Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Identification of Reduced ERAP2 Expression and a Novel HLA Allele as Components of a Risk Score for Susceptibility to Liver Injury Due to Amoxicillin-Clavulanate.

Nicoletti, Paola; Dellinger, Andrew; Li, Yi Ju; Barnhart, Huiman X; Chalasani, Naga; Fontana, Robert J; Odin, Joseph A; Serrano, Jose; Stolz, Andrew; Etheridge, Amy S; Innocenti, Federico; Govaere, Olivier; Grove, Jane I; Stephens, Camilla; Aithal, Guruprasad P; Andrade, Raul J; Bjornsson, Einar S; Daly, Ann K; Lucena, M Isabel; Watkins, Paul B.

Gastroenterology ; 164(3): 454-466, 2023 03.

Artigo em Inglês | MEDLINE | ID: mdl-36496055

2.

ERAP-1 and ERAP-2 Variants in Liver Injury After COVID-19 mRNA Vaccination: A US Multicenter Study.

Fontana, Robert J; Li, Yi Ju; Vuppalanchi, Raj; Kleiner, David E; Gu, Jiezhun; Shroff, Hersh; Van Wagner, Lisa B; Watkins, Paul B.

Am J Gastroenterol ; 2024 Mar 25.

Artigo em Inglês | MEDLINE | ID: mdl-38314748

3.

Human Leukocyte Antigen B14:01 and B35:01 Are Associated With Trimethoprim-Sulfamethoxazole Induced Liver Injury.

Li, Yi-Ju; Phillips, Elizabeth J; Dellinger, Andrew; Nicoletti, Paola; Schutte, Ryan; Li, Danmeng; Ostrov, David A; Fontana, Robert J; Watkins, Paul B; Stolz, Andrew; Daly, Ann K; Aithal, Guruprasad P; Barnhart, Huiman; Chalasani, Naga.

Hepatology ; 73(1): 268-281, 2021 01.

Artigo em Inglês | MEDLINE | ID: mdl-32270503

4.

Incidence and Etiology of Drug-Induced Liver Injury in Mainland China.

Shen, Tao; Liu, Yingxia; Shang, Jia; Xie, Qing; Li, Jun; Yan, Ming; Xu, Jianming; Niu, Junqi; Liu, Jiajun; Watkins, Paul B; Aithal, Guruprasad P; Andrade, Raúl J; Dou, Xiaoguang; Yao, Lvfeng; Lv, Fangfang; Wang, Qi; Li, Yongguo; Zhou, Xinmin; Zhang, Yuexin; Zong, Peilan; Wan, Bin; Zou, Zhengsheng; Yang, Dongliang; Nie, Yuqiang; Li, Dongliang; Wang, Yuya; Han, Xi'an; Zhuang, Hui; Mao, Yimin; Chen, Chengwei.

Gastroenterology ; 156(8): 2230-2241.e11, 2019 06.

Artigo em Inglês | MEDLINE | ID: mdl-30742832

5.

A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury.

Cirulli, Elizabeth T; Nicoletti, Paola; Abramson, Karen; Andrade, Raul J; Bjornsson, Einar S; Chalasani, Naga; Fontana, Robert J; Hallberg, Pär; Li, Yi Ju; Lucena, M Isabel; Long, Nanye; Molokhia, Mariam; Nelson, Matthew R; Odin, Joseph A; Pirmohamed, Munir; Rafnar, Thorunn; Serrano, Jose; Stefánsson, Kári; Stolz, Andrew; Daly, Ann K; Aithal, Guruprasad P; Watkins, Paul B.

Gastroenterology ; 156(6): 1707-1716.e2, 2019 05.

Artigo em Inglês | MEDLINE | ID: mdl-30664875

6.

HLA associations with infliximab-induced liver injury.

Bruno, Christopher D; Fremd, Brandon; Church, Rachel J; Daly, Ann K; Aithal, Guruprasad P; Björnsson, Einar S; Larrey, Dominique; Watkins, Paul B; Chow, Christina R.

Pharmacogenomics J ; 20(5): 681-686, 2020 10.

