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PURPOSE: Here, we conducted a meta-analysis to explore the use of intraoperative ultrasound (iUS)-guided resection in patients diagnosed with high-grade glioma (HGG) or glioblastoma (GBM). Our aim was to determine whether iUS improves clinical outcomes compared to conventional neuronavigation (CNN). METHODS: Databases were searched until April 21, 2023 for randomized controlled trials (RCTs) and observational cohort studies that compared surgical outcomes for patients with HGG or GBM with the use of either iUS in addition to standard approach or CNN. The primary outcome was overall survival (OS). Secondary outcomes include volumetric extent of resection (EOR), gross total resection (GTR), and progression-free survival (PFS). Outcomes were analyzed by determining pooled relative risk ratios (RR), mean difference (MD), and standardized mean difference (SMD) using random-effects model. RESULTS: Of the initial 867 articles, only 7 articles specifically met the inclusion criteria (1 RCT and 6 retrospective cohorts). The analysis included 732 patients. Compared to CNN, the use of iUS was associated with higher OS (SMD = 0.26,95%CI=[0.12,0.39]) and GTR (RR = 2.02; 95% CI=[1.31,3.1]) for both HGG and GBM. There was no significant difference in PFS or EOR. CONCLUSION: The use of iUS in surgical resections for HGG and GBM can improve OS and GTR compared to CNN, but it did not affect PFS. These results suggest that iUS reduces mortality associated with HGG and GBM but not the risk of recurrence. These results can provide valuable cost-effective interventions for neurosurgeons in HGG and GBM surgery.
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Glioblastoma , Glioma , Humanos , Glioblastoma/diagnóstico por imagem , Glioblastoma/cirurgia , Glioma/diagnóstico por imagem , Glioma/cirurgia , Bases de Dados Factuais , Neuronavegação , NeurocirurgiõesRESUMO
Desmoplastic fibroma of bone is a very uncommon, benign but locally aggressive fibrogenic tumor. This report describes the case of a 45-year-old patient with a massive desmoplastic fibroma of the proximal tibia. A two-staged surgical procedure was successfully performed: wide resection and endoprosthetic reconstruction. Surgeons should be aware of the complexity of its treatment in the locally advanced and aggressive cases. A comprehensive review of the literature is also provided.
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CASE: A 79-year-old woman presented with a periprosthetic fracture 8 years after a total knee arthroplasty (TKA). Radiographs demonstrated tibial implant loosening with severe osteolysis. A high-grade osteosarcoma around the prosthesis was diagnosed, and a supracondylar femoral amputation was performed. After 2 years, no complications have occurred. CONCLUSIONS: A malignant tumor around a TKA is extremely rare. Surgeons should remain vigilant with patients who present with rapidly progressive or very aggressive implant loosening with osteolysis. Owing to its complexity and potentially devastating prognosis, treatment should be guided by a specialist multidisciplinary team. Complex limb salvage procedures or amputation is usually required.
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Artroplastia do Joelho , Neoplasias Ósseas , Osteossarcoma , Humanos , Feminino , Osteossarcoma/cirurgia , Osteossarcoma/diagnóstico por imagem , Artroplastia do Joelho/efeitos adversos , Idoso , Neoplasias Ósseas/cirurgia , Neoplasias Ósseas/diagnóstico por imagem , Amputação Cirúrgica , Fraturas Periprotéticas/etiologia , Fraturas Periprotéticas/cirurgia , Fraturas Periprotéticas/diagnóstico por imagem , Falha de PróteseRESUMO
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Abstract: Introduction Burnout Syndrome is considered by the WHO as a worker's risk, that causes mental and physical deterioration (headaches, gastrointestinal illness, high blood pressure, muscular tension and chronic fatigue). This is a result of chronic stress and of the workplace environment, which today is cold, hostile, demanding, both economically and psychologically. People are becoming cynical, with negative feelings toward their patients and their professional roll; they feel emotional exhaustion. This occurs frequently in health workers who deal with people who are dependent. What is the cause of this syndrome that is damaging the community of the workers? It is due to many facts, such as organizations where there is work overload (workload is a dimension of organizational life, this means productivity. In their scramble for increased productivity, organizations push people beyond what they can sustain, making work more intense, demanding more time and becoming more complex; this is the major risk factor, in which is shown an uncorrelation between the people and their work); lack of control (of the capacity to set priorities in their own work, to select and to make decisions regarding resources that are central in the professional roll; politics of the organization that interfere with this capacity, reduce individual autonomy an involvement with work); lack of reward (lack of community harmony, lack of fairness and also value conflict); breakdown of community (the loss of harmony in the community is made evident by greater conflicts among people, less mutual support and respect, and a growing sense of isolation); absence of fairness (trust, openness and respect, are all three, elements of fairness essential to maintain a person's engagement with work. Their absence contributes directly to burnout); conflicting valúes (this occurs when there is no correlation between the sources of workplace and the personal values, in some cases work overload makes people work with no ethics, causing them conflict with their own values). This syndrome has three dimensions: Exhaustion. When people experience exhaustion, they feel overextresed, both