Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Glucosylated hydroxymethyluracil, DNA base J, prevents transcriptional readthrough in Leishmania.

van Luenen, Henri G A M; Farris, Carol; Jan, Sabrina; Genest, Paul-Andre; Tripathi, Pankaj; Velds, Arno; Kerkhoven, Ron M; Nieuwland, Marja; Haydock, Andrew; Ramasamy, Gowthaman; Vainio, Saara; Heidebrecht, Tatjana; Perrakis, Anastassis; Pagie, Ludo; van Steensel, Bas; Myler, Peter J; Borst, Piet.

Cell ; 150(5): 909-21, 2012 Aug 31.

Artigo em Inglês | MEDLINE | ID: mdl-22939620

2.

The phosphatase inhibitor LB-100 creates neoantigens in colon cancer cells through perturbation of mRNA splicing.

Dias, Matheus H; Liudkovska, Vladyslava; Montenegro Navarro, Jasmine; Giebel, Lisanne; Champagne, Julien; Papagianni, Chrysa; Bleijerveld, Onno B; Velds, Arno; Agami, Reuven; Bernards, René; Ciesla, Maciej.

EMBO Rep ; 25(5): 2220-2238, 2024 May.

Artigo em Inglês | MEDLINE | ID: mdl-38600345

3.

BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance.

Duarte, Alexandra A; Gogola, Ewa; Sachs, Norman; Barazas, Marco; Annunziato, Stefano; R de Ruiter, Julian; Velds, Arno; Blatter, Sohvi; Houthuijzen, Julia M; van de Ven, Marieke; Clevers, Hans; Borst, Piet; Jonkers, Jos; Rottenberg, Sven.

Nat Methods ; 15(2): 134-140, 2018 02.

Artigo em Inglês | MEDLINE | ID: mdl-29256493

4.

Reassessing genomic targeting of AID.

Hogenbirk, Marc A; Velds, Arno; Kerkhoven, Ron M; Jacobs, Heinz.

Nat Immunol ; 13(9): 797-8; author reply 798-800, 2012 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-22910380

5.

Defining chromosomal translocation risks in cancer.

Hogenbirk, Marc A; Heideman, Marinus R; de Rink, Iris; Velds, Arno; Kerkhoven, Ron M; Wessels, Lodewyk F A; Jacobs, Heinz.

Proc Natl Acad Sci U S A ; 113(26): E3649-56, 2016 06 28.

Artigo em Inglês | MEDLINE | ID: mdl-27303044

6.

XenofilteR: computational deconvolution of mouse and human reads in tumor xenograft sequence data.

Kluin, Roelof J C; Kemper, Kristel; Kuilman, Thomas; de Ruiter, Julian R; Iyer, Vivek; Forment, Josep V; Cornelissen-Steijger, Paulien; de Rink, Iris; Ter Brugge, Petra; Song, Ji-Ying; Klarenbeek, Sjoerd; McDermott, Ultan; Jonkers, Jos; Velds, Arno; Adams, David J; Peeper, Daniel S; Krijgsman, Oscar.

BMC Bioinformatics ; 19(1): 366, 2018 Oct 04.

Artigo em Inglês | MEDLINE | ID: mdl-30286710

7.

Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division.

Maia, Ana Rita R; Linder, Simon; Song, Ji-Ying; Vaarting, Chantal; Boon, Ute; Pritchard, Colin E J; Velds, Arno; Huijbers, Ivo J; van Tellingen, Olaf; Jonkers, Jos; Medema, René H.

Br J Cancer ; 118(12): 1586-1595, 2018 06.

Artigo em Inglês | MEDLINE | ID: mdl-29736010

8.

Reproducibility of Illumina platform deep sequencing errors allows accurate determination of DNA barcodes in cells.

Beltman, Joost B; Urbanus, Jos; Velds, Arno; van Rooij, Nienke; Rohr, Jan C; Naik, Shalin H; Schumacher, Ton N.

BMC Bioinformatics ; 17: 151, 2016 Apr 02.

Artigo em Inglês | MEDLINE | ID: mdl-27038897

9.

BRCA1-like profile predicts benefit of tandem high dose epirubicin-cyclophospamide-thiotepa in high risk breast cancer patients randomized in the WSG-AM01 trial.

Schouten, Philip C; Gluz, Oleg; Harbeck, Nadia; Mohrmann, Svjetlana; Diallo-Danebrock, Raihana; Pelz, Enrico; Kruizinga, Janneke; Velds, Arno; Nieuwland, Marja; Kerkhoven, Ron M; Liedtke, Cornelia; Frick, Markus; Kates, Ronald; Linn, Sabine C; Nitz, Ulrike; Marme, Frederik.

Int J Cancer ; 139(4): 882-9, 2016 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-26946057

10.

Dosage-dependent tumor suppression by histone deacetylases 1 and 2 through regulation of c-Myc collaborating genes and p53 function.

Heideman, Marinus R; Wilting, Roel H; Yanover, Eva; Velds, Arno; de Jong, Johann; Kerkhoven, Ron M; Jacobs, Heinz; Wessels, Lodewyk F; Dannenberg, Jan-Hermen.

Blood ; 121(11): 2038-50, 2013 Mar 14.

Artigo em Inglês | MEDLINE | ID: mdl-23327920

11.

Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse.

