Detalhe da pesquisa
1.
Calcium Enabled Remote Loading of a Weak Acid Into pH-sensitive Liposomes and Augmented Cytosolic Delivery to Cancer Cells via the Proton Sponge Effect.
Pharm Res
; 39(6): 1181-1195, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35229237
2.
Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity.
Molecules
; 25(21)2020 Oct 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33105798
3.
Functional CRISPR and shRNA Screens Identify Involvement of Mitochondrial Electron Transport in the Activation of Evofosfamide.
Mol Pharmacol
; 95(6): 638-651, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30979813
4.
Effects of KPC Variant and Porin Genotype on the In Vitro Activity of Meropenem-Vaborbactam against Carbapenem-Resistant Enterobacteriaceae.
Antimicrob Agents Chemother
; 63(3)2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30617090
5.
An agent-based model for drug-radiation interactions in the tumour microenvironment: Hypoxia-activated prodrug SN30000 in multicellular tumour spheroids.
PLoS Comput Biol
; 14(10): e1006469, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30356233
6.
Studies Towards Hypoxia-Activated Prodrugs of PARP Inhibitors.
Molecules
; 24(8)2019 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-31010230
7.
Benzotriazine Di-Oxide Prodrugs for Exploiting Hypoxia and Low Extracellular pH in Tumors.
Molecules
; 24(14)2019 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31295864
8.
PEG-Benzaldehyde-Hydrazone-Lipid Based PEG-Sheddable pH-Sensitive Liposomes: Abilities for Endosomal Escape and Long Circulation.
Pharm Res
; 35(8): 154, 2018 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29855807
9.
AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia.
Blood
; 126(10): 1193-202, 2015 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26116659
10.
DNA Adduct Profiles Predict in Vitro Cell Viability after Treatment with the Experimental Anticancer Prodrug PR104A.
Chem Res Toxicol
; 30(3): 830-839, 2017 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28140568
11.
Hypoxia-activated prodrugs: paths forward in the era of personalised medicine.
Br J Cancer
; 114(10): 1071-7, 2016 May 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27070712
12.
Radical Chemistry and Cytotoxicity of Bioreductive 3-Substituted Quinoxaline Di-N-Oxides.
Chem Res Toxicol
; 29(8): 1310-24, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27380897
13.
Phase I/II study of the hypoxia-activated prodrug PR104 in refractory/relapsed acute myeloid leukemia and acute lymphoblastic leukemia.
Haematologica
; 100(7): 927-34, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25682597
14.
Zinc finger nuclease knock-out of NADPH:cytochrome P450 oxidoreductase (POR) in human tumor cell lines demonstrates that hypoxia-activated prodrugs differ in POR dependence.
J Biol Chem
; 288(52): 37138-53, 2013 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24196959
15.
Novel nitroimidazole alkylsulfonamides as hypoxic cell radiosensitisers.
Bioorg Med Chem
; 22(7): 2123-32, 2014 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24650701
16.
FSL-61 is a 6-nitroquinolone fluorogenic probe for one-electron reductases in hypoxic cells.
Biochem J
; 452(1): 79-86, 2013 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23480813
17.
Endovascular removal of a large free-floating thrombus of the descending thoracic aorta using the AngioVac system.
J Vasc Surg Cases Innov Tech
; 10(3): 101460, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38591019
18.
Clinical relevance and therapeutic predictive ability of hypoxia biomarkers in head and neck cancer tumour models.
Mol Oncol
; 2024 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38426642
19.
Cross-bridged cyclen or cyclam Co(III) complexes containing cytotoxic ligands as hypoxia-activated prodrugs.
Inorg Chem
; 52(13): 7688-98, 2013 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23773210
20.
Variability of the capsular anatomy in the rotator interval region of the shoulder.
J Shoulder Elbow Surg
; 22(6): 856-61, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23177168