Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation.

Mirchandani, Ananda S; Jenkins, Stephen J; Bain, Calum C; Sanchez-Garcia, Manuel A; Lawson, Hannah; Coelho, Patricia; Murphy, Fiona; Griffith, David M; Zhang, Ailiang; Morrison, Tyler; Ly, Tony; Arienti, Simone; Sadiku, Pranvera; Watts, Emily R; Dickinson, Rebecca S; Reyes, Leila; Cooper, George; Clark, Sarah; Lewis, David; Kelly, Van; Spanos, Christos; Musgrave, Kathryn M; Delaney, Liam; Harper, Isla; Scott, Jonathan; Parkinson, Nicholas J; Rostron, Anthony J; Baillie, J Kenneth; Clohisey, Sara; Pridans, Clare; Campana, Lara; Lewis, Philip Starkey; Simpson, A John; Dockrell, David H; Schwarze, Jürgen; Hirani, Nikhil; Ratcliffe, Peter J; Pugh, Christopher W; Kranc, Kamil; Forbes, Stuart J; Whyte, Moira K B; Walmsley, Sarah R.

Nat Immunol ; 23(6): 927-939, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35624205

2.

Author Correction: Hypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation.

Mirchandani, Ananda S; Jenkins, Stephen J; Bain, Calum C; Sanchez-Garcia, Manuel A; Lawson, Hannah; Coelho, Patricia; Murphy, Fiona; Griffith, David M; Zhang, Ailiang; Morrison, Tyler; Ly, Tony; Arienti, Simone; Sadiku, Pranvera; Watts, Emily R; Dickinson, Rebecca S; Reyes, Leila; Cooper, George; Clark, Sarah; Lewis, David; Kelly, Van; Spanos, Christos; Musgrave, Kathryn M; Delaney, Liam; Harper, Isla; Scott, Jonathan; Parkinson, Nicholas J; Rostron, Anthony J; Baillie, J Kenneth; Clohisey, Sara; Pridans, Clare; Campana, Lara; Lewis, Philip Starkey; Simpson, A John; Dockrell, David H; Schwarze, Jürgen; Hirani, Nikhil; Ratcliffe, Peter J; Pugh, Christopher W; Kranc, Kamil; Forbes, Stuart J; Whyte, Moira K B; Walmsley, Sarah R.

Nat Immunol ; 23(9): 1394, 2022 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-35854097

3.

Getting DAMP(s) Wets the Whistle for Neutrophil Recruitment.

Watts, Emily R; Walmsley, Sarah R.

Immunity ; 48(5): 846-848, 2018 05 15.

Artigo em Inglês | MEDLINE | ID: mdl-29768171

4.

The emerging role for metabolism in fueling neutrophilic inflammation.

Morrison, Tyler; Watts, Emily R; Sadiku, Pranvera; Walmsley, Sarah R.

Immunol Rev ; 314(1): 427-441, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36326284

5.

Neutrophil HIF-1α stabilization is augmented by mitochondrial ROS produced via the glycerol 3-phosphate shuttle.

Willson, Joseph A; Arienti, Simone; Sadiku, Pranvera; Reyes, Leila; Coelho, Patricia; Morrison, Tyler; Rinaldi, Giulia; Dockrell, David H; Whyte, Moira K B; Walmsley, Sarah R.

Blood ; 139(2): 281-286, 2022 01 13.

Artigo em Inglês | MEDLINE | ID: mdl-34411229

6.

NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease.

Ryan, Eilise M; Sadiku, Pranvera; Coelho, Patricia; Watts, Emily R; Zhang, Ailiang; Howden, Andrew J M; Sanchez-Garcia, Manuel A; Bewley, Martin; Cole, Joby; McHugh, Brian J; Vermaelen, Wesley; Ghesquiere, Bart; Carmeliet, Peter; Rodriguez Blanco, Giovanny; Von Kriegsheim, Alex; Sanchez, Yolanda; Rumsey, William; Callahan, James F; Cooper, George; Parkinson, Nicholas; Baillie, Kenneth; Cantrell, Doreen A; McCafferty, John; Choudhury, Gourab; Singh, Dave; Dockrell, David H; Whyte, Moira K B; Walmsley, Sarah R.

Am J Respir Crit Care Med ; 207(8): 998-1011, 2023 04 15.

Artigo em Inglês | MEDLINE | ID: mdl-36724365

7.

Hypoxia and the regulation of myeloid cell metabolic imprinting: consequences for the inflammatory response.

Sadiku, Pranvera; Walmsley, Sarah R.

EMBO Rep ; 20(5)2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30872317

8.

Pressure regulates immune-cell function.

Walmsley, Sarah R.

Nature ; 573(7772): 41-42, 2019 09.

Artigo em Inglês | MEDLINE | ID: mdl-31481766

9.

IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo.

Harris, Alison J; Mirchandani, Ananda S; Lynch, Ruairi W; Murphy, Fiona; Delaney, Liam; Small, Donna; Coelho, Patricia; Watts, Emily R; Sadiku, Pranvera; Griffith, David; Dickinson, Rebecca S; Clark, Eilidh; Willson, Joseph A; Morrison, Tyler; Mazzone, Massimilliano; Carmeliet, Peter; Ghesquiere, Bart; O'Kane, Cecilia; McAuley, Danny; Jenkins, Steve J; Whyte, Moira K B; Walmsley, Sarah R.

