RESUMO
INTRODUCTION: Diffusion-weighted imaging (DWI) as part of multiparametric magnetic resonance imaging (mpMRI) is an important sequence for the detection of prostate cancer (PCa). The objective of this retrospective analysis was to evaluate changes in apparent diffusion coefficient (ADC) measurements in biopsy-proven PCa undergoing TULSA-PRO (MR-guided transurethral ultrasound ablation of the prostate) at 3.0 T after 1, 3, and 6-12 months posttreatment. METHODS: Nineteen patients underwent follow-up examinations after 1, 3, and 6-12 months including mpMRI at 3.0 T and urological-clinical examinations with quantitative analysis of ADCs. RESULTS: In PCa, a significant increase of ADC values after 6-12 months was measured after TULSA-PRO treatment by 29.1% (pre-TULSA: 0.79 ± 0.16 × 10-3 mm2/s, 6-12 months: 1.02 ± 0.35 × 10-3 mm2/s), while the corresponding value in the reference tissue decreased by 48.5% (pre-TULSA: 1.20 ± 0.15 × 10-3 mm2/s, 6-12 months: 0.91 ± 0.29 × 10-3 mm2/s). The mean ADC values in the early follow-up groups at 1 and 3 months did not change significantly. CONCLUSION: DWI with ADC as part of mpMRI can serve as a biomarker to dynamically monitor the follow-up after TULSA after 6-12 months. For early posttreatment progression, it is not suitable due to too many confounding variables.
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Neoplasias da Próstata , Masculino , Humanos , Estudos Retrospectivos , Neoplasias da Próstata/diagnóstico por imagem , Neoplasias da Próstata/cirurgia , Imagem de Difusão por Ressonância Magnética/métodos , Próstata/diagnóstico por imagem , Próstata/cirurgia , Próstata/patologia , BiópsiaRESUMO
The COVID-19 pandemic has resulted in significant morbidity and mortality worldwide. To prevent severe infection, mass COVID-19 vaccination campaigns with several vaccine types are currently underway. We report pathological and immunological findings in 8 patients who developed vaccine-induced immune thrombotic thrombocytopenia (VITT) after administration of SARS-CoV-2 vaccine ChAdOx1 nCoV-19. We analyzed patient material using enzyme immune assays, flow cytometry and heparin-induced platelet aggregation assay and performed autopsies on two fatal cases. Eight patients (5 female, 3 male) with a median age of 41.5 years (range, 24 to 53) were referred to us with suspected thrombotic complications 6 to 20 days after ChAdOx1 nCoV-19 vaccination. All patients had thrombocytopenia at admission. Patients had a median platelet count of 46.5 x109/L (range, 8 to 92). Three had a fatal outcome and 5 were successfully treated. Autopsies showed arterial and venous thromboses in various organs and the occlusion of glomerular capillaries by hyaline thrombi. Sera from VITT patients contain high titer antibodies against platelet factor 4 (PF4) (OD 2.59±0.64). PF4 antibodies in VITT patients induced significant increase in procoagulant markers (P-selectin and phosphatidylserine externalization) compared to healthy volunteers and healthy vaccinated volunteers. The generation of procoagulant platelets was PF4 and heparin dependent. We demonstrate the contribution of antibody-mediated platelet activation in the pathogenesis of VITT.
Assuntos
COVID-19 , Trombocitopenia , Adulto , Autoanticorpos , Plaquetas , Vacinas contra COVID-19 , ChAdOx1 nCoV-19 , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pandemias , SARS-CoV-2 , Trombocitopenia/induzido quimicamente , Vacinação/efeitos adversos , Adulto JovemRESUMO
OBJECTIVES: To retrospectively determine incidence of early arterial blood flow stasis and its influencing factors during resin-based radioembolization (RE) of liver tumours. METHODS: Data of patients undergoing resin-based RE from 06/2006-12/2013 were reviewed. Second RE procedures of the same liver lobe were excluded. 90-yttrium dose was calculated according to the body surface area method. Data were categorized according to RE without full dose application because of early stasis and with full dose application. Clinical/procedural characteristics were recorded. Logistic regression was performed to identify associations between clinical/procedural characteristics and early stasis. RESULTS: 362 patients [220 male; mean age 62 years (range 26-90)] underwent 416 RE sessions with early stasis occurring in 103 REs (24.8 %). Highest incidence and degree of stasis were observed in breast cancer metastases [42.6 % (20/47); 55.8 % of mean intended dose administered]. Independent risk factors were: metastasized breast cancer (odds ratio [OR] 2.18, p = 0.02), liver tumour-burden <25 % and 25-50 % (ORs 5.33, 15.64; p < 0.0001), tumour hypovascularity (OR 2.70, p = 0.04), previous bevacizumab therapy (OR 2.79, p = 0.0009) and concurrent chemotherapy (OR 8.69, p < 0.0001). CONCLUSION: Early stasis was observed in 24.8 % of resin-based REs. In the presence of the identified risk factors, extra care should be taken during microsphere administration. KEY POINTS: ⢠Early arterial blood flow stasis is a known problem of resin-based RE. ⢠The study showed that early stasis occurs in 25 % of REs. ⢠Several clinical and procedural factors are associated with early stasis. ⢠In patients at risk extra care should be taken during RE.
