Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Inhibition of Aurora-A/N-Myc Protein-Protein Interaction Using Peptidomimetics: Understanding the Role of Peptide Cyclization.

Dawber, Robert S; Gimenez, Diana; Batchelor, Matthew; Miles, Jennifer A; Wright, Megan H; Bayliss, Richard; Wilson, Andrew J.

Chembiochem ; 25(2): e202300649, 2024 01 15.

Artigo em Inglês | MEDLINE | ID: mdl-37907395

2.

Chemical biology tools for protein labelling: insights into cell-cell communication.

Wright, Megan H.

Biochem J ; 480(18): 1445-1457, 2023 09 27.

Artigo em Inglês | MEDLINE | ID: mdl-37732646

3.

Chemical Proteomics of Host-Microbe Interactions.

Wright, Megan H.

Proteomics ; 18(18): e1700333, 2018 09.

Artigo em Inglês | MEDLINE | ID: mdl-29745013

4.

New developments in probing and targeting protein acylation in malaria, leishmaniasis and African sleeping sickness.

Ritzefeld, Markus; Wright, Megan H; Tate, Edward W.

Parasitology ; 145(2): 157-174, 2018 02.

Artigo em Inglês | MEDLINE | ID: mdl-28270257

5.

Chemical Probes Unravel an Antimicrobial Defense Response Triggered by Binding of the Human Opioid Dynorphin to a Bacterial Sensor Kinase.

Wright, Megan H; Fetzer, Christian; Sieber, Stephan A.

J Am Chem Soc ; 139(17): 6152-6159, 2017 05 03.

Artigo em Inglês | MEDLINE | ID: mdl-28350441

6.

Making a Long Journey Short: Alkyne Functionalization of Natural Product Scaffolds.

Lehmann, Johannes; Wright, Megan H; Sieber, Stephan A.

Chemistry ; 22(14): 4666-78, 2016 Mar 24.

Artigo em Inglês | MEDLINE | ID: mdl-26752308

7.

N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis.

Tate, Edward W; Bell, Andrew S; Rackham, Mark D; Wright, Megan H.

Parasitology ; 141(1): 37-49, 2014 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-23611109

8.

Activation of fluoride anion as nucleophile in water with data-guided surfactant selection.

Sharma, Krishna; McCorry, Alison; Boobier, Samuel; Mottram, James; Napier, Rachel; Ashworth, Ian W; Blacker, A John; Kapur, Nikil; Warriner, Stuart L; Wright, Megan H; Nguyen, Bao N.

Chem Sci ; 15(15): 5764-5774, 2024 Apr 17.

Artigo em Inglês | MEDLINE | ID: mdl-38638222

9.

A role for the vesicle-associated tubulin binding protein ARL6 (BBS3) in flagellum extension in Trypanosoma brucei.

Price, Helen P; Hodgkinson, Michael R; Wright, Megan H; Tate, Edward W; Smith, Barbara A; Carrington, Mark; Stark, Meg; Smith, Deborah F.

Biochim Biophys Acta ; 1823(7): 1178-91, 2012 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-22609302

10.

A fluorescent photoaffinity probe for formyl peptide receptor 1 labelling in living cells.

Field, Devon H; White, Jack S; Warriner, Stuart L; Wright, Megan H.

RSC Chem Biol ; 4(3): 216-222, 2023 Mar 08.

Artigo em Inglês | MEDLINE | ID: mdl-36908701

11.

Catalase: A critical node in the regulation of cell fate.

Baker, Alison; Lin, Chi-Chuan; Lett, Casey; Karpinska, Barbara; Wright, Megan H; Foyer, Christine H.

Free Radic Biol Med ; 199: 56-66, 2023 04.

Artigo em Inglês | MEDLINE | ID: mdl-36775107

12.

Pseudomonas aeruginosa utilizes the host-derived polyamine spermidine to facilitate antimicrobial tolerance.

Hasan, Chowdhury M; Pottenger, Sian; Green, Angharad E; Cox, Adrienne A; White, Jack S; Jones, Trevor; Winstanley, Craig; Kadioglu, Aras; Wright, Megan H; Neill, Daniel R; Fothergill, Joanne L.

