Detalhe da pesquisa
1.
The human hepatocyte TXG-MAPr: gene co-expression network modules to support mechanism-based risk assessment.
Arch Toxicol
; 95(12): 3745-3775, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34626214
2.
Structure-guided expansion of kinase fragment libraries driven by support vector machine models.
Biochim Biophys Acta
; 1804(3): 642-52, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20005305
3.
Leveraging health social networking communities in translational research.
J Biomed Inform
; 44(4): 536-44, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21284958
4.
A pan-cancer transcriptome analysis identifies replication fork and innate immunity genes as modifiers of response to the CHK1 inhibitor prexasertib.
Oncotarget
; 11(3): 216-236, 2020 Jan 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32076484
5.
GPU accelerated support vector machines for mining high-throughput screening data.
J Chem Inf Model
; 49(12): 2718-25, 2009 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19961205
6.
A Novel Open Access Web Portal for Integrating Mechanistic and Toxicogenomic Study Results.
Toxicol Sci
; 170(2): 296-309, 2019 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31020328
7.
Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy.
Mol Cancer Ther
; 18(12): 2207-2219, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31530649
8.
Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene.
Cancer Discov
; 9(2): 248-263, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30373917
9.
Abemaciclib Is Active in Preclinical Models of Ewing Sarcoma via Multipronged Regulation of Cell Cycle, DNA Methylation, and Interferon Pathway Signaling.
Clin Cancer Res
; 24(23): 6028-6039, 2018 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30131386
10.
Mouse PDX Trial Suggests Synergy of Concurrent Inhibition of RAF and EGFR in Colorectal Cancer with BRAF or KRAS Mutations.
Clin Cancer Res
; 23(18): 5547-5560, 2017 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28611205
11.
Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib.
Cancer Cell
; 32(6): 761-776.e6, 2017 Dec 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29232554
12.
Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers.
Cancer Cell
; 28(3): 384-98, 2015 Sep 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26343583
13.
The role of translational bioinformatics in drug discovery.
Drug Discov Today
; 16(9-10): 426-34, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21402166
14.
Kinase inhibitor data modeling and de novo inhibitor design with fragment approaches.
J Med Chem
; 52(20): 6456-66, 2009 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-19791746