RESUMO
In the title compound, C(18)H(20)N(2)O(3), the dihedral angle between the indole ring system (r.m.s. deviation = 0.018â Å) and the hy-droxy-methyl-enepyrrolidine-2,4-dione plane (r.m.s. deviation = 0.036â Å) is 9.87â (7)°. The keto and enol groups are involved in an intra-molecular O-Hâ¯O hydrogen bond. An intra-molecular C-Hâ¯O inter-action also occurs. The sec-butyl group is disordered over two orientations corresponding to an approximate 180° rotation about the N-C bond, with occupancies of 0.670â (6) and 0.330â (6). In the crystal, mol-ecules are linked into chains along the c axis by C-Hâ¯O hydrogen bonds.
RESUMO
In the title compound, C(20)H(19)N(3)O, the dihedral angles formed by the pyrazolone ring with the two phenyl rings are 64.27â (6) and 17.00â (6)°. The mol-ecular structure is stabilized by intra-molecular N-Hâ¯O and C-Hâ¯O hydrogen bonds. In the crystal, the mol-ecules are linked into chains along the b axis by inter-molecular C-Hâ¯O hydrogen bonds.
RESUMO
In the title compound, C(16)H(19)NO(4), a potent new herbicide, the dihedral angle between the benzene and pyrrolidine rings is 11.09â (8)°. Intra-molecular O-Hâ¯O and C-Hâ¯O hydrogen bonds are observed.
RESUMO
The title compound, C(20)H(19)N(3)O, exists in a keto-enamine tautomeric form. The pyrazolone ring makes dihedral angles of 20.52â (10) and 77.73â (5)° with the two phenyl rings and an intra-molecular N-Hâ¯O hydrogen bond occurs. A weak inter-molecular C-Hâ¯O hydrogen bond is observed in the crystal structure. The allyl group is disordered over two positions, with site-occupancy factors of 0.533â (5) and 0.467â (5).
RESUMO
In the polymeric title complex, [Cu(C(7)H(3)N(2)O(2)S)(2)(H(2)O)(2)](n), the Cu(II) centre is surrounded by three 1,2,3-benzothia-diazole-7-carboxyl-ate and two water mol-ecules. A 1,2,3-benzothia-diazole-7-carboxyl-ate ligand bridges two Cu(II) centres, with a Cuâ¯Cu distance of 9.006â (2)â Å. The four O atoms in the equatorial planes around each Cu(II) centre form a distorted square-planar arrangement, while the distorted square-pyramidal coordination is completed by the symmetry-related N atoms of the bridging 1,2,3-benzothia-diazole-7-carboxyl-ate ligands. In the crystal structure, inter-molecular O-Hâ¯O and O-Hâ¯N hydrogen bonds link the mol-ecules into a three-dimensional supra-molecular network.
RESUMO
In the title compound, C(21)H(23)N(3)O, the dihedral angles formed by the pyrazolone ring with two phenyl rings are 10.38â (8) and 76.94â (6)°. The sec-butyl-amino group is disordered over two positions, with refined site-occupancy factors of 0.730â (4) and 0.270â (4). The compound could potentially be ligand stabilized in the solid state in a keto-enamine tautomeric form. The amine functionality is involved in an intra-molecular N-Hâ¯O hydrogen bond, while weak inter-molecular C-Hâ¯O and C-Hâ¯N hydrogen bonds participate in the formation of the crystal structure.
RESUMO
In the title compound, C(25)H(23)N(3)O(2), the dihedral angles formed by the pyrazolone ring with the three aromatic rings are 14.59â (7), 79.35â (5) and 87.10â (6)°. Three intra-molecular C-Hâ¯O, C-Hâ¯N and N-Hâ¯O hydrogen-bond inter-actions are present. The crystal structure is stabilized by two weak inter-molecular C-Hâ¯O and C-Hâ¯N hydrogen-bond inter-actions.
RESUMO
OBJECTIVE: To study the relationship between the inhibitory effects of Tongxie Yaofang, a compound traditional Chinese herbal medicine, on the contraction of the colonic smooth muscle isolated from rats and calcium mobilization. METHODS: By measuring the tension of the isolated colonic smooth muscle strips, the inhibitory effects of Tongxie Yaofang on the contraction induced by acetylcholine (ACh), KCl and exhausting Ca(2+) of internal calcium store were assessed respectively. RESULTS: Tongxie Yaofang could concentration-dependently inhibit the contraction of isolated rat colonic smooth muscle strips induced by KCl and exhausting the Ca(2+) of internal calcium store. Tongxie Yaofang could also inhibit the tension of the second contractile phase induced by ACh (P<0.01, vs control), but had no influence on the first contractile phase. CONCLUSION: Tongxie Yaofang can inhibit the contraction of isolated rat colonic smooth muscle strips mainly by preventing the influx of extracellular Ca(2+), which may be associated with blocking voltage-dependent channel, store-operated channel and receptor-operated channel, but not by preventing the release of internal Ca(2+) from calcium store.
Assuntos
Cálcio/metabolismo , Colo/efeitos dos fármacos , Medicamentos de Ervas Chinesas/farmacologia , Contração Muscular/efeitos dos fármacos , Animais , Colo/fisiologia , Masculino , Músculo Liso , Ratos , Transdução de Sinais/efeitos dos fármacosRESUMO
The title compound, C(18)H(23)NO(5), a potential herbicide, has an enol group that is intra-molecularly hydrogen bonded to a keto O atom. The dihedral angle between the six-membered ring formed by the enol group and the aromatic benzene ring is 53.35â (6)°.