Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Targeting myeloid chemotaxis to reverse prostate cancer therapy resistance.

Guo, Christina; Sharp, Adam; Gurel, Bora; Crespo, Mateus; Figueiredo, Ines; Jain, Suneil; Vogl, Ursula; Rekowski, Jan; Rouhifard, Mahtab; Gallagher, Lewis; Yuan, Wei; Carreira, Suzanne; Chandran, Khobe; Paschalis, Alec; Colombo, Ilaria; Stathis, Anastasios; Bertan, Claudia; Seed, George; Goodall, Jane; Raynaud, Florence; Ruddle, Ruth; Swales, Karen E; Malia, Jason; Bogdan, Denisa; Tiu, Crescens; Caldwell, Reece; Aversa, Caterina; Ferreira, Ana; Neeb, Antje; Tunariu, Nina; Westaby, Daniel; Carmichael, Juliet; Fenor de la Maza, Maria Dolores; Yap, Christina; Matthews, Ruth; Badham, Hannah; Prout, Toby; Turner, Alison; Parmar, Mona; Tovey, Holly; Riisnaes, Ruth; Flohr, Penny; Gil, Jesus; Waugh, David; Decordova, Shaun; Schlag, Anna; Calì, Bianca; Alimonti, Andrea; de Bono, Johann S.

Nature ; 623(7989): 1053-1061, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-37844613

2.

P1' specificity of the S219V/R203G mutant tobacco etch virus protease.

Golda, Mária; Hoffka, Gyula; Cherry, Scott; Tropea, Joseph E; Lountos, George T; Waugh, David S; Wlodawer, Alexander; Tozsér, József; Mótyán, János András.

Proteins ; 2024 Apr 26.

Artigo em Inglês | MEDLINE | ID: mdl-38666764

3.

A really big fossil whale.

Thewissen, J G M; Waugh, David A.

Nature ; 620(7975): 734-735, 2023 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-37532853

4.

Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer.

Mak, Blossom; Lin, Hui-Ming; Kwan, Edmond M; Fettke, Heidi; Tran, Ben; Davis, Ian D; Mahon, Kate; Stockler, Martin R; Briscoe, Karen; Marx, Gavin; Zhang, Alison; Crumbaker, Megan; Tan, Winston; Huynh, Kevin; Meikle, Thomas G; Mellett, Natalie A; Hoy, Andrew J; Du, Pan; Yu, Jianjun; Jia, Shidong; Joshua, Anthony M; Waugh, David J; Butler, Lisa M; Kohli, Manish; Meikle, Peter J; Azad, Arun A; Horvath, Lisa G.

BMC Med ; 20(1): 112, 2022 03 25.

Artigo em Inglês | MEDLINE | ID: mdl-35331214

5.

RNase III: Genetics and function; structure and mechanism.

Court, Donald L; Gan, Jianhua; Liang, Yu-He; Shaw, Gary X; Tropea, Joseph E; Costantino, Nina; Waugh, David S; Ji, Xinhua.

Annu Rev Genet ; 47: 405-31, 2013.

Artigo em Inglês | MEDLINE | ID: mdl-24274754

6.

The molecular mechanism of dsRNA processing by a bacterial Dicer.

Jin, Lan; Song, He; Tropea, Joseph E; Needle, Danielle; Waugh, David S; Gu, Shuo; Ji, Xinhua.

Nucleic Acids Res ; 47(9): 4707-4720, 2019 05 21.

Artigo em Inglês | MEDLINE | ID: mdl-30916338

7.

Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening.

Lountos, George T; Zhao, Xue Zhi; Kiselev, Evgeny; Tropea, Joseph E; Needle, Danielle; Pommier, Yves; Burke, Terrence R; Waugh, David S.

Nucleic Acids Res ; 47(19): 10134-10150, 2019 11 04.

Artigo em Inglês | MEDLINE | ID: mdl-31199869

8.

Specificity Studies of the Venezuelan Equine Encephalitis Virus Non-Structural Protein 2 Protease Using Recombinant Fluorescent Substrates.

Bozóki, Beáta; Mótyán, János András; Hoffka, Gyula; Waugh, David S; Tozsér, József.

Int J Mol Sci ; 21(20)2020 Oct 16.

Artigo em Inglês | MEDLINE | ID: mdl-33081394

9.

A new zygodactylid species indicates the persistence of stem passerines into the early Oligocene in North America.

