Detalhe da pesquisa
1.
Spontaneous Selection of Cryptosporidium Drug Resistance in a Calf Model of Infection.
Antimicrob Agents Chemother
; 65(6)2021 05 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33753338
2.
Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection.
Antimicrob Agents Chemother
; 63(4)2019 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30745384
3.
The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design.
Parasitology
; 145(2): 210-218, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29191253
4.
Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections.
Antimicrob Agents Chemother
; 61(11)2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28848016
5.
Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors.
Bioorg Med Chem Lett
; 27(12): 2702-2707, 2017 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28465105
6.
A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.
Acta Crystallogr D Biol Crystallogr
; 71(Pt 8): 1684-98, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26249349
7.
Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites.
Antimicrob Agents Chemother
; 59(11): 7128-31, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26324270
8.
A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.
J Infect Dis
; 209(2): 275-84, 2014 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24123773
9.
Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target.
Antimicrob Agents Chemother
; 57(7): 3021-8, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23587950
10.
Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents.
Bioorg Med Chem Lett
; 23(23): 6492-9, 2013 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24120539
11.
Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia.
Acta Crystallogr D Biol Crystallogr
; 68(Pt 9): 1194-200, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22948920
12.
Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.
Antimicrob Agents Chemother
; 56(9): 4914-21, 2012 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-22777048
13.
Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1.
Bioorg Med Chem Lett
; 22(16): 5264-7, 2012 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22795629
14.
Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice.
Antimicrob Agents Chemother
; 55(5): 1982-9, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21282428
15.
Screening a fragment cocktail library using ultrafiltration.
Anal Bioanal Chem
; 401(5): 1585-91, 2011 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-21750879
16.
Repurposing Infectious Disease Hits as Anti-Cryptosporidium Leads.
ACS Infect Dis
; 7(5): 1275-1282, 2021 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-33740373
17.
The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs.
J Struct Biol
; 171(2): 238-43, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20438846
18.
Prediction of protein crystallization outcome using a hybrid method.
J Struct Biol
; 171(1): 64-73, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20347992
19.
Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei.
RSC Med Chem
; 11(8): 885-895, 2020 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33479683
20.
Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies.
Mol Microbiol
; 68(1): 37-50, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18312275