Prognostic significance of sarcopenia in patients with hepatocellular carcinoma treated with lenvatinib: A retrospective analysis.

ABSTRACT: Our study investigated the correlation between sarcopenia and clinical outcomes in patients with hepatocellular carcinoma (HCC) treated with lenvatinib. We retrospectively evaluated 40 consecutive patients with unresectable HCC receiving lenvatinib between November 2018 and May 2020 at the First Hospital of Jilin University. Skeletal muscle mass was measured before treatment initiation. Prognostic significance was assessed with univariate and multivariate Cox proportional hazards models. Overall survival (OS) and progression-free survival (PFS) were evaluated for patients with and without sarcopenia. Sarcopenia was present in 23/40 patients (57.5%). After a median follow-up of 9.2 months, patients with sarcopenia had significantly worse OS and PFS compared with those without sarcopenia (OS: 8.4 months [m] vs 14.7 m, P = .02; PFS: 4.2 m vs 9.0 m, P = .04). Multivariate Cox proportional hazards models identified presence of sarcopenia as an independent risk factor for shorter OS (hazard ratio [HR], 0.257; 95% confidence interval [CI], 0.083-0.794; P = .02). In subgroup analysis, sarcopenia was associated with worse survival than non-sarcopenic patients, irrespective of age, Barcelona clinic liver cancer stage, or albumin-bilirubin grade. Our results show sarcopenia may be a predictor of poor prognosis in patients with HCC receiving lenvatinib. Management of sarcopenia is a vital factor for improving survival outcomes in patients with HCC.

Greatly Enhanced Faradic Capacities of 3D Porous Mn3O4/G Composites as Lithium-Ion Anodes and Supercapacitors by C-O-Mn Bonding.

Through C-O-Mn bonding, graphene nanosheets are homogeneously dispersed in porous Mn3O4 to take full advantages of porous Mn3O4 and graphene nanosheets, making the as-formed three-dimensional porous Mn3O4/reduced graphene oxide (rGO) composite exhibit good electrochemical performance. Besides, C-O-Mn bonding is demonstrated to greatly promote the Faradic reactions of the composite, resulting in the enhancement of its real capacity in supercapacitor (SC) electrodes as well as lithium-ion battery (LIB) anodes. By simply fine-tuning the content of graphene (<7 wt %), the composite with 2.8 wt % of rGO delivers a high capacitance of 315 F g-1 at 0.5 A g-1 with a high rate capability of 64.7% at 30 A g-1 and an excellent cycling stability of 105% (5 A g-1, 5000 cycles) as an SC electrode. Also, the one with 6.9 wt % rGO can present a reversible capacity of more than 1500 mAh g-1 at 0.05 A g-1 as the LIB anode, the highest value reported to date, which remains 561 mAh g-1 at 1 A g-1.

[Anemia status and correlation factors in rural regions of Hebei province].

OBJECTIVE: To investigate anemia status and correlation infection factors in rural regions of Hebei province and to find out evidence for preventing and controlling anemia. METHODS: A random-sampling survey was conducted among 3367 houses in Hebei rural areas. The investigation involved economic levels, ages, education levels and occupations of 11,627 questionnaire. The hemoprotein and serum iron were measured. Unconditional logistic regression was performed. RESULTS: The anemia prevalence rate was shown up to 8.4% in rural regions of Hebei province, and in men and women was 5.5% and 11.0%, respectively;mainly in infant (< 2 years old, 27.2%) child bearing age women, the anemia prevalence rate was 11.0%-16.0%. The analysis showed that the main risk factors of anemia were sex and serum iron. CONCLUSION: The anemia prevalence is highest in infant and child bearing age women;supplying of iron should be an important measure for preventing and controlling anemia.

[Village resident nourishment of Hebei investigates with health condition].

OBJECTIVE: To study the changes of the food and nutrients intake and health trends in rural population of Hebei Province since 1992 with the society economy development rapidly. METHODS: Using the multi-stage cluster random sampling method, investigating the body high, weight, blood pressure, Haemoglobin, blood lipids, blood glucose, of 11627 population from 2700 households, and the food consumption and nutrients intakes of 1080 households, to analyses and assess the dietary pattern and mortality of chronic diseases. RESULTS: The results showed that plant food is main food consumption pattern and changed remarkably since the 1992. Although the meat, egg, milk and beat consumption was more than 1992 their intakes are insufficient. The fat food and the salt intakes increased while CA and VA intakes were very insufficient. Weighs values in the school children aged 7-17 were significantly higher than those in 1992. The prevalence of overweight, obese, high blood pressure, diabetes, abnormal blood sugar were 30.4%, 13.4%, 25.9%, 1.8%, 0.98%, respectively in adults aged over 18. The rate of abnormal blood lipid 25.0%, high TG, TC, verge TC, low HDL-C were 15.3%, 3.2%, 3.5%, 10.8%. The standardized prevalence of anemia 8.7% and 16% for preschool children and younger woman respectively. CONCLUSION: The prevalence of overweight, obese, hypertension and abnormal blood lipids in adult population of rural Hebei Province were higher than the average levels in whole country. Sufficient attention should be paid to nutrition diet, heath and some chronic diseases related to nutrition in rural residents, the dietary guidance and nutrition interference need to strengthen and ensure people health.