Detalhe da pesquisa
1.
Anticancer Study of a Novel Pan-HDAC Inhibitor MPT0G236 in Colorectal Cancer Cells.
Int J Mol Sci
; 24(16)2023 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37628767
2.
Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors.
J Enzyme Inhib Med Chem
; 37(1): 226-235, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-34894949
3.
Identification of a dual TAOK1 and MAP4K5 inhibitor using a structure-based virtual screening approach.
J Enzyme Inhib Med Chem
; 36(1): 98-108, 2021 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-33167727
4.
Neuroprotective Studies of Evodiamine in an Okadaic Acid-Induced Neurotoxicity.
Int J Mol Sci
; 22(10)2021 May 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34069531
5.
4-Substituted 2-amino-3,4-dihydroquinazolines with a 3-hairpin turn side chain as novel inhibitors of BACE-1.
Bioorg Chem
; 95: 103135, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31923631
6.
Anti-Inflammatory and Tau Phosphorylation-Inhibitory Effects of Eupatin.
Molecules
; 25(23)2020 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33266202
7.
Moscatilin Ameliorates Tau Phosphorylation and Cognitive Deficits in Alzheimer's Disease Models.
J Nat Prod
; 82(7): 1979-1988, 2019 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31291099
8.
An ensemble machine learning model generates a focused screening library for the identification of CDK8 inhibitors.
Protein Sci
; 33(6): e5007, 2024 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-38723187
9.
1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines histone deacetylase inhibitors are potent cytokine release suppressors.
Chembiochem
; 14(10): 1248-54, 2013 Jul 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-23788254
10.
The study of a novel CDK8 inhibitor E966-0530-45418 that inhibits prostate cancer metastasis in vitro and in vivo.
Biomed Pharmacother
; 162: 114667, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37037092
11.
Design, synthesis, and biological evaluation of indolin-2-one derivatives as novel cyclin-dependent protein kinase 8 (CDK8) inhibitors.
Biomed Pharmacother
; 159: 114258, 2023 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-36708700
12.
Ibuprofen treatment ameliorates memory deficits in rats with collagen-induced arthritis by normalizing aberrant MAPK/NF-κB and glutamatergic pathways.
Eur J Pharmacol
; 933: 175256, 2022 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36088983
13.
Identification and analysis of a selective DYRK1A inhibitor.
Biomed Pharmacother
; 146: 112580, 2022 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-34968920
14.
Discovery of a novel cyclin-dependent kinase 8 inhibitor with an oxindole core for anti-inflammatory treatment.
Biomed Pharmacother
; 146: 112459, 2022 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-34953394
15.
O-methylated flavonol as a multi-kinase inhibitor of leukemogenic kinases exhibits a potential treatment for acute myeloid leukemia.
Phytomedicine
; 100: 154061, 2022 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-35364561
16.
Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-κB and JNK/p38 MAPK activation pathways.
J Biomed Sci
; 18: 28, 2011 May 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-21548916
17.
A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo.
Oncogenesis
; 10(5): 39, 2021 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33986242
18.
Decoy receptor 3 expression in AsPC-1 human pancreatic adenocarcinoma cells via the phosphatidylinositol 3-kinase-, Akt-, and NF-kappa B-dependent pathway.
J Immunol
; 181(12): 8441-9, 2008 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19050262
19.
Intracerebral transplantation of neural stem cells combined with trehalose ingestion alleviates pathology in a mouse model of Huntington's disease.
J Neurosci Res
; 87(1): 26-33, 2009 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18683244
20.
Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo.
Biochim Biophys Acta Mol Cell Res
; 1866(6): 992-1003, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30867138