Detalhe da pesquisa
1.
Membrane lipid remodeling modulates γ-secretase processivity.
J Biol Chem
; 299(4): 103027, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36805335
2.
Uncoupling proteins: Martin Klingenberg's contributions for 40â¯years.
Arch Biochem Biophys
; 657: 41-55, 2018 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30217511
3.
Intramembrane proteolysis of ß-amyloid precursor protein by γ-secretase is an unusually slow process.
Biophys J
; 108(5): 1229-37, 2015 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25762334
4.
Homodimerization Protects the Amyloid Precursor Protein C99 Fragment from Cleavage by γ-Secretase.
Biochemistry
; 54(40): 6149-52, 2015 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26403946
5.
Generation of Alzheimer disease-associated amyloid ß42/43 peptide by γ-secretase can be inhibited directly by modulation of membrane thickness.
J Biol Chem
; 287(25): 21326-34, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22532566
6.
Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms.
J Neurosci
; 30(26): 8974-83, 2010 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-20592218
7.
Beta-amyloid precursor protein mutants respond to gamma-secretase modulators.
J Biol Chem
; 285(23): 17798-810, 2010 Jun 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-20348104
8.
Reconstitution of gamma-secretase activity.
Nat Cell Biol
; 5(5): 486-8, 2003 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12679784
9.
Effective sample preparation procedure for the analysis of free neutral steroids, free steroid acids and sterol sulfates in different tissues by GC-MS.
J Steroid Biochem Mol Biol
; 211: 105880, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33757894
10.
Microbiota-derived short chain fatty acids modulate microglia and promote Aß plaque deposition.
Elife
; 102021 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33845942
11.
Inhibition of gamma-secretase by the CK1 inhibitor IC261 does not depend on CK1delta.
Bioorg Med Chem Lett
; 20(9): 2958-63, 2010 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20350806
12.
Photo-controlled delivery of very long chain fatty acids to cell membranes and modulation of membrane protein function.
Biochim Biophys Acta Biomembr
; 1862(5): 183200, 2020 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31972163
13.
Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.
Biochemistry
; 48(6): 1183-97, 2009 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-19159235
14.
Bexarotene Binds to the Amyloid Precursor Protein Transmembrane Domain, Alters Its α-Helical Conformation, and Inhibits γ-Secretase Nonselectively in Liposomes.
ACS Chem Neurosci
; 9(7): 1702-1713, 2018 07 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-29717863
15.
Chemical cross-linking provides a model of the gamma-secretase complex subunit architecture and evidence for close proximity of the C-terminal fragment of presenilin with APH-1.
J Biol Chem
; 283(50): 34677-86, 2008 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-18801744
16.
Intramembrane proteolysis of GXGD-type aspartyl proteases is slowed by a familial Alzheimer disease-like mutation.
J Biol Chem
; 283(44): 30121-8, 2008 Oct 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-18768471
17.
Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation.
Proc Natl Acad Sci U S A
; 99(13): 8666-71, 2002 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-12048259
18.
The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity.
EMBO J
; 23(24): 4738-48, 2004 Dec 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-15549135
19.
PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.
J Biol Chem
; 277(42): 39062-5, 2002 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-12198112
20.
Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production.
Proc Natl Acad Sci U S A
; 99(12): 8025-30, 2002 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-12048239