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Braquiterapia/métodos , Embolia/terapia , Embolização Terapêutica/métodos , Neoplasias Hepáticas/terapia , Microesferas , Radioisótopos de Ítrio/uso terapêutico , Adulto , Idoso , Idoso de 80 Anos ou mais , Embolia/etiologia , Feminino , Humanos , Incidência , Neoplasias Hepáticas/complicações , Neoplasias Hepáticas/diagnóstico , Masculino , Pessoa de Meia-Idade , Compostos Radiofarmacêuticos/uso terapêutico , Estudos Retrospectivos , Fatores de RiscoRESUMO
OBJECTIVES: Our aim was to retrospectively evaluate the occurrence of respiratory motion artefacts in patients undergoing dynamic liver magnetic resonance (MR) either with gadoxetate disodium or gadobutrol. METHODS: Two hundred and thirty liver MR studies (115 with gadobutrol, 115 with gadoxetate disodium) were analysed. Respiratory motion artefacts on dynamic 3D T1-weighted MR images (pre-contrast, arterial, venous, and late-dynamic phase) were assessed using a five-point rating scale. Severe motion was defined as a score ≥ 4. Mean motion scores were compared with the Mann-Whitney-U-test. The chi-squared-test was used for dichotomous comparisons. RESULTS: Mean motion scores for gadoxetate disodium and gadobutrol showed no relevant differences for each phase of the dynamic contrast series (pre-contrast: 1.85 ± 0.70 vs. 1.88 ± 0.57, arterial: 1.85 ± 0.81 vs. 1.87 ± 0.74, venous: 1.82 ± 0.67 vs. 1.74 ± 0.64, late-dynamic: 1.75 ± 0.62 vs. 1.79 ± 0.63; p = 0.469, 0.557, 0.382 and 0.843, respectively). Severe motion artefacts had a similar incidence using gadoxetate disodium and gadobutrol (11/460 [2.4%] vs. 7/460 [1.5%]; p = 0.341). CONCLUSIONS: Gadoxetate disodium is associated with equivalent motion scores compared to gadobutrol in dynamic liver MRI. In addition, both contrast agents demonstrated a comparable and acceptable rate of severe respiratory motion artefacts. KEY POINTS: ⢠Gadobutrol and gadoxetate disodium showed comparable motion scores in dynamic phase imaging. ⢠The incidence of severe motion artefacts was pronounced in arterial phase imaging. ⢠Adverse respiratory side effects were not recorded in 115 examinations with gadoxetate disodium.
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Artefatos , Meios de Contraste , Gadolínio DTPA , Cirrose Hepática/patologia , Hepatopatias/patologia , Compostos Organometálicos , Adulto , Idoso , Idoso de 80 Anos ou mais , Artérias , Feminino , Humanos , Imageamento Tridimensional , Imageamento por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Movimento (Física) , Respiração , Estudos RetrospectivosRESUMO
OBJECTIVES: To compare systematically quantitative MRI, MR spectroscopy (MRS), and different histological methods for liver fat quantification in order to identify possible incongruities. METHODS: Fifty-nine consecutive patients with liver disorders were examined on a 3 T MRI system. Quantitative MRI was performed using a dual- and a six-echo variant of the modified Dixon (mDixon) sequence, calculating proton density fat fraction (PDFF) maps, in addition to single-voxel MRS. Histological fat quantification included estimation of the percentage of hepatocytes containing fat vesicles as well as semi-automatic quantification (qHisto) using tissue quantification software. RESULTS: In 33 of 59 patients, the hepatic fat fraction was >5% as determined by MRS (maximum 45%, mean 17%). Dual-echo mDixon yielded systematically lower PDFF values than six-echo mDixon (mean difference 1.0%; P < 0.001). Six-echo mDixon correlated excellently with MRS, qHisto, and the estimated percentage of hepatocytes containing fat vesicles (R = 0.984, 0.967, 0.941, respectively, all P < 0.001). Mean values obtained by the estimated percentage of hepatocytes containing fat were higher by a factor of 2.5 in comparison to qHisto. Six-echo mDixon and MRS showed the best agreement with values obtained by qHisto. CONCLUSIONS: Six-echo mDixon, MRS, and qHisto provide the most robust and congruent results and are therefore most appropriate for reliable quantification of liver fat. KEY POINTS: ⢠Six-echo mDixon correlates excellently with MRS, qHisto, and the estimated percentage of fat-containing hepatocytes. ⢠Six-echo mDixon, MRS, and qHisto provide the most robust and congruent results. ⢠Dual-echo mDixon yields systematically lower PDFF values than six-echo mDixon. ⢠The percentage of fat-containing hepatocytes is 2.5-fold higher than fat fraction determined by qHisto. ⢠Performance characteristics and systematic differences of the various methods should be considered.
