Detalhe da pesquisa
1.
GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice.
J Biol Chem
; 297(2): 100928, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34274316
2.
Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome.
Bioorg Med Chem Lett
; 29(12): 1454-1458, 2019 06 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31005442
3.
Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome.
Bioorg Med Chem Lett
; 29(6): 821-825, 2019 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30691925
4.
Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors.
Bioorg Med Chem Lett
; 29(20): 126675, 2019 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31521475
5.
The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.
Bioorg Med Chem Lett
; 27(9): 2023-2028, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28336141
6.
Corrigendum to 'Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors' [Bioorg. Med. Chem. Lett. 29 (2019) 126675].
Bioorg Med Chem Lett
; 30(2): 126771, 2020 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31859161
7.
Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A).
Bioorg Med Chem Lett
; 22(8): 2968-72, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22437115
8.
Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
Bioorg Med Chem Lett
; 21(20): 6188-94, 2011 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21903390
9.
A Potent and Selective Kallikrein-5 Inhibitor Delivers High Pharmacological Activity in Skin from Patients with Netherton Syndrome.
J Invest Dermatol
; 141(9): 2272-2279, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-33744298
10.
Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression.
J Med Chem
; 64(16): 12200-12227, 2021 08 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34387088
11.
Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome.
Acta Crystallogr F Struct Biol Commun
; 75(Pt 5): 385-391, 2019 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31045568
12.
Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode.
Bioorg Med Chem Lett
; 18(1): 318-23, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18006306
13.
Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes.
Bioorg Med Chem Lett
; 18(15): 4433-7, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18602262
14.
Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity.
Bioorg Med Chem Lett
; 18(15): 4428-32, 2008 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18614366
15.
Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR.
Bioorg Med Chem Lett
; 18(1): 324-8, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17981461
16.
Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.
J Med Chem
; 60(8): 3383-3404, 2017 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28398044
17.
Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.
Nat Commun
; 8: 15827, 2017 06 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28604669
18.
The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor.
J Med Chem
; 57(19): 8111-31, 2014 Oct 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-25249180
19.
p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression.
J Med Chem
; 52(20): 6257-69, 2009 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-19772287
20.
Optimization and SAR for dual ErbB-1/ErbB-2 tyrosine kinase inhibition in the 6-furanylquinazoline series.
Bioorg Med Chem Lett
; 16(17): 4686-91, 2006 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16777410