RESUMO
The brine shrimp, Artemia franciscana, has a body plan composed of 11 thoracic segments, followed by 2 genital segments, and then 6 additional abdominal segments. Previous studies of Artemia reported that expression of the posterior-most Hox gene, Abdominal-B (Abd-B), is restricted to the genital segments and is not observed posteriorly in the abdomen at any developmental stage. This report was remarkable because it suggested that the Artemia abdomen posterior to the genital segments was a novel body region of 6 segments that bore no homology to any region in other crustaceans and was unique amongst arthropods in being a Hox-free segmented domain outside of the head. In this study, we used RT-PCR, antibody staining, and in situ hybridization on various stages of Artemia nauplii to show that Abd-B mRNA and protein are in fact expressed throughout the abdominal segments during Artemia development, but this expression later retracts to the two genital segments (G1, G2) and the T11 appendages. This suggests that Abd-B does play a role in specifying abdominal segment identity in all crustaceans that have been examined and suggests a common evolutionary origin for the crustacean abdomen.
Assuntos
Artemia , Proteínas de Homeodomínio , Abdome , Animais , Artemia/genética , Artemia/metabolismo , Regulação da Expressão Gênica no Desenvolvimento , Proteínas de Homeodomínio/metabolismo , Fatores de Transcrição/metabolismoRESUMO
Cytoplasmic condensates that mimic nuclear pore complexes entice viruses away from the nucleus.
Assuntos
Poro Nuclear , Poro Nuclear/metabolismo , Humanos , Núcleo Celular/metabolismo , Núcleo Celular/virologia , Animais , Condensados Biomoleculares/metabolismo , Condensados Biomoleculares/químicaRESUMO
The taurine metabolite N-acetyltaurine protects mice from diet-induced obesity by reducing food intake.
Assuntos
Obesidade , Taurina , Taurina/farmacologia , Taurina/metabolismo , Animais , Obesidade/metabolismo , Obesidade/tratamento farmacológico , Camundongos , Apetite/efeitos dos fármacos , Humanos , Ingestão de Alimentos/efeitos dos fármacosRESUMO
Bacterial LPS disrupts the blood-brain barrier by inducing endothelial cell pyroptosis.
Assuntos
Barreira Hematoencefálica , Células Endoteliais , Lipopolissacarídeos , Barreira Hematoencefálica/metabolismo , Barreira Hematoencefálica/microbiologia , Humanos , Lipopolissacarídeos/metabolismo , Animais , Células Endoteliais/metabolismo , Células Endoteliais/microbiologia , Piroptose , Bactérias/metabolismoRESUMO
The orphan nuclear receptor ERRγ directs the differentiation of acid-secreting gastric cells.
Assuntos
Diferenciação Celular , Células Parietais Gástricas , Receptores de Estrogênio , Animais , Células Parietais Gástricas/metabolismo , Receptores de Estrogênio/metabolismo , Camundongos , HumanosRESUMO
Displacement of the glycocalyx by membrane blebbing enables macrophages to recognize apoptotic cells.
Assuntos
Apoptose , Glicocálix , Macrófagos , Humanos , Glicocálix/metabolismo , Animais , Macrófagos/metabolismo , Macrófagos/citologia , Fagócitos/metabolismo , Fagócitos/citologia , Fagocitose , CamundongosRESUMO
The extracellular WNT-binding proteins SFRP and WIF1 promote and inhibit WNT signaling.
Assuntos
Proteínas Adaptadoras de Transdução de Sinal , Proteínas Wnt , Proteínas Adaptadoras de Transdução de Sinal/metabolismo , Proteínas Wnt/metabolismo , Via de Sinalização WntRESUMO
Antibiotic-induced loss of intestinal hypoxia boosts the growth of C. albicans in mice.
Assuntos
Candida albicans , Hipóxia , Animais , Camundongos , Hipóxia/metabolismo , Candida albicans/metabolismo , Antibacterianos/farmacologia , Candidíase/microbiologia , Candidíase/prevenção & controle , Candidíase/metabolismo , Intestinos/microbiologia , HumanosRESUMO
Highlights from the Science family of journals.
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Highlights from the Science family of journals.
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Highlights from the Science family of journals.
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Highlights from the Science family of journals.
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Highlights from the Science family of journals.
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Highlights from the Science family of journals.
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Highlights from the Science family of journals.
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Highlights from the Science family of journals.
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Highlights from the Science family of journals.
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Senescent cells in naked mole-rats are eliminated by apoptosis.
Assuntos
Ratos-Toupeira , AnimaisRESUMO
Asymmetric movement of a polycystin subunit may underlie the initial break in left-right asymmetry in mouse embryos.
RESUMO
Intestinal injury induces the outgrowth of adrenergic neurons that stimulate a proregenerative pathway.