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Fígado Gorduroso/patologia , Adolescente , Adulto , Idoso , Feminino , Hepatócitos/patologia , Técnicas Histológicas , Humanos , Imageamento por Ressonância Magnética/métodos , Espectroscopia de Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Software , Adulto JovemRESUMO
PURPOSE: To implement and evaluate high spatial resolution three-dimensional MR contrast-enhanced angiography (3D-CEMRA) of the thighs using a blood pool contrast agent (BPCA) using the quadrature body coil only in patients with peripheral arterial occlusive disease (PAOD) in cases receiver coils cannot be used at 1.5 Tesla (T). MATERIALS AND METHODS: Nineteen patients (mean age: 68.7 ± 11.2 years; range, 38-83 years) with known PAOD (Fontaine stages; III: 16, IV: 3) prospectively underwent 3D-CEMRA at 1.5T with a noninterpolated voxel size of 0.49 × 0.49 × 0.48 mm(3) . Digital subtraction angiography (DSA) was available for comparison in all patients. Two readers independently evaluated movement artifacts, overall image quality of 3D-CEMRA, and grade of stenosis as compared to DSA. SNR and CNR levels were quantified. RESULTS: The 3D-CEMRA was successfully completed in all patients. Patient movement artifacts that affected stenosis grading occurred in 3/38 thighs. Overall image quality was rated excellent in 15/38, good in 12/38, and diagnostic in 8/38 thighs. Stenosis grading matched with that in DSA in 35/38 thighs. High SNR and CNR were measured in all vessels. CONCLUSION: The 0.125 mm(3) spatial resolution 3D-CEMRA of the thighs with a BPCA is feasible using a quadrature body coil exclusively with excellent image quality despite long acquisition times. J. Magn. Reson. Imaging 2014;40:996-1001. © 2014 Wiley Periodicals, Inc.
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Arteriopatias Oclusivas/fisiopatologia , Gadolínio , Aumento da Imagem/instrumentação , Angiografia por Ressonância Magnética/instrumentação , Compostos Organometálicos , Doença Arterial Periférica/fisiopatologia , Coxa da Perna/fisiopatologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Arteriopatias Oclusivas/patologia , Velocidade do Fluxo Sanguíneo/fisiologia , Meios de Contraste , Desenho de Equipamento , Análise de Falha de Equipamento , Estudos de Viabilidade , Feminino , Humanos , Aumento da Imagem/métodos , Imageamento Tridimensional/instrumentação , Imageamento Tridimensional/métodos , Angiografia por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Doença Arterial Periférica/patologia , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Coxa da Perna/irrigação sanguínea , Coxa da Perna/patologiaRESUMO
PURPOSE: To evaluate the use of the recently proposed ultrafast B1 (+) mapping approach DREAM (Dual Refocusing Echo Acquisition Mode) for a refinement of patient adaptive radiofrequency (RF) shimming. MATERIALS AND METHODS: Volumetric DREAM B1 (+) calibration scans centered in the upper abdomen were acquired in 20 patients and three volunteers with written informed consent at a clinical dual source 3 Tesla (T) MR system. Based on these data, RF transmit settings were optimized by central-slice based RF-shimming (CS-RF shim) and by a refined, multi-slice adaptive approach (MS-RF shim). Simulations were performed to compare flip angle accuracy and B1 (+) homogeneity (cv = stddev/mean) achieved by CS-RF shim versus MS-RF shim for transversal and coronal slices, and for volume shimming on the spine. RESULTS: By MS-RF shim, mean deviation from nominal flip angle was reduced to less than 11% in all slices, all targets, and all subjects. Relative improvements in B1 (+) cv (MS-RF shim versus CS-RF) were up to 14%/39%/47% in transversal slices/coronal slices/ spine area. CONCLUSION: Volumetric information about B1 (+) can be used to further improve the accuracy and homogeneity of the B1 (+) field yielding higher diagnostic confidence, and will also be of value for various quantitative methods which are sensitive to flip angle imperfections.
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Algoritmos , Aumento da Imagem/métodos , Interpretação de Imagem Assistida por Computador/métodos , Imageamento Tridimensional/métodos , Imageamento por Ressonância Magnética/métodos , Imagem Corporal Total/métodos , Adulto , Idoso , Humanos , Pessoa de Meia-Idade , Ondas de Rádio , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Adulto JovemRESUMO
OBJECTIVES: To evaluate diffusion-weighted MRI with acquisition of three b-values and calculation of fractioned ADCs for response evaluation of neuroendocrine liver metastases undergoing selective internal radiotherapy (SIRT). METHODS: Ten consecutive patients with neuroendocrine liver metastases underwent MRI before and following SIRT. Diffusion-weighted imaging included acquisition of the b-values 0, 50 and 800 s/mm(2) and calculation of ADC(50,800), ADC(0,50) and ADC(0,800) maps. According to therapy response, lesions were categorised into group A [≥20% reduction of the longest diameter (LD) in comparison to baseline MRI] and group B (<20% reduction of the LD). RESULTS: Twelve out of 31 metastases were categorised as group A and 19 out of 31 metastases were categorised as group B. Pretherapeutic values of ADC(0,800) and ADC(50,800) did not differ significantly between the two groups; however, ADC(0,50) was 32% lower in group A (P = 0.049). ADC(0,800) and ADC(50,800) increased significantly after therapy in both groups, however, group differences were not statistically significant. Conversely, the increase in ADC(0,50) was about a factor of 7 larger in group A than in group B (P = 0.023). CONCLUSIONS: Our study showed that the ADC(0,50) is a promising biomarker for response assessment of neuroendocrine liver metastases following SIRT. KEY POINTS: ⢠Diffusion-weighted MRI offers new information about neuroendocrine hepatic metastases. ⢠Evaluation of perfusion and diffusion components requires fractioned apparent diffusion coefficients (ADCs). ⢠Perfusion effects represented by ADC (0.50) can be observed in neuroendocrine metastases. ⢠Pretherapeutic ADC (0.50) was significantly lower in metastases with a response ≥20%. ⢠Such biomarkers may help evaluate liver metastases in patients undergoing therapy.