emotionally and physically; they feel drained, unable to recover, they don't sleep enough, and lack of energy needed to face new projects. Exhaustion is the first reaction to the stress of job demands or major change. Cynicism. They take a distant attitude toward work and the people on the job. They minimise their involvement at work and even give up their ideals. In some way, this is a form of protecting themselves from exhaustion and disappointment, persons feel it's safer to be indifferent, especially when the future is uncertain. Such a negative attitude can seriously damage a person's well-being and capacity to work. Ineffectiveness. Persons feel a growing sense of inadequacy, every project seems overwhelming, they think everybody conspires against them, and whatever they do, seems to be trivial. They lose confidence in themselves, and at the same time, others lose confidence in them. They become vulnerable to family strangements, and to abandon social activities, they tend to remain alone. By this time they can incur in drug abuse, become mentaly insane, and in extreme cases, comit suicide. The measurement instrument for the diagnosis of Burnout Syndrome is Maslach Burnout Inventory, which allows to sample large populations under this condition; it was developed by Maslach in 1976, and a large number of studies have been developed by this time. Chronic stress could have important effects on the quality of family relationships and have a negative influence in anesthesiology performance as well. Because of this important problem that affects physical condition of illness, mental health and performance and quality of medical services, and also because there are no studies in the anesthesiologist environment, we performed this study to asses burnout among anesthesiologist in the city of Mexicali, Baja California. The object of this study was to determine and evaluate the organizational factors associated to burnout, because anesthesiologist performs at surgery rooms, where they have to manage chronic and sustained stress; moreover they get involved with patients, and are exposed to organizational factors. Burnout may affect mental health, and thus, the performance of the anesthesiologist practice, fact that even may put in serious risk the life of patients. Material and methods Control and cases study was performed, universe included all anesthesiologist in Mexicali City (n=92), excluding thoses that are not active in anesthesiologist practice, and who refused to respond the surveys. Cases group was constituted by anesthesiologists with burnout syndrome and control group was constitute by anesthesiologists without burnout. Sampling was obtained by Cochran's formula obtaining n=28 for each group. Independent variables were vicious organizational factors (work overload, lack of control, lack of reward, breakdown of community, absence of fairness, conflicting values). Dependent variable was Burnout Syndrome. Valídate instruments use were Maslach's Inventory for diagnosis of Burnout and a general sociodemographic inventory, for risk factors. Statistic analysis performed were descriptive analysis, proportion tests for two populations, Odds ratios, and Chi2, at the same time Logistic regression was performed, the statistic program use was BMDP and Epi Info 6. Results First of all, we estimated the prevalence of burnout, excluding three anesthesiologists that refused to answer the inventory test, of 89 persons analyzed we obtained 37 cases, that gives us a prevalance of 44%. The group case was constituted by 23 males and five females, control group by 19 males and 9 females (p>0.05). Mean age of case group was 43.7 years; control group 45.8 years. Civil state for cases group was 85.7% married, 7.1% divorced, 3.5% single, 3.5% not married couple, for control group 71.4% married, 14.3% single, 7.1% widows and 7.1% not married couple; working time for case group range from 24 years to two years, mean age 13.5 years, control group range from 28 years to two years, mean age 16.4 years. For no organizational factors, being married or divorced was a risk for burnout with OR 5.20, having children's was a risk for burnout with OR 33.2, and having more years at work was also significant for developing burnout with OR 1.17. For organizational factors, the two variables for risk for burnout were work overload with p = 0.003, and conflicting values with p = 0.034, the other factors were no significant. Discussion The most important findings of the present study, were that work overload is a factor risk for burnout, this agrees with literature reports, where it is said that work overload is the factor that most affects health workers. In relation to conflicting values it also agrees with Maslach's studies, where the author says that this occurs where there is no correlation between work demand and moral values. In most cases, work overload can lead people to act with no ethics in their work, this creating conflicts with their moral values. In this study conflicting values result in being an protecting factor, considering Maslach's publishing, this is a form that health workers assume to try to protect themselves against exhaustion and deception, thus adopting the form of cynicism. The sieges we can find in this study is the honesty in the answers of the persons, besides this is assume by the inventory, this exist. Another siege is the sample size, but this was affront by an statistic manner. It is so important to continue with new investigation lines, because as long as a medical doctor has good mental and physical health, he will be apt to give qualified attention to patients. At the same time is important that organizations recognize this health problem, so they can provide psychiatric intervention for those medical doctors who are affected by this syndrome, and try also to reestructure their organization in order to avoid this problems.
