Detalhe da pesquisa
1.
MSG-10: a Phase 2 study of oral ibrexafungerp (SCY-078) following initial echinocandin therapy in non-neutropenic patients with invasive candidiasis.
J Antimicrob Chemother
; 74(10): 3056-3062, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31304536
2.
Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles.
Antimicrob Agents Chemother
; 62(5)2018 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29507073
3.
Assessment of a pretomanid analogue library for African trypanosomiasis: Hit-to-lead studies on 6-substituted 2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazine 8-oxides.
Bioorg Med Chem Lett
; 28(2): 207-213, 2018 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29191556
4.
Preclinical Pharmacokinetics and Pharmacodynamic Target of SCY-078, a First-in-Class Orally Active Antifungal Glucan Synthesis Inhibitor, in Murine Models of Disseminated Candidiasis.
Antimicrob Agents Chemother
; 61(4)2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28137806
5.
Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity.
Bioorg Med Chem
; 25(20): 5433-5440, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28807574
6.
Serotonin and Pulmonary Hypertension; Sex and Drugs and ROCK and Rho.
Compr Physiol
; 12(4): 4103-4118, 2022 08 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-36036567
7.
SAR of 2-amino and 2,4-diamino pyrimidines with in vivo efficacy against Trypanosoma brucei.
Bioorg Med Chem Lett
; 21(10): 2816-9, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21507639
8.
Enfuvirtide cerebrospinal fluid (CSF) pharmacokinetics and potential use in defining CSF HIV-1 origin.
Antivir Ther
; 13(3): 369-74, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18572749
9.
Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase.
J Med Chem
; 61(3): 1182-1203, 2018 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29271204
10.
Identification of Trypanosoma brucei AdoMetDC Inhibitors Using a High-Throughput Mass Spectrometry-Based Assay.
ACS Infect Dis
; 3(7): 512-526, 2017 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-28350440
11.
Enfuvirtide plasma levels and injection site reactions using a needle-free gas-powered injection system (Biojector).
AIDS
; 20(5): 719-23, 2006 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-16514302
12.
Predicting P-glycoprotein substrates by a quantitative structure-activity relationship model.
J Pharm Sci
; 93(4): 957-68, 2004 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-14999732
13.
Benzoxaboroles: a new class of potential drugs for human African trypanosomiasis.
Future Med Chem
; 3(10): 1259-78, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21859301
14.
SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis.
PLoS Negl Trop Dis
; 5(6): e1151, 2011 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-21738803
15.
Automated quantitative and qualitative analysis of metabolic stability: a process for compound selection during drug discovery.
Methods Enzymol
; 357: 285-95, 2002.
Artigo
em Inglês
| MEDLINE | ID: mdl-12424918
16.
Method to screen substrates of apical sodium-dependent bile acid transporter.
AAPS J
; 10(4): 596-605, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-19085111
17.
Design of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus.
Proc Natl Acad Sci U S A
; 104(31): 12772-7, 2007 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-17640899
18.
Influence of charge and steric bulk in the C-24 region on the interaction of bile acids with human apical sodium-dependent bile acid transporter.
Mol Pharm
; 3(3): 282-92, 2006.
Artigo
em Inglês
| MEDLINE | ID: mdl-16749860
19.
Interaction of native bile acids with human apical sodium-dependent bile acid transporter (hASBT): influence of steroidal hydroxylation pattern and C-24 conjugation.
Pharm Res
; 23(7): 1451-9, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16783481
20.
Steady-state brain concentrations of antihistamines in rats: interplay of membrane permeability, P-glycoprotein efflux and plasma protein binding.
Pharmacology
; 72(2): 92-8, 2004 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-15331914