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Braquiterapia/métodos , Imagem de Difusão por Ressonância Magnética/métodos , Neoplasias Gastrointestinais/patologia , Neoplasias Gastrointestinais/radioterapia , Neoplasias Hepáticas/diagnóstico , Neoplasias Hepáticas/radioterapia , Tumores Neuroendócrinos/diagnóstico , Tumores Neuroendócrinos/radioterapia , Idoso , Diagnóstico Diferencial , Feminino , Seguimentos , Humanos , Neoplasias Hepáticas/secundário , Masculino , Microesferas , Pessoa de Meia-Idade , Tumores Neuroendócrinos/secundário , Estudos RetrospectivosRESUMO
OBJECTIVES: To evaluate hepatobiliary magnetic resonance imaging (MRI) using Gd-EOB-DTPA in relation to various liver function tests in patients with liver disorders. METHODS: Fifty-one patients with liver disease underwent Gd-EOB-DTPA-enhanced liver MRI. Based on region-of-interest (ROI) analysis, liver signal intensity was calculated using the spleen as reference tissue. Liver-spleen contrast ratio (LSCR) and relative liver enhancement (RLE) were calculated. Serum levels of total bilirubin, gamma glutamyl transpeptidase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT), glutamate dehydrogenase (GLDH), lactate dehydrogenase (LDH), serum albumin level (AL), prothrombin time (PT), creatinine (CR) as well as international normalised ratio (INR) and model for end-stage liver disease (MELD) score were tested for correlation with LSCR and RLE. RESULTS: Pre-contrast LSCR values correlated with total bilirubin (r = -0.39; p = 0.005), GGT (r = -0.37; p = 0.009), AST (r = -0.38; p = 0.013), ALT (r = -0.29; p = 0.046), PT (r = 0.52; p < 0.001), GLDH (r = -0.55; p = 0.044), INR (r = -0.42; p = 0.003), and MELD Score (r = -0.53; p < 0.001). After administration of Gd-EOB-DTPA bilirubin (r = -0.45; p = 0.001), GGT (r = -0.40; p = 0.004), PT (r = 0.54; p < 0.001), AST (r = -0.46; p = 0.002), ALT (r = -0.31; p = 0.030), INR (r = -0.45; p = 0.001) and MELD Score (r = -0.56; p < 0.001) significantly correlated with LSCR. RLE correlated with bilirubin (r = -0.40; p = 0.004), AST (r = -0.38; p = 0.013), PT (r = 0.42; p = 0.003), GGT (r = -0.33; p = 0.020), INR (r = -0.36; p = 0.011) and MELD Score (r = -0.43; p = 0.003). CONCLUSIONS: Liver-spleen contrast ratio and relative liver enhancement using Gd-EOB-DTPA correlate with a number of routinely used biochemical liver function tests, suggesting that hepatobiliary MRI may serve as a valuable biomarker for liver function. The strongest correlation with liver enhancement was found for the MELD Score. KEY POINTS: ⢠Relative enhancement (RLE) of Gd-EOB-DTPA is related to biochemical liver function tests. ⢠Correlation of RLE with bilirubin, ALT, AST, GGT, INR and MELD Score is reverse. ⢠The correlation of relative liver enhancement with prothrombin time is positive. ⢠AST, ALT, GLDH, prothrombin time, INR and MELD Score correlate with pre-contrast liver-spleen contrast ratio. ⢠Such biomarkers may help to evaluate liver function.
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Biomarcadores/sangue , Gadolínio DTPA , Hepatopatias/patologia , Testes de Função Hepática/métodos , Imageamento por Ressonância Magnética/métodos , Adulto , Idoso , Idoso de 80 Anos ou mais , Alanina Transaminase/sangue , Bilirrubina/sangue , Meios de Contraste , Feminino , Glutamato Desidrogenase/sangue , Humanos , L-Lactato Desidrogenase/sangue , Hepatopatias/sangue , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Estudos Retrospectivos , Albumina Sérica/metabolismo , gama-Glutamiltransferase/sangueRESUMO
This work presents a novel method for the rapid and simultaneous measurement of R1 and R2* relaxation rates. It is based on a dynamic short repetition time steady-state spoiled multigradient-echo sequence and baseline R1 and B1 measurements. The accuracy of the approach was evaluated in simulations and a phantom experiment. The sensitivity and specificity of the method were demonstrated in one volunteer and in four patients with intracranial tumors during carbogen inhalation. We utilized (ΔR2*, ΔR1) scatter plots to analyze the multiparametric response amplitude of each voxel within an area of interest. In normal tissue R2* decreased and R1 increased moderately in response to the elevated blood and tissue oxygenation. A strong negative ΔR2* and ΔR1 response was observed in veins and some tumor areas. Moderate positive ΔR2* and ΔR1 response amplitudes were found in fluid-rich tissue as in cerebrospinal fluid, peritumoral edema, and necrotic areas. The multiparametric approach was shown to increase the specificity and sensitivity of oxygen-enhanced MRI compared to measuring ΔR2* or ΔR1 alone. It is thus expected to provide an optimal tool for the identification of tissue areas with low oxygenation, e.g., in tumors with compromised oxygen supply.