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Objetivo: Obtener la prevalencia del Síndrome de Agotamiento Profesional en los médicos anestesiólogos de la ciudad de Mexicali, B.C. México. Material y Métodos: Se realizó un estudio poblacional, transversal y descriptivo, mediante cuestionario autoadministrado de Maslach a 92 médicos anestesiólogos de la ciudad de Mexicali, B.C., durante los meses de octubre del 2001 a febrero del 2002. Análisis estadístico: Chi cuadrada para las variables categóricas. Resultados: Se encuestaron a 22 mujeres y 67 hombres ( n = 89 ) obteniendo prevalencia de 44% con síndrome de agotamiento profesional, de los cuales 17% presentó alto grado de agotamiento emocional, 10% presentó alto grado de despersonalización y el 12.3% presentó baja realización personal. Conclusiones: De lo reportado por otros autores hay diferencias con nuestro estudio, posiblemente por corresponder a otras especialidades. Sugerimos estudios similares en otras ciudades del país para obtener prevalencia en este grupo de médicos especialistas.
Objective: To determine the prevalence of Burnout syndrome among anesthesiologists in Mexicali, Mexico. Study design: We carried out a descriptive, cross sectional study. Burnout syndrome was measured using the Maslach Burnout Inventory Human Services Survey (MBIHSS). We administered the inventory to 92 anesthesiologists between October 2001 and February 2002. Statistical analysis included Chi square tests for categorical variables. Results: 89 questionnaires were returned, 22 females and 67 males. Burnout prevalence was 44% divided as follows: 17% reported high emotional exhaustion, 12.3% reported symptoms compatible with depersonalization, and 10% experienced a sense of low personal accomplishment. Conclusions: Our study differs slightly from the literature, although this may be attributed to the medical specialty we chose to survey. We suggest similar studies be carried out in other cities in Mexico to be able to have comparison groups.
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Feminino , Humanos , Masculino , Anestesiologia , Esgotamento Profissional/epidemiologia , Estudos Transversais , México , PrevalênciaRESUMO
Las enfermedades cardiovasculares son de alta prevalencia en el hemisferio occidental incluyendo a la población colombiana. Se estima que las enfermedades cardiovasculares seguirán aumentando su prevalencia e incidencia en las décadas siguientes. Por esto, el mundo científico debe hacer un esfuerzo tanto para reducir la incidencia como también para mejorar los tratamientos para hacerlos mas efectivos y eficientes. La insuficiencia cardiaca hace parte de las enfermedades cardiovasculares de alta prevalencia en nuestro medio, y por tanto optimizar su tratamiento es una prioridad.
