Detalhe da pesquisa
1.
Safety, Tolerability, and Pharmacokinetics of Single- and Multiple-Ascending Doses of Sunobinop in Healthy Participants.
Clin Pharmacol Drug Dev
; 2024 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38476082
2.
The nociceptin/orphanin FQ receptor partial agonist sunobinop promotes non-REM sleep in rodents and patients with insomnia.
J Clin Invest
; 134(1)2024 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37883189
3.
Particulate levodopa nose-to-brain delivery targets dopamine to the brain with no plasma exposure.
Int J Pharm
; 618: 121658, 2022 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-35292396
4.
Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice.
J Neurosci
; 30(6): 2017-24, 2010 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-20147530
5.
Genetic and functional analysis of human P2X5 reveals a distinct pattern of exon 10 polymorphism with predominant expression of the nonfunctional receptor isoform.
Mol Pharmacol
; 77(6): 953-60, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20223879
6.
Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system.
Mol Pharmacol
; 78(6): 996-1003, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20855465
7.
Depression-like phenotype following chronic CB1 receptor antagonism.
Neurobiol Dis
; 39(2): 148-55, 2010 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-20381618
8.
Tri-partite complex for axonal transport drug delivery achieves pharmacological effect.
BMC Neurosci
; 11: 8, 2010 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-20085661
9.
Structure-activity relationships of norepinephrine reuptake inhibitors with benzothiadiazine dioxide or dihydrosulfostyril cores.
Bioorg Med Chem Lett
; 20(5): 1555-8, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20153188
10.
Pharmacological evaluation of NSAID-induced gastropathy as a "Translatable" model of referred visceral hypersensitivity.
World J Gastroenterol
; 23(33): 6065-6076, 2017 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28970722
11.
Neuropathy-induced osteopenia in rats is not due to a reduction in weight born on the affected limb.
Bone
; 38(3): 387-93, 2006 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-16203196
12.
Preclinical Pharmacological Approaches in Drug Discovery for Chronic Pain.
Adv Pharmacol
; 75: 303-23, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26920017
13.
Robustness of arterial blood gas analysis for assessment of respiratory safety pharmacology in rats.
J Pharmacol Toxicol Methods
; 78: 32-41, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26589431
14.
A randomized, double-blind, positive-controlled, 3-way cross-over human experimental pain study of a TRPV1 antagonist (V116517) in healthy volunteers and comparison with preclinical profile.
Pain
; 157(9): 2057-2067, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27168361
15.
Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy.
Neuropharmacology
; 48(5): 658-72, 2005 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-15814101
16.
A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833.
Eur J Pharmacol
; 528(1-3): 65-72, 2005 Dec 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-16316650
17.
Pharmacological characterisation of a rat model of incisional pain.
Br J Pharmacol
; 141(1): 85-91, 2004 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-14597606
18.
A-317491, a selective P2X3/P2X2/3 receptor antagonist, reverses inflammatory mechanical hyperalgesia through action at peripheral receptors in rats.
Eur J Pharmacol
; 504(1-2): 45-53, 2004 Nov 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-15507220
19.
An industry perspective on the role and utility of animal models of pain in drug discovery.
Neurosci Lett
; 557 Pt A: 65-72, 2013 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-23994390
20.
Inflammatory cytokine and chemokine expression is differentially modulated acutely in the dorsal root ganglion in response to different nerve root compressions.
Spine (Phila Pa 1976)
; 36(3): 197-202, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20714281