosua A; Miller, Charles; Okechukwu, Mercy; Kirkpatrick, Emily; Jacobs, Amy I; Williams, Charlotte A; Roy, Sunando; Martin-Bernal, Luz M; Williams, Rachel; Smith, Claire M; Sanderson, Theo; Ashford, Fiona B; Emmanuel, Beena; Afzal, Zaheer M; Shields, Adrian; Richter, Alex G; Dorward, Jienchi; Gbinigie, Oghenekome; Van Hecke, Oliver; Lown, Mark; Francis, Nick; Jani, Bhautesh; Richards, Duncan B; Rahman, Najib M; Yu, Ly-Mee; Thomas, Nicholas P B; Hart, Nigel D; Evans, Philip; Andersson, Monique; Hayward, Gail; Hood, Kerenza; Nguyen-Van-Tam, Jonathan S; Little, Paul; Hobbs, F D Richard; Khoo, Saye; Butler, Christopher; Lowe, David M; Breuer, Judith.

Nat Commun ; 15(1): 1652, 2024 Feb 23.

Artigo em Inglês | MEDLINE | ID: mdl-38396069

12.

Guidance on C-reactive protein point-of-care testing and complementary strategies to improve antibiotic prescribing for adults with lower respiratory tract infections in primary care.

Van Hecke, Oliver; Bjerrum, Lars; Gentile, Ivan; Hopstaken, Rogier; Melbye, Hasse; Plate, Andreas; Verbakel, Jan Y; Llor, Carl; Staiano, Annamaria.

Front Med (Lausanne) ; 10: 1166742, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-37324137

13.

C-reactive protein point-of-care testing and complementary strategies to improve antibiotic stewardship in children with acute respiratory infections in primary care.

Staiano, Annamaria; Bjerrum, Lars; Llor, Carl; Melbye, Hasse; Hopstaken, Rogier; Gentile, Ivan; Plate, Andreas; van Hecke, Oliver; Verbakel, Jan Y.

Front Pediatr ; 11: 1221007, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-37900677

14.

Platform adaptive trial of novel antivirals for early treatment of COVID-19 In the community (PANORAMIC): protocol for a randomised, controlled, open-label, adaptive platform trial of community novel antiviral treatment of COVID-19 in people at increased risk of more severe disease.

Gbinigie, Oghenekome; Ogburn, Emma; Allen, Julie; Dorward, Jienchi; Dobson, Melissa; Madden, Tracie-Ann; Yu, Ly-Mee; Lowe, David M; Rahman, Najib; Petrou, Stavros; Richards, Duncan; Hood, Kerenza; Patel, Mahendra; Saville, Benjamin R; Marion, Joe; Holmes, Jane; Png, May Ee; Hayward, Gail; Lown, Mark; Harris, Victoria; Jani, Bhautesh; Hart, Nigel; Khoo, Saye; Rutter, Heather; Chalk, Jem; Standing, Joseph F; Breuer, Judith; Lavallee, Layla; Hadley, Elizabeth; Cureton, Lucy; Benysek, Magdalena; Andersson, Monique I; Francis, Nick; Thomas, Nicholas P B; Evans, Philip; van Hecke, Oliver; Koshkouei, Mona; Coates, Maria; Barrett, Sarah; Bateman, Clare; Davies, Jennifer; Raymundo-Wood, Ivy; Ustianowski, Andrew; Nguyen-Van-Tam, Jonathan; Carson-Stevens, Andrew; Hobbs, Richard; Little, Paul; Butler, Christopher C.

BMJ Open ; 13(8): e069176, 2023 08 07.

Artigo em Inglês | MEDLINE | ID: mdl-37550022

15.

General practices that reduce antibiotic prescribing for self-limiting respiratory tract infections by 10% can expect to see one extra patient with pneumonia each year and one peritonsillar abscess each decade.

van Hecke, Oliver; Butler, Chris C.

Evid Based Med ; 22(2): 66-67, 2017 04.

Artigo em Inglês | MEDLINE | ID: mdl-28053202

16.

Point-of-care diagnostic technology in paediatric ambulatory care: a qualitative interview study of English clinicians and stakeholders.

Raymond, Meriel Elizabeth; Bird, Chris; van Hecke, Oliver; Glogowska, Margaret; Hayward, Gail.

BMJ Open ; 12(6): e059103, 2022 06 07.

Artigo em Inglês | MEDLINE | ID: mdl-35672068

17.

Role of locum GPs in antibiotic prescribing and stewardship: a mixed-methods study.

Borek, Aleksandra J; Pouwels, Koen B; van Hecke, Oliver; Robotham, Julie V; Butler, Christopher C; Tonkin-Crine, Sarah.

Br J Gen Pract ; 72(715): e118-e127, 2022 02.

Artigo em Inglês | MEDLINE | ID: mdl-34990397

18.

Colchicine for COVID-19 in the community (PRINCIPLE): a randomised, controlled, adaptive platform trial.

Dorward, Jienchi; Yu, Ly-Mee; Hayward, Gail; Saville, Benjamin R; Gbinigie, Oghenekome; Van Hecke, Oliver; Ogburn, Emma; Evans, Philip H; Thomas, Nicholas Pb; Patel, Mahendra G; Richards, Duncan; Berry, Nicholas; Detry, Michelle A; Saunders, Christina; Fitzgerald, Mark; Harris, Victoria; Shanyinde, Milensu; de Lusignan, Simon; Andersson, Monique I; Butler, Christopher C; Hobbs, Fd Richard.

Br J Gen Pract ; 72(720): e446-e455, 2022 07.

Artigo em Inglês | MEDLINE | ID: mdl-35440469

19.

Polymyalgia rheumatica -- diagnosis and management.

van Hecke, Oliver.

Aust Fam Physician ; 40(5): 303-6, 2011 May.

Artigo em Inglês | MEDLINE | ID: mdl-21597550

20.

Exploring Primary Care Clinicians' Views about How Best to Implement a Potential Trial around Point-of-Care Tests for Common Infections in South Africa.

Epps, Alice; Albury, Charlotte; Van Hecke, Oliver.

Diagnostics (Basel) ; 11(11)2021 Nov 13.

Artigo em Inglês | MEDLINE | ID: mdl-34829447

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