Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization.

Park, Joo Min; Hu, Jia-Hua; Milshteyn, Aleksandr; Zhang, Ping-Wu; Moore, Chester G; Park, Sungjin; Datko, Michael C; Domingo, Racquel D; Reyes, Cindy M; Wang, Xiaodong J; Etzkorn, Felicia A; Xiao, Bo; Szumlinski, Karen K; Kern, Dorothee; Linden, David J; Worley, Paul F.

Cell ; 154(3): 637-50, 2013 Aug 01.

Artigo em Inglês | MEDLINE | ID: mdl-23911326

2.

Stereospecific gating of functional motions in Pin1.

Namanja, Andrew T; Wang, Xiaodong J; Xu, Bailing; Mercedes-Camacho, Ana Y; Wilson, Kimberly A; Etzkorn, Felicia A; Peng, Jeffrey W.

Proc Natl Acad Sci U S A ; 108(30): 12289-94, 2011 Jul 26.

Artigo em Inglês | MEDLINE | ID: mdl-21746900

3.

Toward flexibility-activity relationships by NMR spectroscopy: dynamics of Pin1 ligands.

Namanja, Andrew T; Wang, Xiaodong J; Xu, Bailing; Mercedes-Camacho, Ana Y; Wilson, Brian D; Wilson, Kimberly A; Etzkorn, Felicia A; Peng, Jeffrey W.

J Am Chem Soc ; 132(16): 5607-9, 2010 Apr 28.

Artigo em Inglês | MEDLINE | ID: mdl-20356313

4.

Potent activity of a PK/PBAN analog with an (E)-alkene, trans-Pro mimic identifies the Pro orientation and core conformation during interaction with HevPBANR-C receptor.

Nachman, Ronald J; Kim, Young-Joon; Wang, Xiaodong J; Etzkorn, Felicia A; Kaczmarek, Krzysztof; Zabrocki, Janusz; Adams, Michael E.

Bioorg Med Chem ; 17(12): 4216-20, 2009 Jun 15.

Artigo em Inglês | MEDLINE | ID: mdl-19356938

5.

The effect of a trans-locked Gly-Pro alkene isostere on collagen triple helix stability.

Dai, Nan; Wang, Xiaodong J; Etzkorn, Felicia A.

J Am Chem Soc ; 130(16): 5396-7, 2008 Apr 23.

Artigo em Inglês | MEDLINE | ID: mdl-18366169

6.

Evaluation of insect CAP2b analogs with either an (E)-alkene, trans- or a (Z)-alkene, cis-Pro isostere identifies the Pro orientation for antidiuretic activity in the stink bug.

Nachman, Ronald J; Wang, Xiaodong J; Etzkorn, Felicia A; Kaczmarek, Krzysztof; Zabrocki, Janusz; Lopez, Juan; Coast, Geoffrey M.

Peptides ; 41: 101-6, 2013 Mar.

Artigo em Inglês | MEDLINE | ID: mdl-23036324

7.

Structural and kinetic analysis of prolyl-isomerization/phosphorylation cross-talk in the CTD code.

Zhang, Mengmeng; Wang, Xiaodong J; Chen, Xi; Bowman, Marianne E; Luo, Yonghua; Noel, Joseph P; Ellington, Andrew D; Etzkorn, Felicia A; Zhang, Yan.

ACS Chem Biol ; 7(8): 1462-70, 2012 Aug 17.

Artigo em Inglês | MEDLINE | ID: mdl-22670809

8.

Evaluation of a PK/PBAN analog with an (E)-alkene, trans-Pro isostere identifies the Pro orientation for activity in four diverse PK/PBAN bioassays.

Nachman, Ronald J; Wang, Xiaodong J; Etzkorn, Felicia A; Aziz, Orna Ben; Davidovitch, Michael; Kaczmarek, Krzysztof; Zabrocki, Janusz; Strey, Allison; Pryor, Nan; Altstein, Miriam.

Peptides ; 30(7): 1254-9, 2009 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-19416747

9.

Peptidyl-prolyl isomerase inhibitors.

Wang, Xiaodong J; Etzkorn, Felicia A.

Biopolymers ; 84(2): 125-46, 2006.

Artigo em Inglês | MEDLINE | ID: mdl-16302169

10.

Conformationally locked isostere of phosphoSer-cis-Pro inhibits Pin1 23-fold better than phosphoSer-trans-Pro isostere.

Wang, Xiaodong J; Xu, Bailing; Mullins, Ashley B; Neiler, Freda K; Etzkorn, Felicia A.

J Am Chem Soc ; 126(47): 15533-42, 2004 Dec 01.

Artigo em Inglês | MEDLINE | ID: mdl-15563182

11.

Serine-cis-proline and serine-trans-proline isosteres: stereoselective synthesis of (Z)- and (E)-alkene mimics by Still-Wittig and Ireland-Claisen rearrangements.

Wang, Xiaodong J; Hart, Scott A; Xu, Bailing; Mason, Matthew D; Goodell, John R; Etzkorn, Felicia A.

J Org Chem ; 68(6): 2343-9, 2003 Mar 21.

Artigo em Inglês | MEDLINE | ID: mdl-12636401

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