Detalhe da pesquisa
1.
Integrated Direct-to-Biology Platform for the Nanoscale Synthesis and Biological Evaluation of PROTACs.
J Med Chem
; 66(22): 15437-15452, 2023 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37933562
2.
Identification and Optimization of a Ligand-Efficient Benzoazepinone Bromodomain and Extra Terminal (BET) Family Acetyl-Lysine Mimetic into the Oral Candidate Quality Molecule I-BET432.
J Med Chem
; 65(22): 15174-15207, 2022 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36378954
3.
Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.
J Med Chem
; 65(1): 633-664, 2022 01 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-34928601
4.
Discovery of a potent series of non-steroidal non α-trifluoromethyl carbinol glucocorticoid receptor agonists with reduced lipophilicity.
Bioorg Med Chem Lett
; 21(4): 1126-33, 2011 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21257309
5.
Discovery of a Bromodomain and Extraterminal Inhibitor with a Low Predicted Human Dose through Synergistic Use of Encoded Library Technology and Fragment Screening.
J Med Chem
; 63(2): 714-746, 2020 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31904959
6.
Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
J Med Chem
; 62(10): 5096-5110, 2019 05 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31013427
7.
Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3-Kinase δ through a Deconstruction and Regrowth Approach.
J Med Chem
; 61(24): 11061-11073, 2018 12 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-30532965
8.
Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease.
J Med Chem
; 59(15): 7239-51, 2016 08 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27429068
9.
A practical drug discovery project at the undergraduate level.
Drug Discov Today
; 18(23-24): 1158-72, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24051399
10.
Synthesis of arrays using low molecular weight MPEG-assisted Mitsunobu reaction.
ACS Comb Sci
; 13(3): 280-5, 2011 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-21438502
11.
Correction to Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease.
J Med Chem
; 59(20): 9574, 2016 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27726364
12.
Correction to Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease.
J Med Chem
; 59(17): 8148, 2016 09 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27548024