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Imageamento por Ressonância Magnética/métodos , Imagem Molecular/métodos , Neoplasias/diagnóstico , Neoplasias/metabolismo , Oximetria/métodos , Oxigênio/sangue , Administração por Inalação , Idoso , Feminino , Humanos , Aumento da Imagem/métodos , Interpretação de Imagem Assistida por Computador/métodos , Masculino , Pessoa de Meia-Idade , Oxigênio/administração & dosagem , Reprodutibilidade dos Testes , Sensibilidade e EspecificidadeRESUMO
PURPOSE: To evaluate the effect of dual-source parallel radiofrequency (RF) transmission with patient-adaptive local RF shimming on image quality, image contrast, and diagnostic confidence at routine clinical cardiac magnetic resonance (MR) imaging with use of a 3.0-T dual-channel transmit whole-body MR system. MATERIALS AND METHODS: Written informed consent was obtained from all patients, and the study protocol was approved by the local institutional review board. Cardiac MR imaging was performed in 28 patients by using a 3.0-T MR unit equipped with a dual-source RF transmission system. The effect of conventional versus dual-source RF transmission on steady-state free precession (SSFP) cine sequences and turbo spin-echo (TSE) black-blood (BB) sequences was evaluated. The homogeneity of the B1 field and contrast-to-noise ratios (CNRs) were measured and tested for statistical significance with the paired t test. Images were analyzed qualitatively for homogeneity, the presence of off-resonance artifacts, and diagnostic confidence independently by two readers. Statistical significance was assessed with the Wilcoxon signed rank test. Inter- and intraobserver agreement was assessed with κ statistics. RESULTS: Quantitative image analysis revealed that B1 homogeneity and CNR were significantly improved for images acquired with dual-source RF transmission compared with conventional RF transmission (P = .005). The quality of SSFP and TSE BB images of the left and the right ventricles showed a significant improvement with respect to image homogeneity and diagnostic confidence as evaluated by the readers (P = .0001, κ > 0.74). As a side effect, off-resonance artifacts were significantly reduced on SSFP images (P = .0001, κ > 0.76). CONCLUSION: Dual-source parallel RF transmission significantly improves image homogeneity, image contrast, and diagnostic confidence compared with conventional RF transmission of cardiac SSFP and TSE BB sequences.
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Cardiomiopatias/diagnóstico , Doença das Coronárias/diagnóstico , Imagem Cinética por Ressonância Magnética/métodos , Adulto , Idoso , Análise de Variância , Artefatos , Feminino , Humanos , Aumento da Imagem/métodos , Interpretação de Imagem Assistida por Computador/métodos , Masculino , Pessoa de Meia-Idade , Ondas de Rádio , Estatísticas não ParamétricasRESUMO
PURPOSE: To improve image quality of diffusion-weighted body magnetic resonance imaging (MRI) with background body signal suppression (DWIBS) at 3.0 T. MATERIALS AND METHODS: In 30 patients and eight volunteers, a diffusion-weighted spin-echo echo-planar imaging sequence with short TI inversion recovery (STIR) fat suppression was applied and repeated using slice-selective gradient reversal (SSGR) and/or dual-source parallel radiofrequency (RF) transmission (TX). The quality of diffusion-weighted images and gray scale inverted maximum intensity projections (MIP) were visually assessed by intraindividual comparison with respect to the level of fat suppression and signal homogeneity. Moreover, the contrast between lesions/lymph nodes and background (C(lb)) was analyzed in the MIP reconstructions. RESULTS: By combining STIR with SSGR, fat suppression was significantly improved (P < 0.001) and C(lb) was increased two times. The use of TX allowed the reduction of acquisition time and improved image quality with regard to signal homogeneity (P < 0.001) and fat suppression (P = 0.005). CONCLUSION: DWIBS at 3.0 T can be improved by using SSGR and TX.
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Imagem de Difusão por Ressonância Magnética/métodos , Aumento da Imagem/métodos , Imagem Corporal Total/métodos , Tecido Adiposo , Adulto , Idoso , Imagem Ecoplanar , Feminino , Humanos , Interpretação de Imagem Assistida por Computador/métodos , Masculino , Pessoa de Meia-Idade , Estatísticas não ParamétricasRESUMO
OBJECTIVE: The purpose of this study was to investigate the prevalence of incidental deep venous thrombosis (DVT) in patients with clinically suspected peripheral arterial occlusive disease (PAOD) using contrast-enhanced MR angiography (MRA) with a blood pool contrast agent. SUBJECTS AND METHODS: Two hundred fifty-nine MRA examinations with blood pool contrast agent in 245 consecutive patients (161 men; age range, 36-92 years), yielding a total of 4102 assessable arterial and venous vessel segments, were assessed with regard to the rate of incidentally observed acute and organized DVT and arterial stenosis grades. Incidental DVT was confirmed using duplex ultrasound. Contralateral nondiseased veins served as internal controls. The relationship between PAOD stages and acute and organized DVT was investigated using chi-square tests and a Mann-Whitney U test. RESULTS: Arterial stenosis grading using MRA with blood pool contrast agent revealed less than 50% luminal stenosis in 78% of segments (3199/4102), 50% or greater stenosis in 8% of segments (317/4102), and occlusion in 14% of segments (586/4102). Incidental DVT was observed in 26 of 245 patients (11%) (acute DVT was seen in 10 patients and 26 segments; organized DVT was seen in 17 patients and 35 segments; and one patient had both acute and organized DVT). All incidentally diagnosed cases of DVT were confirmed by duplex ultrasound. Internal controls revealed no false-positive or -negative findings (26 patients and 172 segments). Incidental acute DVT was significantly more common among patients without arterial stenosis greater than 50% (p < 0.05). Otherwise, there was no significant relationship between Fontaine PAOD stages and the occurrence of acute (p = 0.688) or organized (p = 0.995) DVT. CONCLUSION: Incidental DVT was prevalent in 11% of patients with clinically suspected PAOD. MRA with blood pool contrast agent has a potential role in the simultaneous assessment of arteries and veins and can detect concomitant venous disease affecting therapeutic management.