JCI Insight ; 7(22)2022 11 22.

Artigo em Inglês | MEDLINE | ID: mdl-36194492

13.

Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes.

Bell, Andrew S; Yu, Zhiyong; Hutton, Jennie A; Wright, Megan H; Brannigan, James A; Paape, Daniel; Roberts, Shirley M; Sutherell, Charlotte L; Ritzefeld, Markus; Wilkinson, Anthony J; Smith, Deborah F; Leatherbarrow, Robin J; Tate, Edward W.

J Med Chem ; 63(14): 7740-7765, 2020 07 23.

Artigo em Inglês | MEDLINE | ID: mdl-32575985

14.

Redox regulation of cell proliferation: Bioinformatics and redox proteomics approaches to identify redox-sensitive cell cycle regulators.

Foyer, Christine H; Wilson, Michael H; Wright, Megan H.

Free Radic Biol Med ; 122: 137-149, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29605447

15.

Global Profiling and Inhibition of Protein Lipidation in Vector and Host Stages of the Sleeping Sickness Parasite Trypanosoma brucei.

Wright, Megan H; Paape, Daniel; Price, Helen P; Smith, Deborah F; Tate, Edward W.

ACS Infect Dis ; 2(6): 427-441, 2016 Jun 10.

Artigo em Inglês | MEDLINE | ID: mdl-27331140

16.

Global analysis of protein N-myristoylation and exploration of N-myristoyltransferase as a drug target in the neglected human pathogen Leishmania donovani.

Wright, Megan H; Paape, Daniel; Storck, Elisabeth M; Serwa, Remigiusz A; Smith, Deborah F; Tate, Edward W.

Chem Biol ; 22(3): 342-54, 2015 Mar 19.

Artigo em Inglês | MEDLINE | ID: mdl-25728269

17.

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

Thinon, Emmanuelle; Serwa, Remigiusz A; Broncel, Malgorzata; Brannigan, James A; Brassat, Ute; Wright, Megan H; Heal, William P; Wilkinson, Anthony J; Mann, David J; Tate, Edward W.

Nat Commun ; 5: 4919, 2014 Sep 26.

Artigo em Inglês | MEDLINE | ID: mdl-25255805

18.

Structure-based design of potent and selective Leishmania N-myristoyltransferase inhibitors.

Hutton, Jennie A; Goncalves, Victor; Brannigan, James A; Paape, Daniel; Wright, Megan H; Waugh, Thomas M; Roberts, Shirley M; Bell, Andrew S; Wilkinson, Anthony J; Smith, Deborah F; Leatherbarrow, Robin J; Tate, Edward W.

J Med Chem ; 57(20): 8664-70, 2014 Oct 23.

Artigo em Inglês | MEDLINE | ID: mdl-25238611

19.

Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.

Wright, Megan H; Clough, Barbara; Rackham, Mark D; Rangachari, Kaveri; Brannigan, James A; Grainger, Munira; Moss, David K; Bottrill, Andrew R; Heal, William P; Broncel, Malgorzata; Serwa, Remigiusz A; Brady, Declan; Mann, David J; Leatherbarrow, Robin J; Tewari, Rita; Wilkinson, Anthony J; Holder, Anthony A; Tate, Edward W.

Nat Chem ; 6(2): 112-21, 2014 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-24451586

20.

Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation.

Guttery, David S; Poulin, Benoit; Ramaprasad, Abhinay; Wall, Richard J; Ferguson, David J P; Brady, Declan; Patzewitz, Eva-Maria; Whipple, Sarah; Straschil, Ursula; Wright, Megan H; Mohamed, Alyaa M A H; Radhakrishnan, Anand; Arold, Stefan T; Tate, Edward W; Holder, Anthony A; Wickstead, Bill; Pain, Arnab; Tewari, Rita.

Cell Host Microbe ; 16(1): 128-40, 2014 Jul 09.

Artigo em Inglês | MEDLINE | ID: mdl-25011111

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