Detalhe da pesquisa
1.
Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation.
Cell
; 170(4): 701-713.e11, 2017 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28781166
2.
Cryo-EM analyses of dimerized spliceosomes provide new insights into the functions of B complex proteins.
EMBO J
; 43(6): 1065-1088, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38383864
3.
Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome.
Mol Cell
; 80(1): 127-139.e6, 2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33007253
4.
Structural insights into how Prp5 proofreads the pre-mRNA branch site.
Nature
; 596(7871): 296-300, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34349264
5.
Molecular architecture of the human 17S U2 snRNP.
Nature
; 583(7815): 310-313, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32494006
6.
Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds.
Mol Cell
; 70(2): 265-273.e8, 2018 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-29656923
7.
The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated Bact complex.
Genes Dev
; 31(23-24): 2416-2429, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29330354
8.
The spliceosome: design principles of a dynamic RNP machine.
Cell
; 136(4): 701-18, 2009 Feb 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-19239890
9.
Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.
Mol Cell
; 64(2): 307-319, 2016 10 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-27720643
10.
Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Nature
; 542(7641): 318-323, 2017 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28076346
11.
Dynamic protein-protein interaction wiring of the human spliceosome.
Mol Cell
; 45(4): 567-80, 2012 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-22365833
12.
Multiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome.
Nucleic Acids Res
; 46(22): 12126-12138, 2018 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30335160
13.
The Sm-core mediates the retention of partially-assembled spliceosomal snRNPs in Cajal bodies until their full maturation.
Nucleic Acids Res
; 46(7): 3774-3790, 2018 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29415178
14.
The Prp8 RNase H-like domain inhibits Brr2-mediated U4/U6 snRNA unwinding by blocking Brr2 loading onto the U4 snRNA.
Genes Dev
; 26(21): 2422-34, 2012 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23124066
15.
SUMO conjugation to spliceosomal proteins is required for efficient pre-mRNA splicing.
Nucleic Acids Res
; 45(11): 6729-6745, 2017 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28379520
16.
ATPγS stalls splicing after B complex formation but prior to spliceosome activation.
RNA
; 22(9): 1329-37, 2016 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27411562
17.
Multiple protein-protein interactions converging on the Prp38 protein during activation of the human spliceosome.
RNA
; 22(2): 265-77, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26673105
18.
Exon definition complexes contain the tri-snRNP and can be directly converted into B-like precatalytic splicing complexes.
Mol Cell
; 38(2): 223-35, 2010 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-20417601
19.
An ancient mechanism for splicing control: U11 snRNP as an activator of alternative splicing.
Mol Cell
; 37(6): 821-33, 2010 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-20347424
20.
Stable tri-snRNP integration is accompanied by a major structural rearrangement of the spliceosome that is dependent on Prp8 interaction with the 5' splice site.
RNA
; 21(11): 1993-2005, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26385511