Assuntos
Arteriopatias Oclusivas/diagnóstico , Meios de Contraste , Gadolínio , Angiografia por Ressonância Magnética/métodos , Compostos Organometálicos , Doenças Vasculares Periféricas/diagnóstico , Trombose Venosa/diagnóstico , Adulto , Idoso , Idoso de 80 Anos ou mais , Arteriopatias Oclusivas/diagnóstico por imagem , Arteriopatias Oclusivas/epidemiologia , Distribuição de Qui-Quadrado , Feminino , Humanos , Interpretação de Imagem Assistida por Computador , Achados Incidentais , Masculino , Pessoa de Meia-Idade , Doenças Vasculares Periféricas/diagnóstico por imagem , Doenças Vasculares Periféricas/epidemiologia , Prevalência , Estatísticas não Paramétricas , Ultrassonografia Doppler Dupla , Trombose Venosa/diagnóstico por imagem , Trombose Venosa/epidemiologiaRESUMO
PURPOSE: To prospectively compare T2-weighted single-shot turbo spin-echo (TSE) sequences performed with parallel and conventional radiofrequency (RF) transmission at 3.0 T for liver lesion detection, image quality, lesion conspicuity, and lesion contrast. MATERIALS AND METHODS: After written informed consent and institutional review board approval, 52 consecutive patients (32 men, 20 women; mean age, 56.6 years ± 13.7 [standard deviation]) underwent routine magnetic resonance (MR) imaging with a clinical 3.0-T unit. Two independent readers reviewed images acquired with conventional and dual-source parallel RF transmission for detection of focal liver lesions, with separate reading of a third radiologist, including all available imaging findings, clinical history, and histopathologic findings, as reference. Image quality and lesion conspicuity were rated on five- and three-point evaluation scales, respectively. Contrast ratios between focal liver lesions and adjacent liver parenchyma were calculated. Significance was determined by using nonparametric Wilcoxon signed-rank and marginal homogeneity tests. RESULTS: With the reference standard, 106 index lesions were identified in 22 patients. Detection rate significantly improved from 87% (92 of 106) to 97% (103 of 106) (reader 1) and from 85% (90 of 106) to 96% (102 of 106) (reader 2) with parallel RF transmission (reader 1, P = .0078; reader 2, P = .002). Quality of parallel RF transmission images was assigned scores significantly higher, compared with quality of conventional RF transmission images (mean for reader 1, 2.88 ± 0.73 vs 4.04 ± 0.44; mean for reader 2, 2.81 ± 0.72 vs 4.04 ± 0.39; P < .0001 for both). Lesion conspicuity scores were significantly higher on parallel RF transmission images, compared with conventional RF transmission images (mean for reader 1, 2.02 ± 0.64 vs 2.92 ± 0.27; mean for reader 2, 2.06 ± 0.67 vs 2.90 ± 0.30; P < .0001 for both). Contrast ratios were significantly higher with parallel RF transmission (P < .05). CONCLUSION: Compared with conventional RF transmission, parallel RF transmission significantly improved liver lesion detection rate, image quality, lesion conspicuity, and lesion contrast. SUPPLEMENTAL MATERIAL: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.11101429/-/DC1.
Assuntos
Hepatopatias/diagnóstico , Imageamento por Ressonância Magnética/métodos , Adulto , Idoso , Artefatos , Meios de Contraste , Dextranos , Feminino , Humanos , Aumento da Imagem/métodos , Imageamento Tridimensional , Fígado , Hepatopatias/patologia , Nanopartículas de Magnetita , Masculino , Pessoa de Meia-Idade , Compostos Organometálicos , Estudos Prospectivos , Ondas de Rádio , Estatísticas não ParamétricasRESUMO
PURPOSE: To prospectively and intraindividually compare single-source radiofrequency (RF) excitation and dual-source parallel RF excitation in 3.0-T magnetic resonance (MR) imaging of the spine. MATERIALS AND METHODS: Institutional review board approval and written informed patient consent were obtained. The RF power of a 3.0-T MR imaging system was distributed to two ports of the body coil of the system by using independent RF transmit channels. The maximum B(1) field strength for dual-source parallel RF excitation was maintained, as compared with single-source RF excitation. The repetition time was reduced according to the revised RF setup with dual-source parallel RF excitation while maintaining specific energy absorption limitations. Thirty patients were examined with and without dual-source parallel RF excitation. Diagnostic quality was assessed independently by two radiologists according to a four-point grading system. Image contrast ratios (CRs) were calculated between reference tissues and vertebrae for single-source RF excitation and dual-source parallel RF excitation. RESULTS: The mean acceleration achieved with dual-source parallel RF excitation was 36% (range, 18%-50%). The total imaging duration of a three-station total spinal examination was reduced by one-third by using dual-source parallel RF transmission. For all cases investigated, diagnostic image quality without significant differences between the two methods and with a good interobserver agreement was achieved (Kendall tau-b, 0.50-0.84). The observed image contrast changes were predominantly small (<0.10 in 15 of 24 CRs), though they were significantly different (P < .05). CONCLUSION: While shortening examination times by approximately one-third, the dual-source parallel RF transmission mode in MR imaging of the spine yielded diagnostic image quality comparable to that with the conventional single-source RF transmission mode.
