Detalhe da pesquisa
1.
Seeding, maturation and propagation of amyloid ß-peptide aggregates in Alzheimer's disease.
Brain
; 145(10): 3558-3570, 2022 10 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36270003
2.
Microglia-derived ASC specks cross-seed amyloid-ß in Alzheimer's disease.
Nature
; 552(7685): 355-361, 2017 12 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29293211
3.
Wild-type sTREM2 blocks Aß aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aß aggregation.
J Biol Chem
; 296: 100631, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33823153
4.
Novel potent liposome agonists of triggering receptor expressed on myeloid cells 2 phenocopy antibody treatment in cells.
Glia
; 70(12): 2290-2308, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35912412
5.
A reporter cell system for the triggering receptor expressed on myeloid cells 2 reveals differential effects of disease-associated variants on receptor signaling and activation by antibodies against the stalk region.
Glia
; 69(5): 1126-1139, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33314333
6.
Differential interaction with TREM2 modulates microglial uptake of modified Aß species.
Glia
; 69(12): 2917-2932, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34427354
7.
Carboxy-terminal fragment of amyloid precursor protein mediates lipid droplet accumulation upon γ-secretase inhibition.
Biochem Biophys Res Commun
; 570: 137-142, 2021 09 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34280617
8.
A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2.
Hum Mutat
; 41(1): 169-181, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31464095
9.
The coarse-grained plaque: a divergent Aß plaque-type in early-onset Alzheimer's disease.
Acta Neuropathol
; 140(6): 811-830, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-32926214
10.
TREM2 triggers microglial density and age-related neuronal loss.
Glia
; 67(3): 539-550, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30548312
11.
The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases.
J Biol Chem
; 291(9): 4334-41, 2016 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-26694609
12.
Phosphorylation Interferes with Maturation of Amyloid-ß Fibrillar Structure in the N Terminus.
J Biol Chem
; 291(31): 16059-67, 2016 07 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-27252381
13.
Trehalose Alters Subcellular Trafficking and the Metabolism of the Alzheimer-associated Amyloid Precursor Protein.
J Biol Chem
; 291(20): 10528-40, 2016 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26957541
14.
Intramembranous processing by γ-secretase regulates reverse signaling of ephrin-B2 in migration of microglia.
Glia
; 65(7): 1103-1118, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28370426
15.
γ-Secretase in microglia - implications for neurodegeneration and neuroinflammation.
J Neurochem
; 143(4): 445-454, 2017 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-28940294
16.
Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2).
J Neuroinflammation
; 13: 17, 2016 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-26792193
17.
The intact Kunitz domain protects the amyloid precursor protein from being processed by matriptase-2.
Biol Chem
; 397(8): 777-90, 2016 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27078672
18.
Epigenetic and gene expression changes of neuronal cells from MSA patients are pronounced in enzymes for cell metabolism and calcium-regulated protein kinases.
Acta Neuropathol
; 142(4): 781-783, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34370068
19.
Phosphorylation of the amyloid ß-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity.
Acta Neuropathol
; 131(4): 525-37, 2016 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-26898910
20.
Deficiency of sphingosine-1-phosphate lyase impairs lysosomal metabolism of the amyloid precursor protein.
J Biol Chem
; 289(24): 16761-72, 2014 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24808180