Detalhe da pesquisa
1.
A Pathogen-Selective Antibiotic Minimizes Disturbance to the Microbiome.
Antimicrob Agents Chemother
; 60(7): 4264-73, 2016 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27161626
2.
Cyclophilin inhibitors block arterivirus replication by interfering with viral RNA synthesis.
J Virol
; 87(3): 1454-64, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23152531
3.
Debio 0932, a new oral Hsp90 inhibitor, alleviates psoriasis in a xenograft transplantation model.
Acta Derm Venereol
; 94(6): 672-6, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24604074
4.
The cyclophilin inhibitor alisporivir prevents hepatitis C virus-mediated mitochondrial dysfunction.
Hepatology
; 55(5): 1333-43, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22135208
5.
Exploratory window-of-opportunity trial to investigate the tumor pharmacokinetics/pharmacodynamics of the IAP antagonist Debio 1143 in patients with head and neck cancer.
Clin Transl Sci
; 15(1): 55-62, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33742767
6.
Structural basis for the non-immunosuppressive character of the cyclosporin A analogue Debio 025.
Biochemistry
; 49(22): 4679-86, 2010 Jun 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20423153
7.
The isomerase active site of cyclophilin A is critical for hepatitis C virus replication.
J Biol Chem
; 284(25): 16998-17005, 2009 Jun 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-19380579
8.
HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A-cyclophilin A interaction to cyclophilin inhibitors.
J Hepatol
; 53(1): 50-6, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20451281
9.
Effect of neutrophil elastase and its inhibitor EPI-hNE4 on transepithelial sodium transport across normal and cystic fibrosis human nasal epithelial cells.
Respir Res
; 11: 141, 2010 Oct 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-20932306
10.
The inhibitor of apoptosis proteins antagonist Debio 1143 promotes the PD-1 blockade-mediated HIV load reduction in blood and tissues of humanized mice.
PLoS One
; 15(1): e0227715, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31978106
11.
Phase I Trial of Debio 1143, an Antagonist of Inhibitor of Apoptosis Proteins, Combined with Cisplatin Chemoradiotherapy in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck.
Clin Cancer Res
; 26(24): 6429-6436, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32994295
12.
Debio 025, a cyclophilin binding molecule, is highly efficient in clearing hepatitis C virus (HCV) replicon-containing cells when used alone or in combination with specifically targeted antiviral therapy for HCV (STAT-C) inhibitors.
Antimicrob Agents Chemother
; 53(3): 967-76, 2009 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19104013
13.
SMAC Mimetic Debio 1143 and Ablative Radiation Therapy Synergize to Enhance Antitumor Immunity against Lung Cancer.
Clin Cancer Res
; 25(3): 1113-1124, 2019 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30352911
14.
The inhibitor apoptosis protein antagonist Debio 1143 Is an attractive HIV-1 latency reversal candidate.
PLoS One
; 14(2): e0211746, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30716099
15.
Nuclear Imaging Study of the Pharmacodynamic Effects of Debio 1143, an Antagonist of Multiple Inhibitor of Apoptosis Proteins (IAPs), in a Triple-Negative Breast Cancer Model.
Contrast Media Mol Imaging
; 2018: 8494031, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30627061
16.
DEBIO 1143, an IAP inhibitor, reverses carboplatin resistance in ovarian cancer cells and triggers apoptotic or necroptotic cell death.
Sci Rep
; 8(1): 17862, 2018 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30552344
17.
HCV1b genome evolution under selective pressure of the cyclophilin inhibitor alisporivir during the DEB-025-HCV-203 phase II clinical trial.
Infect Genet Evol
; 44: 169-181, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27374748
18.
Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus Oocytes.
J Gen Physiol
; 120(2): 191-201, 2002 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-12149280
19.
The radiosensitizing activity of the SMAC-mimetic, Debio 1143, is TNFα-mediated in head and neck squamous cell carcinoma.
Radiother Oncol
; 116(3): 495-503, 2015 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-26096848
20.
SMAC mimetic Debio 1143 synergizes with taxanes, topoisomerase inhibitors and bromodomain inhibitors to impede growth of lung adenocarcinoma cells.
Oncotarget
; 6(35): 37410-25, 2015 Nov 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26485762