Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Crossing unlikely paths in science.

Whye, Dosh.

J Cell Sci ; 135(9)2022 05 01.

Artigo em Inglês | MEDLINE | ID: mdl-35522157

2.

Rigor and reproducibility in human brain organoid research: Where we are and where we need to go.

Sandoval, Soraya O; Cappuccio, Gerarda; Kruth, Karina; Osenberg, Sivan; Khalil, Saleh M; Méndez-Albelo, Natasha M; Padmanabhan, Krishnan; Wang, Daifeng; Niciu, Mark J; Bhattacharyya, Anita; Stein, Jason L; Sousa, André M M; Waxman, Elisa A; Buttermore, Elizabeth D; Whye, Dosh; Sirois, Carissa L; Williams, Aislinn; Maletic-Savatic, Mirjana; Zhao, Xinyu.

Stem Cell Reports ; 2024 May 10.

Artigo em Inglês | MEDLINE | ID: mdl-38759644

3.

High-content screening identifies a small molecule that restores AP-4-dependent protein trafficking in neuronal models of AP-4-associated hereditary spastic paraplegia.

Saffari, Afshin; Brechmann, Barbara; Böger, Cedric; Saber, Wardiya Afshar; Jumo, Hellen; Whye, Dosh; Wood, Delaney; Wahlster, Lara; Alecu, Julian E; Ziegler, Marvin; Scheffold, Marlene; Winden, Kellen; Hubbs, Jed; Buttermore, Elizabeth D; Barrett, Lee; Borner, Georg H H; Davies, Alexandra K; Ebrahimi-Fakhari, Darius; Sahin, Mustafa.

Nat Commun ; 15(1): 584, 2024 Jan 17.

Artigo em Inglês | MEDLINE | ID: mdl-38233389

4.

Cortical neurons obtained from patient-derived iPSCs with GNAO1 p.G203R variant show altered differentiation and functional properties.

Benedetti, Maria Cristina; D'andrea, Tiziano; Colantoni, Alessio; Silachev, Denis; de Turris, Valeria; Boussadia, Zaira; Babenko, Valentina A; Volovikov, Egor A; Belikova, Lilia; Bogomazova, Alexandra N; Pepponi, Rita; Whye, Dosh; Buttermore, Elizabeth D; Tartaglia, Gian Gaetano; Lagarkova, Maria A; Katanaev, Vladimir L; Musayev, Ilya; Martinelli, Simone; Fucile, Sergio; Rosa, Alessandro.

Heliyon ; 10(5): e26656, 2024 Mar 15.

Artigo em Inglês | MEDLINE | ID: mdl-38434323

5.

A Robust Pipeline for the Multi-Stage Accelerated Differentiation of Functional 3D Cortical Organoids from Human Pluripotent Stem Cells.

Whye, Dosh; Wood, Delaney; Saber, Wardiya Afshar; Norabuena, Erika M; Makhortova, Nina R; Sahin, Mustafa; Buttermore, Elizabeth D.

Curr Protoc ; 3(1): e641, 2023 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-36633423

6.

High-Content Small Molecule Screen Identifies a Novel Compound That Restores AP-4-Dependent Protein Trafficking in Neuronal Models of AP-4-Associated Hereditary Spastic Paraplegia.

Saffari, Afshin; Brechmann, Barbara; Boeger, Cedric; Saber, Wardiya Afshar; Jumo, Hellen; Whye, Dosh; Wood, Delaney; Wahlster, Lara; Alecu, Julian; Ziegler, Marvin; Scheffold, Marlene; Winden, Kellen; Hubbs, Jed; Buttermore, Elizabeth; Barrett, Lee; Borner, Georg; Davies, Alexandra; Sahin, Mustafa; Ebrahimi-Fakhari, Darius.

Res Sq ; 2023 Jun 12.

Artigo em Inglês | MEDLINE | ID: mdl-37398196

7.

Dynamic 3D Combinatorial Generation of hPSC-Derived Neuromesodermal Organoids With Diverse Regional and Cellular Identities.

Whye, Dosh; Wood, Delaney; Kim, Kristina H; Chen, Cidi; Makhortova, Nina; Sahin, Mustafa; Buttermore, Elizabeth D.

Curr Protoc ; 2(10): e568, 2022 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-36264199

8.

Proteomic assessment of a cell model of spinal muscular atrophy.

Wu, Chia-Yen; Whye, Dosh; Glazewski, Lisa; Choe, Leila; Kerr, Douglas; Lee, Kelvin H; Mason, Robert W; Wang, Wenlan.

BMC Neurosci ; 12: 25, 2011 Mar 08.

Artigo em Inglês | MEDLINE | ID: mdl-21385431

9.

Applying Deep Neural Network Analysis to High-Content Image-Based Assays.

Yang, Samuel J; Lipnick, Scott L; Makhortova, Nina R; Venugopalan, Subhashini; Fan, Minjie; Armstrong, Zan; Schlaeger, Thorsten M; Deng, Liyong; Chung, Wendy K; O'Callaghan, Liadan; Geraschenko, Anton; Whye, Dosh; Berndl, Marc; Hazard, Jon; Williams, Brian; Narayanaswamy, Arunachalam; Ando, D Michael; Nelson, Philip; Rubin, Lee L.

SLAS Discov ; 24(8): 829-841, 2019 09.

Artigo em Inglês | MEDLINE | ID: mdl-31284814

10.

Efficient differentiation of mouse embryonic stem cells into motor neurons.

Wu, Chia-Yen; Whye, Dosh; Mason, Robert W; Wang, Wenlan.

J Vis Exp ; (64): e3813, 2012 Jun 09.

Artigo em Inglês | MEDLINE | ID: mdl-22711008

11.

Targeting nonclassical oncogenes for therapy in T-ALL.

Subramaniam, Prem S; Whye, Dosh W; Efimenko, Evgeni; Chen, Jianchung; Tosello, Valeria; De Keersmaecker, Kim; Kashishian, Adam; Thompson, Mary Ann; Castillo, Mireia; Cordon-Cardo, Carlos; Davé, Utpal P; Ferrando, Adolfo; Lannutti, Brian J; Diacovo, Thomas G.

Cancer Cell ; 21(4): 459-72, 2012 Apr 17.

Artigo em Inglês | MEDLINE | ID: mdl-22516257

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