Detalhe da pesquisa
1.
Oxindole derivatives as inhibitors of TAK1 kinase.
Bioorg Med Chem Lett
; 21(6): 1724-7, 2011 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21316225
2.
2-Anilino-4-aryl-1,3-thiazole inhibitors of valosin-containing protein (VCP or p97).
Bioorg Med Chem Lett
; 20(5): 1677-9, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20137940
3.
Design, synthesis, and biological activity of potent and selective inhibitors of blood coagulation factor Xa.
J Med Chem
; 47(16): 4089-99, 2004 Jul 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-15267248
4.
Discovery and SAR of methylated tetrahydropyranyl derivatives as inhibitors of isoprenylcysteine carboxyl methyltransferase (ICMT).
J Med Chem
; 54(14): 5031-47, 2011 Jul 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-21661760
5.
Characterization of the cellular and antitumor effects of MPI-0479605, a small-molecule inhibitor of the mitotic kinase Mps1.
Mol Cancer Ther
; 10(12): 2267-75, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21980130
6.
Chemical proteomics identifies Nampt as the target of CB30865, an orphan cytotoxic compound.
Chem Biol
; 17(6): 659-64, 2010 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20609415
7.
Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as potent inhibitors of nicotinamide phosphoribosyltransferase (Nampt).
J Med Chem
; 53(24): 8734-46, 2010 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21080724
8.
Discovery of N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine, a potent apoptosis inducer and efficacious anticancer agent with high blood brain barrier penetration.
J Med Chem
; 52(8): 2341-51, 2009 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19296653
9.
Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activity.
J Med Chem
; 51(15): 4771-9, 2008 Aug 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-18651728
10.
Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis.
Gastroenterology
; 132(7): 2422-37, 2007 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-17570216
11.
The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex--Part 2.
Bioorg Med Chem Lett
; 16(4): 1060-4, 2006 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16289811
12.
The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex.
Bioorg Med Chem Lett
; 15(21): 4752-6, 2005 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16125385