Assuntos
Aumento da Imagem/métodos , Imageamento por Ressonância Magnética/métodos , Doenças da Coluna Vertebral/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Meios de Contraste , Feminino , Humanos , Imageamento por Ressonância Magnética/instrumentação , Masculino , Pessoa de Meia-Idade , Compostos Organometálicos , Estudos Prospectivos , Ondas de RádioRESUMO
PURPOSE: To prospectively compare the image quality and homogeneity of magnetic resonance (MR) images obtained by using a dual-source parallel radiofrequency (RF) excitation body MR imaging system with parallel transmission and independent RF shimming with the image quality and homogeneity of single-source MR images obtained by using standard sequences for routine clinical use in patients at 3.0 T. MATERIALS AND METHODS: After institutional review board approval and informed patient consent were obtained, a dual-source parallel RF excitation 3.0-T MR system with independent RF shimming and parallel transmission technology was used to examine 28 patients and was compared with a standard 3.0-T MR system with single RF transmission. The RF power was distributed to the independent ports of the system body coil by using two RF transmission sources with full software control, enabling independent control of the phase and amplitude of the RF waveforms. Axial T2-weighted fast spin-echo (SE) and diffusion-weighted (DW) liver images, axial T2-weighted fast SE pelvic images, and sagittal T1- and T2-weighted fast SE spinal images were obtained by using dual- and single-source RF excitation. Two radiologists independently evaluated the images for homogeneity and image quality. Statistical significance was calculated by using the nonparametric Wilcoxon signed rank test. Interobserver agreement was determined by using Cohen kappa and Kendall tau-b tests. RESULTS: Image quality comparisons revealed significantly better results with dual-source rather than single-source RF excitation at T2-weighted liver MR imaging (P = .001, kappa = 1.00) and better results at DW liver imaging at a statistical trend level (P = .066, tau-b > 0.7). Owing to reduced local energy deposition, fewer acquisitions and shorter repetition times could be implemented with dual-source RF excitation pelvic and spinal MR imaging, with image acquisition accelerating by 18%, 33%, and 50% compared with the acquisitions with single-source RF excitation. Image quality did not differ significantly between the two MR techniques (P > .05, tau-b > 0.5). CONCLUSION: Dual-source parallel RF excitation body MR imaging enables reduced dielectric shading, improved homogeneity of the RF magnetic induction field, and accelerated imaging at 3.0 T.
Assuntos
Imageamento por Ressonância Magnética/métodos , Adulto , Idoso , Artefatos , Feminino , Humanos , Aumento da Imagem/métodos , Fígado/patologia , Masculino , Pessoa de Meia-Idade , Pelve/patologia , Estudos Prospectivos , Ondas de Rádio , Coluna Vertebral/patologia , Estatísticas não ParamétricasRESUMO
The consistent determination of changes in the transverse relaxation rate R(2)* (ΔR(2)*) is essential for the mapping of the effect of hyperoxic and hypercapnic respiratory challenges, which enables the noninvasive assessment of blood oxygenation changes and vasoreactivity by MRI. The purpose of this study was to compare the performance of two different methods of ΔR(2)* quantification from dynamic multigradient-echo data: (A) subtraction of R(2)* values calculated from monoexponential decay functions; and (B) computation of ΔR(2)* echo-wise from signal intensity ratios. A group of healthy volunteers (n = 12) was investigated at 3.0 T, and the brain tissue response to carbogen and CO(2)-air inhalation was registered using a dynamic multigradient-echo sequence with high temporal and spatial resolution. Results of the ΔR(2)* quantification obtained by the two methods were compared with respect to the quality of the voxel-wise ΔR(2)* response, the number of responding voxels and the behaviour of the 'global' response of all voxels with significant R(2)* changes. For the two ΔR(2)* quantification methods, we found no differences in the temporal variation of the voxel-wise ΔR(2)* responses or in the detection sensitivity. The maximum change in the 'global' response was slightly smaller when ΔR(2)* was derived from signal intensity ratios. In conclusion, this first methodological comparison shows that both ΔR(2)* quantifications, from monoexponential approximation as well as from signal intensity ratios, are applicable for the monitoring of R(2)* changes during respiratory challenges.
