Detalhe da pesquisa
1.
Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.
PLoS Pathog
; 12(8): e1005737, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27500641
2.
A soluble form of the pilus protein FimA targets the VDAC-hexokinase complex at mitochondria to suppress host cell apoptosis.
Mol Cell
; 37(6): 768-83, 2010 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20347420
3.
Discovery of 2-oxopiperazine dengue inhibitors by scaffold morphing of a phenotypic high-throughput screening hit.
Bioorg Med Chem Lett
; 27(6): 1385-1389, 2017 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28216045
4.
Discovery of Dengue Virus NS4B Inhibitors.
J Virol
; 89(16): 8233-44, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26018165
5.
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.
Science
; 380(6652): 1349-1356, 2023 06 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37384702
6.
NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models.
Sci Transl Med
; 13(579)2021 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33536278
7.
TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process.
Exp Cell Res
; 315(7): 1313-25, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19100260
8.
Interaction of kendomycin and semi-synthetic analogues with the anti-apoptotic protein Bcl-xl.
Bioorg Med Chem Lett
; 18(21): 5771-3, 2008 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18845435
9.
Development of a Cytopathic Effect-Based Phenotypic Screening Assay against Cryptosporidium.
ACS Infect Dis
; 4(4): 635-645, 2018 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29341586
10.
Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft.
J Mol Biol
; 364(3): 536-49, 2006 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17011577
11.
The Natural Product Cavinafungin Selectively Interferes with Zika and Dengue Virus Replication by Inhibition of the Host Signal Peptidase.
Cell Rep
; 19(3): 451-460, 2017 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28423309
12.
Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools.
Biochem J
; 391(Pt 1): 25-32, 2005 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-15960610
13.
Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign.
J Biomol Screen
; 20(1): 153-63, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25252731
14.
Identification of covalent active site inhibitors of dengue virus protease.
Drug Des Devel Ther
; 9: 6389-99, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26677315
15.
Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening.
Antiviral Res
; 119: 36-46, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25896272
16.
Lead optimization of spiropyrazolopyridones: a new and potent class of dengue virus inhibitors.
ACS Med Chem Lett
; 6(3): 344-8, 2015 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25878766
17.
Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1.
J Med Chem
; 53(5): 2314-8, 2010 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20158203
18.
Differential scanning fluorimetry as secondary screening platform for small molecule inhibitors of Bcl-XL.
Cell Cycle
; 8(23): 3943-52, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19901550
19.
Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism.
J Biol Chem
; 283(13): 8423-33, 2008 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-18230621
20.
Structure-activity relationship studies of phenanthridine-based Bcl-XL inhibitors.
J Med Chem
; 51(21): 6699-710, 2008 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18925736