Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Identification of the genetic mechanism that associates L3MBTL3 to multiple sclerosis.

Alcina, Antonio; Fedetz, Maria; Vidal-Cobo, Isabel; Andrés-León, Eduardo; García-Sánchez, Maria-Isabel; Barroso-Del-Jesus, Alicia; Eichau, Sara; Gil-Varea, Elia; Saiz, Albert; Leyva, Laura; Vandenbroeck, Koen; Otaegui, David; Izquierdo, Guillermo; Comabella, Manuel; Urcelay, Elena; Matesanz, Fuencisla.

Hum Mol Genet ; 31(13): 2155-2163, 2022 07 07.

Artigo em Inglês | MEDLINE | ID: mdl-35088080

2.

Boosting Cholesterol Efflux from Foam Cells by Sequential Administration of rHDL to Deliver MicroRNA and to Remove Cholesterol in a Triple-Cell 2D Atherosclerosis Model.

Jebari-Benslaiman, Shifa; Uribe, Kepa B; Benito-Vicente, Asier; Galicia-Garcia, Unai; Larrea-Sebal, Asier; Santin, Izortze; Alloza, Iraide; Vandenbroeck, Koen; Ostolaza, Helena; Martín, César.

Small ; 18(13): e2105915, 2022 04.

Artigo em Inglês | MEDLINE | ID: mdl-35156292

3.

Exome sequencing in multiple sclerosis families identifies 12 candidate genes and nominates biological pathways for the genesis of disease.

Vilariño-Güell, Carles; Zimprich, Alexander; Martinelli-Boneschi, Filippo; Herculano, Bruno; Wang, Zhe; Matesanz, Fuencisla; Urcelay, Elena; Vandenbroeck, Koen; Leyva, Laura; Gris, Denis; Massaad, Charbel; Quandt, Jacqueline A; Traboulsee, Anthony L; Encarnacion, Mary; Bernales, Cecily Q; Follett, Jordan; Yee, Irene M; Criscuoli, Maria G; Deutschländer, Angela; Reinthaler, Eva M; Zrzavy, Tobias; Mascia, Elisabetta; Zauli, Andrea; Esposito, Federica; Alcina, Antonio; Izquierdo, Guillermo; Espino-Paisán, Laura; Mena, Jorge; Antigüedad, Alfredo; Urbaneja-Romero, Patricia; Ortega-Pinazo, Jesús; Song, Weihong; Sadovnick, A Dessa.

PLoS Genet ; 15(6): e1008180, 2019 06.

Artigo em Inglês | MEDLINE | ID: mdl-31170158

4.

Pathophysiology of Atherosclerosis.

Jebari-Benslaiman, Shifa; Galicia-García, Unai; Larrea-Sebal, Asier; Olaetxea, Javier Rekondo; Alloza, Iraide; Vandenbroeck, Koen; Benito-Vicente, Asier; Martín, César.

Int J Mol Sci ; 23(6)2022 Mar 20.

Artigo em Inglês | MEDLINE | ID: mdl-35328769

5.

NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients.

Malhotra, Sunny; Costa, Carme; Eixarch, Herena; Keller, Christian W; Amman, Lukas; Martínez-Banaclocha, Helios; Midaglia, Luciana; Sarró, Eduard; Machín-Díaz, Isabel; Villar, Luisa M; Triviño, Juan Carlos; Oliver-Martos, Begoña; Parladé, Laura Navarro; Calvo-Barreiro, Laura; Matesanz, Fuencisla; Vandenbroeck, Koen; Urcelay, Elena; Martínez-Ginés, María-Luisa; Tejeda-Velarde, Amalia; Fissolo, Nicolás; Castilló, Joaquín; Sanchez, Alex; Robertson, Avril A B; Clemente, Diego; Prinz, Marco; Pelegrin, Pablo; Lünemann, Jan D; Espejo, Carmen; Montalban, Xavier; Comabella, Manuel.

Brain ; 143(5): 1414-1430, 2020 05 01.

Artigo em Inglês | MEDLINE | ID: mdl-32282893

6.

Novel Transcript Discovery Expands the Repertoire of Pathologically-Associated, Long Non-Coding RNAs in Vascular Smooth Muscle Cells.

Bennett, Matthew; Ulitsky, Igor; Alloza, Iraide; Vandenbroeck, Koen; Miscianinov, Vladislav; Mahmoud, Amira Dia; Ballantyne, Margaret; Rodor, Julie; Baker, Andrew H.

Int J Mol Sci ; 22(3)2021 Feb 02.

Artigo em Inglês | MEDLINE | ID: mdl-33540814

7.

BIRC6 Is Associated with Vulnerability of Carotid Atherosclerotic Plaque.

Alloza, Iraide; Salegi, Andrea; Mena, Jorge; Navarro, Raquel Tulloch; Martin, César; Aspichueta, Patricia; Salazar, Lucía Martínez; Carpio, Jon Uriarte; Cagigal, Patricia De-la-Hera; Vega, Reyes; Triviño, Juan Carlos; Freijo, Maria Del Mar; Vandenbroeck, Koen.

