Assuntos
Antibacterianos/uso terapêutico , Osteomielite/diagnóstico por imagem , Osteomielite/tratamento farmacológico , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Cintilografia , Base do Crânio , Idoso , Complicações do Diabetes/diagnóstico por imagem , Complicações do Diabetes/tratamento farmacológico , Feminino , Fluordesoxiglucose F18 , Humanos , Leucócitos , Masculino , Osteomielite/microbiologia , Compostos Radiofarmacêuticos , Estudos Retrospectivos , Tecnécio Tc 99m ExametazimaRESUMO
Eosinophilic granulomatosis with polyangiitis (EGPA) is an ANCA-associated vasculitis that affects small size vessels. Only four cases of periaortitis associated with EGPA have been reported in the literature. We report the case of a 67-year-old woman with EGPA who developed periaortitis 11 months after the initiation of dupilumab for uncontrolled asthma with hypereosinophilia. Complete remission of the periaortitis, and of EGPA, was obtained after switching from dupilumab to mepolizumab combined with oral prednisone therapy. Dupilumab has been associated with hypereosinophilia, that is usually asymptomatic and transitory, but symptomatic cases including EGPA were exceptionally reported. Although causality has not yet been established, caution is advisable when prescribing dupilumab for uncontrolled asthma with features that might suggest EGPA.