Chen, Mengnuo; Mainardi, Sara; Lieftink, Cor; Velds, Arno; de Rink, Iris; Yang, Chen; Kuiken, Hendrik J; Morris, Ben; Edwards, Finn; Jochems, Fleur; van Tellingen, Olaf; Boeije, Manon; Proost, Natalie; Jansen, Robin A; Qin, Shifan; Jin, Haojie; Koen van der Mijn, J C; Schepers, Arnout; Venkatesan, Subramanian; Qin, Wenxin; Beijersbergen, Roderick L; Wang, Liqin; Bernards, René.

Cell Rep Med ; 5(3): 101471, 2024 Mar 19.

Artigo em Inglês | MEDLINE | ID: mdl-38508142

12.

DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age.

Urbanus, Jos; Cosgrove, Jason; Beltman, Joost B; Elhanati, Yuval; Moral, Rafael A; Conrad, Cecile; van Heijst, Jeroen W; Tubeuf, Emilie; Velds, Arno; Kok, Lianne; Merle, Candice; Magnusson, Jens P; Guyonnet, Léa; Frisén, Jonas; Fre, Silvia; Walczak, Aleksandra M; Mora, Thierry; Jacobs, Heinz; Schumacher, Ton N; Perié, Leïla.

Nat Commun ; 14(1): 2184, 2023 04 17.

Artigo em Inglês | MEDLINE | ID: mdl-37069150

13.

Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer.

Michalides, Rob; Griekspoor, Alexander; Balkenende, Astrid; Verwoerd, Desiree; Janssen, Lennert; Jalink, Kees; Floore, Arno; Velds, Arno; van't Veer, Laura; Neefjes, Jacques.

Cancer Cell ; 5(6): 597-605, 2004 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-15193262

14.

Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity.

Pogacar, Ziva; Johnson, Jackie L; Krenning, Lenno; De Conti, Giulia; Jochems, Fleur; Lieftink, Cor; Velds, Arno; Wardak, Leyma; Groot, Kelvin; Schepers, Arnout; Wang, Liqin; Song, Ji-Ying; van de Ven, Marieke; van Tellingen, Olaf; Medema, Rene H; Beijersbergen, Roderick L; Bernards, Rene; Leite de Oliveira, Rodrigo.

PLoS One ; 17(9): e0273182, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-36067171

15.

Genetic and compound screens uncover factors modulating cancer cell response to indisulam.

Pogacar, Ziva; Groot, Kelvin; Jochems, Fleur; Dos Santos Dias, Matheus; Mulero-Sánchez, Antonio; Morris, Ben; Roosen, Mieke; Wardak, Leyma; De Conti, Giulia; Velds, Arno; Lieftink, Cor; Thijssen, Bram; Beijersbergen, Roderick L; Bernards, René; Leite de Oliveira, Rodrigo.

Life Sci Alliance ; 5(9)2022 09.

Artigo em Inglês | MEDLINE | ID: mdl-35534224

16.

Patient-Derived Organoid Models of Human Neuroendocrine Carcinoma.

Dijkstra, Krijn K; van den Berg, José G; Weeber, Fleur; van de Haar, Joris; Velds, Arno; Kaing, Sovann; Peters, Dennis D G C; Eskens, Ferry A L M; de Groot, Derk-Jan A; Tesselaar, Margot E T; Voest, Emile E.

Front Endocrinol (Lausanne) ; 12: 627819, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-33776923

17.

BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations.

Holstege, Henne; Horlings, Hugo M; Velds, Arno; Langerød, Anita; Børresen-Dale, Anne-Lise; van de Vijver, Marc J; Nederlof, Petra M; Jonkers, Jos.

BMC Cancer ; 10: 654, 2010 Nov 30.

Artigo em Inglês | MEDLINE | ID: mdl-21118481

18.

Cross-species comparison of aCGH data from mouse and human BRCA1- and BRCA2-mutated breast cancers.

Holstege, Henne; van Beers, Erik; Velds, Arno; Liu, Xiaoling; Joosse, Simon A; Klarenbeek, Sjoerd; Schut, Eva; Kerkhoven, Ron; Klijn, Christiaan N; Wessels, Lodewyk F A; Nederlof, Petra M; Jonkers, Jos.

BMC Cancer ; 10: 455, 2010 Aug 24.

Artigo em Inglês | MEDLINE | ID: mdl-20735817

19.

A large-scale RNAi screen in human cells identifies new components of the p53 pathway.

Berns, Katrien; Hijmans, E Marielle; Mullenders, Jasper; Brummelkamp, Thijn R; Velds, Arno; Heimerikx, Mike; Kerkhoven, Ron M; Madiredjo, Mandy; Nijkamp, Wouter; Weigelt, Britta; Agami, Reuven; Ge, Wei; Cavet, Guy; Linsley, Peter S; Beijersbergen, Roderick L; Bernards, René.

Nature ; 428(6981): 431-7, 2004 Mar 25.

Artigo em Inglês | MEDLINE | ID: mdl-15042092

20.

Volatile anesthetics modulate gene expression in breast and brain tumor cells.

Huitink, Johannes M; Heimerikxs, Mike; Nieuwland, Marja; Loer, Stephan A; Brugman, Wim; Velds, Arno; Sie, Daoud; Kerkhoven, Ron M.

Anesth Analg ; 111(6): 1411-5, 2010 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-20889943

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