Artigo em Inglês | MEDLINE | ID: mdl-32024945

7.

Best practices for detection, assessment and management of suspected immune-mediated liver injury caused by immune checkpoint inhibitors during drug development.

Regev, Arie; Avigan, Mark I; Kiazand, Alexandre; Vierling, John M; Lewis, James H; Omokaro, Stephanie O; Di Bisceglie, Adrian M; Fontana, Robert J; Bonkovsky, Herbert L; Freston, James W; Uetrecht, Jack P; Miller, Ethan D; Pehlivanov, Nonko D; Haque, Syed Asif; Harrison, Melanie J; Kullak-Ublick, Gerd A; Li, Hewei; Patel, Niti N; Patwardhan, Meenal; Price, Karen D; Watkins, Paul B; Chalasani, Naga P.

J Autoimmun ; 114: 102514, 2020 11.

Artigo em Inglês | MEDLINE | ID: mdl-32768244

8.

Candidate biomarkers for the diagnosis and prognosis of drug-induced liver injury: An international collaborative effort.

Church, Rachel J; Kullak-Ublick, Gerd A; Aubrecht, Jiri; Bonkovsky, Herbert L; Chalasani, Naga; Fontana, Robert J; Goepfert, Jens C; Hackman, Frances; King, Nicholas M P; Kirby, Simon; Kirby, Patrick; Marcinak, John; Ormarsdottir, Sif; Schomaker, Shelli J; Schuppe-Koistinen, Ina; Wolenski, Francis; Arber, Nadir; Merz, Michael; Sauer, John-Michael; Andrade, Raul J; van Bömmel, Florian; Poynard, Thierry; Watkins, Paul B.

Hepatology ; 69(2): 760-773, 2019 02.

Artigo em Inglês | MEDLINE | ID: mdl-29357190

9.

Safety and tolerability of ubrogepant following intermittent, high-frequency dosing: Randomized, placebo-controlled trial in healthy adults.

Goadsby, Peter J; Tepper, Stewart J; Watkins, Paul B; Ayele, Girma; Miceli, Rosa; Butler, Matthew; Severt, Lawrence; Finnegan, Michelle; Szegedi, Armin; Trugman, Joel M; Jakate, Abhijeet.

Cephalalgia ; 39(14): 1753-1761, 2019 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-31537107

10.

Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling.

Woodhead, Jeffrey L; Yang, Kyunghee; Oldach, David; MacLauchlin, Chris; Fernandes, Prabhavathi; Watkins, Paul B; Siler, Scott Q; Howell, Brett A.

Pharm Res ; 36(3): 48, 2019 Feb 07.

Artigo em Inglês | MEDLINE | ID: mdl-30734107

11.

Determination of fasiglifam-induced liver toxicity: Insights from the data monitoring committee of the fasiglifam clinical trials program.

Shavadia, Jay S; Sharma, Abhinav; Gu, Xiangqiong; Neaton, James; DeLeve, Laurie; Holmes, David; Home, Phillip; Eckel, Robert H; Watkins, Paul B; Granger, Christopher B.

Clin Trials ; 16(3): 253-262, 2019 06.

Artigo em Inglês | MEDLINE | ID: mdl-30880443

12.

Association of Liver Injury From Specific Drugs, or Groups of Drugs, With Polymorphisms in HLA and Other Genes in a Genome-Wide Association Study.

Nicoletti, Paola; Aithal, Guruprasad P; Bjornsson, Einar S; Andrade, Raul J; Sawle, Ashley; Arrese, Marco; Barnhart, Huiman X; Bondon-Guitton, Emmanuelle; Hayashi, Paul H; Bessone, Fernando; Carvajal, Alfonso; Cascorbi, Ingolf; Cirulli, Elizabeth T; Chalasani, Naga; Conforti, Anita; Coulthard, Sally A; Daly, Mark J; Day, Christopher P; Dillon, John F; Fontana, Robert J; Grove, Jane I; Hallberg, Pär; Hernández, Nelia; Ibáñez, Luisa; Kullak-Ublick, Gerd A; Laitinen, Tarja; Larrey, Dominique; Lucena, M Isabel; Maitland-van der Zee, Anke H; Martin, Jennifer H; Molokhia, Mariam; Pirmohamed, Munir; Powell, Elizabeth E; Qin, Shengying; Serrano, Jose; Stephens, Camilla; Stolz, Andrew; Wadelius, Mia; Watkins, Paul B; Floratos, Aris; Shen, Yufeng; Nelson, Matthew R; Urban, Thomas J; Daly, Ann K.