Int J Mol Sci ; 21(24)2020 Dec 09.

Artigo em Inglês | MEDLINE | ID: mdl-33317170

8.

Pharmacological Targeting of the ER-Resident Chaperones GRP94 or Cyclophilin B Induces Secretion of IL-22 Binding Protein Isoform-1 (IL-22BPi1).

Gómez-Fernández, Paloma; Urtasun, Andoni; Astobiza, Ianire; Mena, Jorge; Alloza, Iraide; Vandenbroeck, Koen.

Int J Mol Sci ; 20(10)2019 May 17.

Artigo em Inglês | MEDLINE | ID: mdl-31108847

9.

Novel Insights into the Multiple Sclerosis Risk Gene ANKRD55.

Lopez de Lapuente, Aitzkoa; Feliú, Ana; Ugidos, Nerea; Mecha, Miriam; Mena, Jorge; Astobiza, Ianire; Riera, José; Carrillo-Salinas, Francisco J.; Comabella, Manuel; Montalban, Xavier; Alloza, Iraide; Guaza, Carmen; Vandenbroeck, Koen.

J Immunol ; 196(11): 4553-65, 2016 06 01.

Artigo em Inglês | MEDLINE | ID: mdl-27183579

10.

A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis.

Matesanz, Fuencisla; Potenciano, Victor; Fedetz, Maria; Ramos-Mozo, Priscila; Abad-Grau, María del Mar; Karaky, Mohamad; Barrionuevo, Cristina; Izquierdo, Guillermo; Ruiz-Peña, Juan Luis; García-Sánchez, María Isabel; Lucas, Miguel; Fernández, Óscar; Leyva, Laura; Otaegui, David; Muñoz-Culla, Maider; Olascoaga, Javier; Vandenbroeck, Koen; Alloza, Iraide; Astobiza, Ianire; Antigüedad, Alfredo; Villar, Luisa María; Álvarez-Cermeño, José Carlos; Malhotra, Sunny; Comabella, Manuel; Montalban, Xavier; Saiz, Albert; Blanco, Yolanda; Arroyo, Rafael; Varadé, Jezabel; Urcelay, Elena; Alcina, Antonio.

Hum Mol Genet ; 24(19): 5619-27, 2015 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-26152201

11.

Cell-specific effects in different immune subsets associated with SOCS1 genotypes in multiple sclerosis.

Lopez de Lapuente, Aitzkoa; Pinto-Medel, María Jesús; Astobiza, Ianire; Alloza, Iraide; Comabella, Manuel; Malhotra, Sunny; Montalban, Xavier; Zettl, Uwe K; Rodríguez-Antigüedad, Alfredo; Fernández, Oscar; Vandenbroeck, Koen.

Mult Scler ; 21(12): 1498-512, 2015 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-25623250

12.

MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis.

Lill, Christina M; Schjeide, Brit-Maren M; Graetz, Christine; Ban, Maria; Alcina, Antonio; Ortiz, Miguel A; Pérez, Jennifer; Damotte, Vincent; Booth, David; Lopez de Lapuente, Aitzkoa; Broer, Linda; Schilling, Marcel; Akkad, Denis A; Aktas, Orhan; Alloza, Iraide; Antigüedad, Alfredo; Arroyo, Rafa; Blaschke, Paul; Buttmann, Mathias; Chan, Andrew; Compston, Alastair; Cournu-Rebeix, Isabelle; Dörner, Thomas; Epplen, Joerg T; Fernández, Óscar; Gerdes, Lisa-Ann; Guillot-Noël, Léna; Hartung, Hans-Peter; Hoffjan, Sabine; Izquierdo, Guillermo; Kemppinen, Anu; Kroner, Antje; Kubisch, Christian; Kümpfel, Tania; Li, Shu-Chen; Lindenberger, Ulman; Lohse, Peter; Lubetzki, Catherine; Luessi, Felix; Malhotra, Sunny; Mescheriakova, Julia; Montalban, Xavier; Papeix, Caroline; Paredes, Lidia F; Rieckmann, Peter; Steinhagen-Thiessen, Elisabeth; Winkelmann, Alexander; Zettl, Uwe K; Hintzen, Rogier; Vandenbroeck, Koen.

Brain ; 136(Pt 6): 1778-82, 2013 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-23739915

13.

Identification of a functional variant in the KIF5A-CYP27B1-METTL1-FAM119B locus associated with multiple sclerosis.

Alcina, Antonio; Fedetz, Maria; Fernández, Oscar; Saiz, Albert; Izquierdo, Guillermo; Lucas, Miguel; Leyva, Laura; García-León, Juan-Antonio; Abad-Grau, María Del Mar; Alloza, Iraide; Antigüedad, Alfredo; Garcia-Barcina, María J; Vandenbroeck, Koen; Varadé, Jezabel; de la Hera, Belén; Arroyo, Rafael; Comabella, Manuel; Montalban, Xavier; Petit-Marty, Natalia; Navarro, Arcadi; Otaegui, David; Olascoaga, Javier; Blanco, Yolanda; Urcelay, Elena; Matesanz, Fuencisla.

