Detalhe da pesquisa
1.
Drug Combination Studies of the Dipeptide Nitrile CD24 with Curcumin: A New Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense.
Int J Mol Sci
; 23(22)2022 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36430948
2.
Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases-Studies on Inhibition Mechanism and Kinetics.
Molecules
; 25(9)2020 Apr 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32354191
3.
New Cysteine Protease Inhibitors: Electrophilic (Het)arenes and Unexpected Prodrug Identification for the Trypanosoma Protease Rhodesain.
Molecules
; 25(6)2020 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32210166
4.
Predicting 19 Fâ NMR Chemical Shifts: A Combined Computational and Experimental Study of a Trypanosomal Oxidoreductase-Inhibitor Complex.
Angew Chem Int Ed Engl
; 59(31): 12669-12673, 2020 07 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-32239740
5.
Inhibitor-Induced Dimerization of an Essential Oxidoreductase from African Trypanosomes.
Angew Chem Int Ed Engl
; 58(11): 3640-3644, 2019 03 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30605929
6.
Fingolimod targeting protein phosphatase 2A differently affects IL-33 induced IL-2 and IFN-γ production in CD8(+) lymphocytes.
Eur J Immunol
; 46(4): 941-51, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26683421
7.
Development of novel dipeptide nitriles as inhibitors of rhodesain of Trypanosoma brucei rhodesiense.
Eur J Med Chem
; 236: 114328, 2022 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35385806
8.
New peptidomimetic rhodesain inhibitors with improved selectivity towards human cathepsins.
Eur J Med Chem
; 238: 114460, 2022 Aug 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35597010
9.
Development of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain.
ACS Med Chem Lett
; 13(7): 1083-1090, 2022 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35859868
10.
Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies.
J Med Chem
; 64(16): 12322-12358, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34378914
11.
Peptidyl Vinyl Ketone Irreversible Inhibitors of Rhodesain: Modifications of the P2 Fragment.
ChemMedChem
; 15(16): 1552-1561, 2020 08 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-32567172
12.
Optimization Strategy of Novel Peptide-Based Michael Acceptors for the Treatment of Human African Trypanosomiasis.
J Med Chem
; 62(23): 10617-10629, 2019 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31714776
13.
Cis autocatalytic cleavage of glycine-linked Zika virus NS2B-NS3 protease constructs.
FEBS Lett
; 593(16): 2204-2213, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31240714
14.
Structure of the Human TRPML2 Ion Channel Extracytosolic/Lumenal Domain.
Structure
; 27(8): 1246-1257.e5, 2019 08 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31178222
15.
Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate.
Cancer Res
; 65(14): 6321-9, 2005 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16024634
16.
Backbone NMR assignments of tryparedoxin, the central protein in the hydroperoxide detoxification cascade of African trypanosomes, in the oxidized and reduced form.
Biomol NMR Assign
; 11(2): 193-196, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28573456
17.
Crosstalk between angiotensin and the nonamyloidogenic pathway of Alzheimer's amyloid precursor protein.
FEBS J
; 284(5): 742-753, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28102934
18.
Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).
J Med Chem
; 60(16): 6911-6923, 2017 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-28763614
19.
Electrochemical Reduction of Carbon Dioxide to Methanol by Direct Injection of Electrons into Immobilized Enzymes on a Modified Electrode.
ChemSusChem
; 9(6): 631-5, 2016 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26890322