Gastroenterology ; 152(5): 1078-1089, 2017 04.

Artigo em Inglês | MEDLINE | ID: mdl-28043905

13.

John R. Senior, MD.

Avigan, Mark; Watkins, Paul B.

Hepatology ; 75(5): 1354-1355, 2022 05.

Artigo em Inglês | MEDLINE | ID: mdl-35194822

14.

Moving the Needle to Reduce Acetaminophen (Paracetamol) Hepatotoxicity.

Ghany, Marc G; Watkins, Paul B.

JAMA ; 329(9): 713-715, 2023 03 07.

Artigo em Inglês | MEDLINE | ID: mdl-36881043

15.

The transformation in biomarker detection and management of drug-induced liver injury.

Church, Rachel J; Watkins, Paul B.

Liver Int ; 37(11): 1582-1590, 2017 11.

Artigo em Inglês | MEDLINE | ID: mdl-28386997

16.

Profiles of miRNAs in serum in severe acute drug induced liver injury and their prognostic significance.

Russo, Mark W; Steuerwald, Nury; Norton, Harry J; Anderson, William E; Foureau, David; Chalasani, Naga; Fontana, Robert J; Watkins, Paul B; Serrano, Jose; Bonkovsky, Herbert L.

Liver Int ; 37(5): 757-764, 2017 05.

Artigo em Inglês | MEDLINE | ID: mdl-27860186

17.

Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury.

Mikus, Maria; Drobin, Kimi; Gry, Marcus; Bachmann, Julie; Lindberg, Johan; Yimer, Getnet; Aklillu, Eleni; Makonnen, Eyasu; Aderaye, Getachew; Roach, James; Fier, Ian; Kampf, Caroline; Göpfert, Jens; Perazzo, Hugo; Poynard, Thierry; Stephens, Camilla; Andrade, Raúl J; Lucena, M Isabel; Arber, Nadir; Uhlén, Mathias; Watkins, Paul B; Schwenk, Jochen M; Nilsson, Peter; Schuppe-Koistinen, Ina.

Liver Int ; 37(1): 132-140, 2017 01.

Artigo em Inglês | MEDLINE | ID: mdl-27224670

18.

Features and Outcomes of 899 Patients With Drug-Induced Liver Injury: The DILIN Prospective Study.

Chalasani, Naga; Bonkovsky, Herbert L; Fontana, Robert; Lee, William; Stolz, Andrew; Talwalkar, Jayant; Reddy, K Rajendar; Watkins, Paul B; Navarro, Victor; Barnhart, Huiman; Gu, Jiezhun; Serrano, Jose.

Gastroenterology ; 148(7): 1340-52.e7, 2015 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-25754159

19.

Idiosyncratic drug-induced liver injury is associated with substantial morbidity and mortality within 6 months from onset.

Fontana, Robert J; Hayashi, Paul H; Gu, Jiezhun; Reddy, K Rajender; Barnhart, Huiman; Watkins, Paul B; Serrano, Jose; Lee, William M; Chalasani, Naga; Stolz, Andrew; Davern, Timothy; Talwakar, Jayant A.

Gastroenterology ; 147(1): 96-108.e4, 2014 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-24681128

20.

Persistent liver biochemistry abnormalities are more common in older patients and those with cholestatic drug induced liver injury.

Fontana, Robert J; Hayashi, Paul H; Barnhart, Huiman; Kleiner, David E; Reddy, K Rajender; Chalasani, Naga; Lee, William M; Stolz, Andrew; Phillips, Thomas; Serrano, Jose; Watkins, Paul B.

Am J Gastroenterol ; 110(10): 1450-9, 2015 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-26346867

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