J Med Genet ; 50(1): 25-33, 2013 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-23160276

14.

The era of GWAS is over - Yes.

Vandenbroeck, Koen.

Mult Scler ; 24(3): 256-257, 2018 03.

Artigo em Inglês | MEDLINE | ID: mdl-29251250

15.

Correction: Novel Insights into the Multiple Sclerosis Risk Gene ANKRD55.

Lopez de Lapuente, Aitzkoa; Feliú, Ana; Ugidos, Nerea; Mecha, Miriam; Mena, Jorge; Astobiza, Ianire; Riera, José; Carrillo-Salinas, Francisco J; Comabella, Manuel; Montalban, Xavier; Alloza, Iraide; Guaza, Carmen; Vandenbroeck, Koen.

J Immunol ; 197(10): 4177, 2016 11 15.

Artigo em Inglês | MEDLINE | ID: mdl-27815448

16.

Closing the case of APOE in multiple sclerosis: no association with disease risk in over 29 000 subjects.

Lill, Christina M; Liu, Tian; Schjeide, Brit-Maren M; Roehr, Johannes T; Akkad, Denis A; Damotte, Vincent; Alcina, Antonio; Ortiz, Miguel A; Arroyo, Rafa; Lopez de Lapuente, Aitzkoa; Blaschke, Paul; Winkelmann, Alexander; Gerdes, Lisa-Ann; Luessi, Felix; Fernadez, Oscar; Izquierdo, Guillermo; Antigüedad, Alfredo; Hoffjan, Sabine; Cournu-Rebeix, Isabelle; Gromöller, Silvana; Faber, Hans; Liebsch, Maria; Meissner, Esther; Chanvillard, Coralie; Touze, Emmanuel; Pico, Fernando; Corcia, Philippe; Dörner, Thomas; Steinhagen-Thiessen, Elisabeth; Baeckman, Lars; Heekeren, Hauke R; Li, Shu-Chen; Lindenberger, Ulman; Chan, Andrew; Hartung, Hans-Peter; Aktas, Orhan; Lohse, Peter; Kümpfel, Tania; Kubisch, Christian; Epplen, Joerg T; Zettl, Uwe K; Fontaine, Bertrand; Vandenbroeck, Koen; Matesanz, Fuencisla; Urcelay, Elena; Bertram, Lars; Zipp, Frauke.

J Med Genet ; 49(9): 558-62, 2012 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-22972946

17.

Replication study of 10 genes showing evidence for association with multiple sclerosis: validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes.

Varadé, Jezabel; Comabella, Manuel; Ortiz, Miguel A; Arroyo, Rafael; Fernández, Oscar; Pinto-Medel, M Jesús; Fedetz, María; Izquierdo, Guillermo; Lucas, Miguel; Gómez, Carlos López; Rabasa, Antonio Catalá; Alcina, Antonio; Matesanz, Fuencisla; Alloza, Iraide; Antigüedad, Alfredo; García-Barcina, María; Otaegui, David; Olascoaga, Javier; Saiz, Albert; Blanco, Yolanda; Montalbán, Xavier; Vandenbroeck, Koen; Urcelay, Elena.

Mult Scler ; 18(7): 959-65, 2012 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-22194214

18.

Inhibition of secretion of interleukin (IL)-12/IL-23 family cytokines by 4-trifluoromethyl-celecoxib is coupled to degradation via the endoplasmic reticulum stress protein HERP.

McLaughlin, Martin; Alloza, Iraide; Quoc, Hung Pham; Scott, Christopher J; Hirabayashi, Yasuhiko; Vandenbroeck, Koen.

J Biol Chem ; 285(10): 6960-9, 2010 Mar 05.

Artigo em Inglês | MEDLINE | ID: mdl-20054003

19.

Pharmacogenomics and multiple sclerosis: moving toward individualized medicine.

Comabella, Manuel; Vandenbroeck, Koen.

Curr Neurol Neurosci Rep ; 11(5): 484-91, 2011 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-21701907

20.

Genomic Multiple Sclerosis Risk Variants Modulate the Expression of the ANKRD55-IL6ST Gene Region in Immature Dendritic Cells.

Mena, Jorge; Alloza, Iraide; Tulloch Navarro, Raquel; Aldekoa, Ane; Díez García, Javier; Villanueva Etxebarria, Ane; Lindskog, Cecilia; Antigüedad, Alfredo; Boyero, Sabas; Mendibe-Bilbao, María Del Mar; Álvarez de Arcaya, Amaya; Sánchez Menoyo, José Luis; Midaglia, Luciana; Villarrubia, Noelia; Malhotra, Sunny; Montalban, Xavier; Villar, Luisa María; Comabella, Manuel; Vandenbroeck, Koen.

Front Immunol ; 12: 816930, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-35111166

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