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Antagonistas Adrenérgicos beta , Angiotensinas , Bisoprolol , Doenças Cardiovasculares , Glicosídeos Digitálicos , Insuficiência Cardíaca , Metoprolol , Diuréticos , Contração Miocárdica , Retenção UrináriaRESUMO
Basados en la premisa una nutrición infantil es satisfactoria cuando los ritmos de crecimiento son adecuados, comparamos el patrón de crecimiento entre un grupo de recién nacidos alimentados al seno materno exclusivo y otro alimentado con fórmula modificada en proteínas, seleccionado de acuerdo con la tabla de números aleatorios. Se llevó a cabo un estudio descriptivo durante un periodo de seis meses en el Hospital de Ginecopediatría con Unidad de Medicina Familiar Núm. 31, Instituto Mexicano del Seguro Social, Mexicali, Baja California. Las mediciones de peso, talla y perímetro cefálico se efectuaron según las recomendaciones de National Center for Health Statistics y la Norma Oficial Mexicana. Para el análisis estadístico fueron utilizadas la prueba no paramétrica de porcentajes y la X² (alfa 0.05 y 95 por ciento intervalo de confianza para medias). En el análisis intragrupos, los lactantes alimentados con fórmula modificada presentaron la misma diferencia significativa (p < 0.05) de peso, talla y perímetro cefálico durante los primeros cuatro meses de vida; los alimentados al seno materno mostraron el mismo comportamiento en peso y talla, no así en perímetro cefálico, donde se encontró diferencias significativa (p < 0.05) exclusivamente los primeros tres meses. El primer trimestre de vida el aumento de la talla fue mayor en los lactantes alimentados con fórmula modificada (p <0.05), y el perímetro cefálico en los lactantes alimentados al seno materno (p < 0.05), pero al cuarto mes las dos variantes se igualaron en ambos grupos. El comportamiento del crecimiento durante los tres primeros meses de vida presentó diferencias en los dos grupos pero al final del estudio fue similar
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Humanos , Masculino , Feminino , Recém-Nascido , Lactente , Peso-Estatura , Aleitamento Materno , Antropometria , Substitutos do Leite Humano , Lactente , Nutrição do Lactente , Recém-Nascido/crescimento & desenvolvimentoRESUMO
Objetivo: determinar la asociación entre infec-ción cervicovaginal y trabajo de parto prematuro.Material y métodos: estudio de casos (n = 48) y controles (n = 48) en el área de admisión de Tococirugía del Hospital de Gineco-Pediatría con Unidad de Medicina Familiar 31, Instituto Mexicano del Seguro Social, Mexicali, Baja California, México. Resultados: por análisis univariado se encontró asociación entre infección global y trabajo de parto prematuro (p < 0.05 c2), al igual que desarrollo de Candida albicans en intensidad moderada y abundante (OR = 4.72). En análisis multivariado, la urosepsis y los antecedentes de aborto o parto prematuro se asociaron con trabajo de parto prematuro (p < 0.05 c2).Conclusiones: la infección cervicovaginal moderada o abundante por Candida albicans puede constituir un factor de riesgo para trabajo de parto prematuro. La infección de vías urinarias, los antecedentes de prematurez o aborto no mostraron relación entre sí o con otros factores de riesgo como los higiénicos, ambientales y laborales.
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Humanos , Feminino , Gravidez , Adolescente , Adulto , Previdência Social , Doenças Bacterianas Sexualmente Transmissíveis , Trabalho de Parto Prematuro , Estudos de Casos e Controles , Fatores de RiscoRESUMO
Se incluyeron 33 recién nacidos (RN) a término con antecedentes de ruptura prematura de membranas (RPM), hijos de madres sanas, a los que se les tomó muestras sanguíneas para biometría hemática, recuento leucocitario, relación B/N, plaquetas, y proteínas C reactiva; además se registró su sexo, Apgar al minuto y a los cinco minutos, el tiempo de ruptura, la cantidad eliminada de líquido amniótico y su evolución clínica. El Apgar al minuto fue de 8 y 9 a los 5 minutos. La RPM varió desde 12 hasta 96 horas (cuatro días) con una media de 22.4 horas. La cantidad de líquido amniótico al nacimiento fue adecuada en 29 casos, en cuatro se consideró disminuido. Los cuatro niños nacidos de estas mujeres fueron mantenidos en observación hasta obtener los resultados de exámenes. El recuento leucocitario reportó una media de 15,854, con una relación B/N que osciló de 0 a 0.125. Las plaquetas variaron entre 22,000 y 370,000 con una media de 210,393.9. La proteína C reactiva fue negativa en todos los niños, y en las evaluaciones clínicas no tuvieron signos características de infección. Los resultados concuerdan con lo informado en la literatura; muchos niños son tratados innecesariamente, por lo que es preciso documentar la infección mediante métodos sencillos. El empleo de antibióticos debe hacerse sólo en aquellos niños que se amerite