Detalhe da pesquisa
1.
Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability.
Antimicrob Agents Chemother
; 68(4): e0137323, 2024 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38380945
2.
Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors.
Bioorg Med Chem
; 24(21): 5534-5545, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27670099
3.
Iminopyrimidinones: a novel pharmacophore for the development of orally active renin inhibitors.
Bioorg Med Chem Lett
; 25(7): 1592-6, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25728416
4.
eCounterscreening: using QSAR predictions to prioritize testing for off-target activities and setting the balance between benefit and risk.
J Chem Inf Model
; 55(2): 231-8, 2015 Feb 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-25551659
5.
Discovery of potent iminoheterocycle BACE1 inhibitors.
Bioorg Med Chem Lett
; 24(23): 5455-9, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25455483
6.
Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE-1 inhibitors.
Top Curr Chem
; 317: 83-114, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-21647837
7.
Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity.
Bioorg Med Chem Lett
; 22(10): 3544-9, 2012 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22503250
8.
Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor.
Bioorg Med Chem Lett
; 22(7): 2444-9, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22390835
9.
Comparison of random forest and Pipeline Pilot Naïve Bayes in prospective QSAR predictions.
J Chem Inf Model
; 52(3): 792-803, 2012 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22360769
10.
Small-molecule inhibitors of FABP4/5 ameliorate dyslipidemia but not insulin resistance in mice with diet-induced obesity.
J Lipid Res
; 52(4): 646-56, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21296956
11.
Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors.
Bioorg Med Chem Lett
; 20(17): 5170-4, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20674350
12.
Iminoheterocycles as gamma-secretase modulators.
Bioorg Med Chem Lett
; 20(18): 5380-4, 2010 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20724152
13.
Piperazine sulfonamide BACE1 inhibitors: design, synthesis, and in vivo characterization.
Bioorg Med Chem Lett
; 20(9): 2837-42, 2010 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20347593
14.
Discovery of novel chemotypes to a G-protein-coupled receptor through ligand-steered homology modeling and structure-based virtual screening.
J Med Chem
; 51(3): 581-8, 2008 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18198821
15.
Initial evaluation of image performance of a 3-D x-ray system: phantom-based comparison of 3-D tomography with conventional computed tomography.
J Med Imaging (Bellingham)
; 5(1): 015502, 2018 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-29541651
16.
Initial Assessment of a Prototype 3D Cone-Beam Computed Tomography System for Imaging of the Lumbar Spine, Evaluating Human Cadaveric Specimens in the Upright Position.
Invest Radiol
; 53(12): 714-719, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30001256
17.
Identification of inhibitors to papillomavirus type 16 E6 protein based on three-dimensional structures of interacting proteins.
Antiviral Res
; 72(1): 49-59, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-16690141
18.
Structure-Based Design of an Iminoheterocyclic ß-Site Amyloid Precursor Protein Cleaving Enzyme (BACE) Inhibitor that Lowers Central Aß in Nonhuman Primates.
J Med Chem
; 59(7): 3231-48, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26937601
19.
Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)-A ß-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer's Disease.
J Med Chem
; 59(23): 10435-10450, 2016 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27933948
20.
Prosit, an online service to calculate pseudorotational parameters of nucleosides and nucleotides.
Nucleosides Nucleotides Nucleic Acids
; 24(5-7): 1029-32, 2005.
Artigo
em Inglês
| MEDLINE | ID: mdl-16248085