RESUMO
Bladder cancer is one of the most common cancers in the world. Early detection of bladder cancer is critical to improve the prognosis of the patient. The conventional method for the detection and monitoring of bladder cancer at present is cystoscopy with urinary cytology. Limitations of cystoscopy and urinary cytology have shown the need for better diagnostic method for bladder cancer. Ideally, such assays would be applicable to noninvasively obtained, and be designed not only for diagnosis, but also for monitoring disease recurrence and providing basis for therapy. Consequently, the development of a noninvasive urine-based assay would bring the gospel to both patients and healthcare systems. This article reviews some of the more prominent urine-based biomarkers and related new technologies reported in the literature in recent years.