Detalhe da pesquisa
1.
Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Cell
; 170(2): 249-259.e25, 2017 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28669536
2.
Comparative Analysis of Pharmacodynamics in the C3HeB/FeJ Mouse Tuberculosis Model for DprE1 Inhibitors TBA-7371, PBTZ169, and OPC-167832.
Antimicrob Agents Chemother
; 65(11): e0058321, 2021 10 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34370580
3.
Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase.
Antimicrob Agents Chemother
; 60(10): 6271-80, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27503647
4.
Mouse model for efficacy testing of antituberculosis agents via intrapulmonary delivery.
Antimicrob Agents Chemother
; 56(7): 3957-9, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22547626
5.
A novel metabolite of antituberculosis therapy demonstrates host activation of isoniazid and formation of the isoniazid-NAD+ adduct.
Antimicrob Agents Chemother
; 56(1): 28-35, 2012 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-22037847
6.
Importance of confirming data on the in vivo efficacy of novel antibacterial drug regimens against various strains of Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 56(2): 731-8, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22143517
7.
Comparative studies evaluating mouse models used for efficacy testing of experimental drugs against Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 55(3): 1237-47, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21135176
8.
Novel pyridopyrazine and pyrimidothiazine derivatives as FtsZ inhibitors.
Bioorg Med Chem
; 19(23): 7120-8, 2011 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22024272
9.
Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds.
PLoS One
; 15(1): e0227224, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-31905374
10.
Testing of experimental compounds in a relapse model of tuberculosis using granulocyte-macrophage colony-stimulating factor gene-disrupted mice.
Antimicrob Agents Chemother
; 53(1): 306-8, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18852269
11.
Discovery, synthesis, and biological evaluation of piperidinol analogs with anti-tuberculosis activity.
Bioorg Med Chem
; 17(10): 3588-94, 2009 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19386501
12.
Pyrazolo[1,5- a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis.
ACS Infect Dis
; 5(2): 239-249, 2019 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30485737
13.
Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA.
Life Sci Alliance
; 1(3): e201800025, 2018 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-30456352
14.
Pentacyclic nitrofurans with in vivo efficacy and activity against nonreplicating Mycobacterium tuberculosis.
PLoS One
; 9(2): e87909, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24505329
15.
Bayesian models leveraging bioactivity and cytotoxicity information for drug discovery.
Chem Biol
; 20(3): 370-8, 2013 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-23521795
16.
Effects of P-MAPA Immunomodulator on Toll-Like Receptors and p53: Potential Therapeutic Strategies for Infectious Diseases and Cancer.
Infect Agent Cancer
; 7(1): 14, 2012 Jun 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22709446
17.
Evaluation of a 2-pyridone, KRQ-10018, against Mycobacterium tuberculosis in vitro and in vivo.
Antimicrob Agents Chemother
; 52(4): 1513-5, 2008 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-18268091
18.
In vivo adaptation of the Wayne model of latent tuberculosis.
Infect Immun
; 75(5): 2621-5, 2007 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-17283091