Assuntos
Mapeamento Encefálico/métodos , Dióxido de Carbono/metabolismo , Imageamento por Ressonância Magnética/métodos , Adulto , Encéfalo/anatomia & histologia , Encéfalo/metabolismo , Feminino , Humanos , Hipercapnia/metabolismo , Hiperóxia/metabolismo , Processamento de Imagem Assistida por Computador/métodos , Masculino , Oxigênio/metabolismo , Adulto JovemRESUMO
PURPOSE: To compare two DeltaR2* quantification methods for analyzing the response of intracranial tumors to different breathing gases. The determination of changes in the magnetic resonance imaging (MRI) relaxation rate R2* (DeltaR2*), induced by hyperoxic and hypercapnic respiratory challenges, enables the noninvasive assessment of blood oxygenation changes and vasoreactivity. MATERIALS AND METHODS: Sixteen patients with various intracranial tumors were examined at 3.0 T. The response to respiratory challenges was registered using a dynamic multigradient-echo sequence with high temporal and spatial resolution. At each dynamic step, DeltaR2* was derived in two different ways: 1) by subtraction of R2* values obtained from monoexponential decay functions, 2) by computing DeltaR2* echo-wise from signal intensity ratios. The sensitivity for detection of responding voxels and the behavior of the "global" response were investigated. RESULTS: Significantly more responding voxels (about 4%) were found for method (1). The "global" response was independent from the chosen quantification method but showed slightly larger changes (about 6%) when DeltaR2* was derived from method (1). CONCLUSION: Similar results were observed for the two methods, with a slightly higher detection sensitivity of responding voxels when DeltaR2* was obtained from monoexponential approximation.
Assuntos
Neoplasias Encefálicas/patologia , Hipercapnia/metabolismo , Hiperóxia/metabolismo , Imageamento por Ressonância Magnética/métodos , Respiração , Adulto , Idoso , Encéfalo/metabolismo , Encéfalo/patologia , Neoplasias Encefálicas/metabolismo , Neoplasias Encefálicas/secundário , Dióxido de Carbono/administração & dosagem , Dióxido de Carbono/metabolismo , Imagem Ecoplanar/métodos , Feminino , Glioblastoma/metabolismo , Glioblastoma/patologia , Humanos , Processamento de Imagem Assistida por Computador/métodos , Linfoma não Hodgkin/metabolismo , Linfoma não Hodgkin/patologia , Masculino , Meningioma/metabolismo , Meningioma/patologia , Pessoa de Meia-Idade , Oxigênio/administração & dosagem , Oxigênio/metabolismo , Sensibilidade e EspecificidadeRESUMO
PURPOSE: To compare two magnetic resonance (MR) contrast mechanisms, R*(2) BOLD and balanced SSFP, for the dynamic monitoring of the cerebral response to (C)O(2) respiratory challenges. MATERIALS AND METHODS: Carbogen and CO(2)-enriched air were delivered to 9 healthy volunteers and 1 glioblastoma patient. The cerebral response was recorded by two-dimensional (2D) dynamic multi-gradient-echo and passband-balanced steady-state free precession (bSSFP) sequences, and local changes of R*(2) and signal intensity were investigated. Detection sensitivity was analyzed by statistical tests. An exponential signal model was fitted to the global response function delivered by each sequence, enabling quantitative comparison of the amplitude and temporal behavior. RESULTS: The bSSFP signal changes during carbogen and CO(2)/air inhalation were lower compared with R*(2) BOLD (ca. 5% as opposed to 8-13%). The blood-oxygen-level-dependent (BOLD) response amplitude enabled differentiation between carbogen and CO(2)/air by a factor of 1.4-1.6, in contrast to bSSFP, where differentiation was not possible. Furthermore, motion robustness and detection sensitivity were higher for R*(2) BOLD. CONCLUSION: Both contrast mechanisms are well suited to dynamic (C)O(2)-enhanced MR imaging, although the R*(2) BOLD mechanism was demonstrated to be superior in several respects for the chosen application. This study suggests that the R*(2) BOLD and bSSFP-response characteristics are related to different physiologic mechanisms.
Assuntos
Encéfalo/patologia , Dióxido de Carbono/química , Glioblastoma/terapia , Imageamento por Ressonância Magnética/métodos , Oxigênio/sangue , Adulto , Idoso , Neoplasias Encefálicas/metabolismo , Neoplasias Encefálicas/patologia , Neoplasias Encefálicas/terapia , Diagnóstico por Imagem/métodos , Feminino , Glioblastoma/metabolismo , Glioblastoma/patologia , Humanos , Masculino , Oxigênio/química , Sensibilidade e Especificidade , Fatores de TempoRESUMO
OBJECTIVE: To investigate the impact of a higher magnetic field strength of 3 Tesla (T) on the detection rate of cortical lesions in multiple sclerosis (MS) patients, in particular using a dedicated double inversion recovery (DIR) pulse sequence. METHODS: Thirty-four patients with clinically isolated syndromes or definite MS were included. All patients underwent magnetic resonance imaging (MRI) at 1.5 T and 3 T, including T2-weighted turbo spin echo (TSE), fluid-attenuated inversion recovery (FLAIR) and DIR sequences. All images were analysed for focal lesions categorised according to their anatomical location. RESULTS: The total number of detected lesions was higher at 3 T across all pulse sequences. We observed significantly higher numbers of lesions involving the cortex at 3 T using a DIR sequence. DIR at 3 T showed 192% more pure intracortical (p < 0.001) and 30% more mixed grey matter-white matter lesions (p = 0.008). No significant increase in cortical lesions could be detected on the FLAIR and T2-weighted images. Using the T2-weighted and FLAIR sequences, significantly more lesions could be detected at 3 T in the infratentorial, periventricular and juxtacortical white matter. CONCLUSION: DIR brain MR imaging at 3 T substantially improves the sensitivity of the detection of cortical lesions compared with the standard magnetic field strength of 1.5 T.