1.
Eur J Med Chem
; 40(6): 529-41, 2005 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15922837
RESUMO
A series of combretastatins substituted with epoxides, amides and small alkyl groups has been synthesised and evaluated for cytotoxicity and their ability to inhibit the assembly of tubulin. The methyl and ethyl substituted phenols 36, 44 have shown potent antimitotic effects whilst exhibiting reduced cytotoxicity.