Am J Respir Crit Care Med ; 200(2): 235-246, 2019 07 15.

Artigo em Inglês | MEDLINE | ID: mdl-30849228

10.

Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists.

Bewley, Martin A; Budd, Richard C; Ryan, Eilise; Cole, Joby; Collini, Paul; Marshall, Jennifer; Kolsum, Umme; Beech, Gussie; Emes, Richard D; Tcherniaeva, Irina; Berbers, Guy A M; Walmsley, Sarah R; Donaldson, Gavin; Wedzicha, Jadwiga A; Kilty, Iain; Rumsey, William; Sanchez, Yolanda; Brightling, Christopher E; Donnelly, Louise E; Barnes, Peter J; Singh, Dave; Whyte, Moira K B; Dockrell, David H.

Am J Respir Crit Care Med ; 198(6): 739-750, 2018 09 15.

Artigo em Inglês | MEDLINE | ID: mdl-29547002

11.

The role of neutrophils in cancer.

Grecian, Robert; Whyte, Moira K B; Walmsley, Sarah R.

Br Med Bull ; 128(1): 5-14, 2018 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-30137312

12.

Neutrophil energetics and oxygen sensing.

Walmsley, Sarah R; Whyte, Moira K B.

Blood ; 123(18): 2753-4, 2014 May 01.

Artigo em Inglês | MEDLINE | ID: mdl-24786455

13.

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

Thompson, A A Roger; Elks, Philip M; Marriott, Helen M; Eamsamarng, Suttida; Higgins, Kathryn R; Lewis, Amy; Williams, Lynne; Parmar, Selina; Shaw, Gary; McGrath, Emmet E; Formenti, Federico; Van Eeden, Fredericus J; Kinnula, Vuokko L; Pugh, Christopher W; Sabroe, Ian; Dockrell, David H; Chilvers, Edwin R; Robbins, Peter A; Percy, Melanie J; Simon, M Celeste; Johnson, Randall S; Renshaw, Stephen A; Whyte, Moira K B; Walmsley, Sarah R.

Blood ; 123(3): 366-76, 2014 Jan 16.

Artigo em Inglês | MEDLINE | ID: mdl-24196071

14.

Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism.

Elks, Philip M; Brizee, Sabrina; van der Vaart, Michiel; Walmsley, Sarah R; van Eeden, Fredericus J; Renshaw, Stephen A; Meijer, Annemarie H.

PLoS Pathog ; 9(12): e1003789, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-24367256

15.

Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.

Luong, Le A; Fragiadaki, Maria; Smith, Jennifer; Boyle, Joseph; Lutz, Jens; Dean, Jonathan L E; Harten, Sarah; Ashcroft, Margaret; Walmsley, Sarah R; Haskard, Dorian O; Maxwell, Patrick H; Walczak, Henning; Pusey, Charles; Evans, Paul C.

Circ Res ; 112(12): 1583-91, 2013 Jun 07.

Artigo em Inglês | MEDLINE | ID: mdl-23564640

16.

Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis.

Kiss, Judit; Mollenhauer, Martin; Walmsley, Sarah R; Kirchberg, Johanna; Radhakrishnan, Praveen; Niemietz, Thomas; Dudda, Johanna; Steinert, Gunnar; Whyte, Moira K B; Carmeliet, Peter; Mazzone, Massimiliano; Weitz, Jürgen; Schneider, Martin.

J Immunol ; 189(4): 1955-65, 2012 Aug 15.

Artigo em Inglês | MEDLINE | ID: mdl-22786772

17.

Hypoxia, the HIF pathway and neutrophilic inflammatory responses.

Thompson, A A Roger; Binham, John; Plant, Tracie; Whyte, Moira K B; Walmsley, Sarah R.

Biol Chem ; 394(4): 471-7, 2013 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-23324383

18.

Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model.

Elks, Philip M; van Eeden, Fredericus J; Dixon, Giles; Wang, Xingang; Reyes-Aldasoro, Constantino Carlos; Ingham, Philip W; Whyte, Moira K B; Walmsley, Sarah R; Renshaw, Stephen A.

Blood ; 118(3): 712-22, 2011 Jul 21.

Artigo em Inglês | MEDLINE | ID: mdl-21555741

19.

Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression.

Jones, Robert; McDonald, Kate E; Willson, Joseph A; Ghesquière, Bart; Sammut, David; Daniel, Eleni; Harris, Alison J; Lewis, Amy; Thompson, A A Roger; Dickinson, Rebecca S; Plant, Tracie; Murphy, Fiona; Sadiku, Pranvera; Keevil, Brian G; Carmeliet, Peter; Whyte, Moira K B; Newell-Price, John; Walmsley, Sarah R.

Blood ; 127(21): 2641-4, 2016 05 26.

Artigo em Inglês | MEDLINE | ID: mdl-27006389

20.

Hypoxia selectively inhibits respiratory burst activity and killing of Staphylococcus aureus in human neutrophils.

McGovern, Naomi N; Cowburn, Andrew S; Porter, Linsey; Walmsley, Sarah R; Summers, Charlotte; Thompson, Alfred A R; Anwar, Sadia; Willcocks, Lisa C; Whyte, Moira K B; Condliffe, Alison M; Chilvers, Edwin R.

J Immunol ; 186(1): 453-463, 2011 Jan 01.

Artigo em Inglês | MEDLINE | ID: mdl-21135168

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