Hieronymus, Tobin L; Waugh, David A; Clarke, Julia A.

BMC Evol Biol ; 19(1): 3, 2019 01 05.

Artigo em Inglês | MEDLINE | ID: mdl-30611195

10.

On the Droplet Size and Application of Wettability Analysis for the Development of Ink and Printing Substrates.

Grüßer, Martin; Waugh, David G; Lawrence, Jonathan; Langer, Nils; Scholz, Daniel.

Langmuir ; 35(38): 12356-12365, 2019 Sep 24.

Artigo em Inglês | MEDLINE | ID: mdl-31468975

11.

A dual protease approach for expression and affinity purification of recombinant proteins.

Raran-Kurussi, Sreejith; Waugh, David S.

Anal Biochem ; 504: 30-7, 2016 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-27105777

12.

The remarkable solubility-enhancing power of Escherichia coli maltose-binding protein.

Waugh, David S.

Postepy Biochem ; 62(3): 377-382, 2016.

Artigo em Inglês | MEDLINE | ID: mdl-28132493

13.

Insights Into the Allosteric Inhibition of the SUMO E2 Enzyme Ubc9.

Hewitt, William M; Lountos, George T; Zlotkowski, Katherine; Dahlhauser, Samuel D; Saunders, Lindsey B; Needle, Danielle; Tropea, Joseph E; Zhan, Chendi; Wei, Guanghong; Ma, Buyong; Nussinov, Ruth; Waugh, David S; Schneekloth, John S.

Angew Chem Int Ed Engl ; 55(19): 5703-7, 2016 05 04.

Artigo em Inglês | MEDLINE | ID: mdl-27038327

14.

Structures of the Middle East respiratory syndrome coronavirus 3C-like protease reveal insights into substrate specificity.

Needle, Danielle; Lountos, George T; Waugh, David S.

Acta Crystallogr D Biol Crystallogr ; 71(Pt 5): 1102-11, 2015 May.

Artigo em Inglês | MEDLINE | ID: mdl-25945576

15.

Positional effects of fusion partners on the yield and solubility of MBP fusion proteins.

Raran-Kurussi, Sreejith; Keefe, Karina; Waugh, David S.

Protein Expr Purif ; 110: 159-64, 2015 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-25782741

16.

Ex vivo expansion of human outgrowth endothelial cells leads to IL-8-mediated replicative senescence and impaired vasoreparative function.

Medina, Reinhold J; O'Neill, Christina L; O'Doherty, T Michelle; Chambers, Sarah E J; Guduric-Fuchs, Jasenka; Neisen, Jessica; Waugh, David J; Simpson, David A; Stitt, Alan W.

Stem Cells ; 31(8): 1657-68, 2013 Aug.

Artigo em Inglês | MEDLINE | ID: mdl-23629812

17.

Unrelated solubility-enhancing fusion partners MBP and NusA utilize a similar mode of action.

Raran-Kurussi, Sreejith; Waugh, David S.

Biotechnol Bioeng ; 111(12): 2407-11, 2014 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-24942647

18.

The Era GTPase recognizes the GAUCACCUCC sequence and binds helix 45 near the 3' end of 16S rRNA.

Tu, Chao; Zhou, Xiaomei; Tarasov, Sergey G; Tropea, Joseph E; Austin, Brian P; Waugh, David S; Court, Donald L; Ji, Xinhua.

Proc Natl Acad Sci U S A ; 108(25): 10156-61, 2011 Jun 21.

Artigo em Inglês | MEDLINE | ID: mdl-21646538

19.

Androgen deprivation results in time-dependent hypoxia in LNCaP prostate tumours: informed scheduling of the bioreductive drug AQ4N improves treatment response.

Ming, Louise; Byrne, Niall M; Camac, Sarah Nicole; Mitchell, Christopher A; Ward, Claire; Waugh, David J; McKeown, Stephanie R; Worthington, Jenny.

Int J Cancer ; 132(6): 1323-32, 2013 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-22915157

20.

Differential temperature dependence of tobacco etch virus and rhinovirus 3C proteases.

Raran-Kurussi, Sreejith; Tözsér, József; Cherry, Scott; Tropea, Joseph E; Waugh, David S.

Anal Biochem ; 436(2): 142-4, 2013 May 15.

Artigo em Inglês | MEDLINE | ID: mdl-23395976

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