RESUMO
Currently, optical thermometry has received widespread attention because of its noncontact and wide temperature range, but most of them are based on the application of dual-band optical ratiometric thermometry, so the development of a single-band ratiometric (SBR) optical thermometry, which is easier to analyze and use, is particularly important. In this work, the position of the intervalence charge-transfer (IVCT) band for Na2Gd2-xLaxTi3O10:Pr3+ (x = 0, 0.5, 1.0, 1.5, 2.0) was modulated using Gd/La substitution, enhancing the thermal response difference of Pr3+ 1D2 â 3H4 under charge-transfer band (CTB) and IVCT band excitation, thereby achieving high-sensitivity SBR optical thermometry, and the maximum relative sensitivity (Sr-max) reached 2.95% (at 298 K). In addition, this series of phosphors has high-color-purity red emission, indicating that it has potential for multifield applications.
RESUMO
Development of effective therapeutics for mitigating the COVID-19 pandemic is a pressing global need. Neutralizing antibodies are known to be effective antivirals, as they can be rapidly deployed to prevent disease progression and can accelerate patient recovery without the need for fully developed host immunity. Here, we report the generation and characterization of a series of chimeric antibodies against the receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. Some of these antibodies exhibit exceptionally potent neutralization activities in vitro and in vivo, and the most potent of our antibodies target three distinct non-overlapping epitopes within the RBD. Cryo-electron microscopy analyses of two highly potent antibodies in complex with the SARS-CoV-2 spike protein suggested they may be particularly useful when combined in a cocktail therapy. The efficacy of this antibody cocktail was confirmed in SARS-CoV-2-infected mouse and hamster models as prophylactic and post-infection treatments. With the emergence of more contagious variants of SARS-CoV-2, cocktail antibody therapies hold great promise to control disease and prevent drug resistance.
Assuntos
Anticorpos Neutralizantes/farmacologia , Anticorpos Antivirais/farmacologia , COVID-19/imunologia , COVID-19/prevenção & controle , SARS-CoV-2/imunologia , Glicoproteína da Espícula de Coronavírus/imunologia , Animais , Anticorpos Neutralizantes/imunologia , Anticorpos Antivirais/imunologia , Cricetinae , Modelos Animais de Doenças , Feminino , Masculino , CamundongosRESUMO
A genetic hallmark of malignant germ cell tumours (GCTs) is isochromosome 12p, but oncogenes located in 12p that are specifically expressed in GCT have not yet been identified. SIN3-HDAC complex-associated factor (SINHCAF) is a subunit of the Sin3/histone deacetylase (HDAC) complex, and it defines a Sin3a-Hdac complex variant that is required for the self-renewal of mouse embryonic stem cells. This study demonstrated that SINHCAF is expressed in a vast majority of malignant GCTs and is rarely expressed in somatic malignancy. Fluorescence in situ hybridisation revealed SINHCAF amplification in malignant GCTs. SINHCAF silencing using shRNA reduced anchorage-dependent cell proliferation and tumoursphere formation and inhibited tumour cell migration and invasion in GCT cell lines. Moreover, in the GCT cell line NTERA2/D1, SINHCAF silencing inhibited the expression of genes associated with embryonic stem cells and induced the expression of genes associated with neuronal and white fat cell differentiation. Compared with somatic cell lines, GCT cell lines were more susceptible to HDAC inhibitor treatment. Thus, we identified SINHCAF to be a potential oncogene located in the amplicon of chromosome 12p and showed that SINHCAF was specifically expressed in malignant GCTs. HDAC inhibitor treatment may counteract the oncogenic activity of SINHCAF and is a promising therapeutic approach for GCTs. © 2022 The Pathological Society of Great Britain and Ireland.
Assuntos
Montagem e Desmontagem da Cromatina , Histona Desacetilases , Neoplasias Embrionárias de Células Germinativas , Humanos , Masculino , Montagem e Desmontagem da Cromatina/genética , Cromossomos Humanos Par 12/genética , Inibidores de Histona Desacetilases/farmacologia , Histona Desacetilases/genética , Histona Desacetilases/metabolismo , Hibridização in Situ Fluorescente , Neoplasias Embrionárias de Células Germinativas/genética , OncogenesRESUMO
In 2019, Wen et al. proposed authenticated semi-quantum key distribution (ASQKD) for identity and message using the teleportation of W states and GHZ-like states without pre-shared keys. However, the ASQKD protocol presents a vital issue in the teleportation of W states owing to its inappropriate design. Bob recovers the teleported W states without obtaining the position of the corresponding photons and then returns the recovered photons back to Alice. Hence, the teleportation of W states in Wen et al.'s ASQKD protocol was malfunctioning. Moreover, Wen et al.'s ASQKD protocol requires quantum memory, which strongly disobeys the definition of semi-quantum proposed by Boyer et al. Therefore, in this study, we discover the flaws of Wen et al.'s ASQKD protocol and propose an authenticated semi-quantum key distribution protocol. When compared to Wen et al.'s ASQKD protocol, the proposed ASQKD protocol has the following advantages: legal semi-quantum environment (i.e., does not require quantum memory), reduced quantum hardware requirement (i.e., based only on W states), does not involve classical cryptography (i.e., the hash function), and provided 1.6 times higher qubit efficiency.
Assuntos
ComputadoresRESUMO
Recently, Zhao et al. proposed a semi-quantum bi-signature (SQBS) scheme based on W states with two quantum signers and just one classical verifier. In this study, we highlight three security issues with Zhao et al.'s SQBS scheme. In Zhao et al.'s SQBS protocol, an insider attacker can perform an impersonation attack in the verification phase and an impersonation attack in the signature phase to capture the private key. In addition, an eavesdropper can perform a man-in-the-middle attack to obtain all of the signer's secret information. All of the above three attacks can pass the eavesdropping check. Without considering these security issues, the SQBS protocol could fail to ensure the signer's secret information.
RESUMO
A Gram-negative-staining, endospore-forming, rod-shaped bacterium, designated T1T, was isolated from root nodules of soybean (Glycine max (L.) Merr) in Heilongjiang Province of China. The isolate was identified as a member of the genus Paenibacillus based on phenotypic and phylogenetic characteristics. The 16S rRNA sequence was closely related to that of Paenibacillus sacheonensis SY01T with a similarity of 98.4%. Average nucleotide identity and in silico DNA-DNA hybridization values between strain T1T and P. sacheonensis DSM 23054 T were 81.4% and 25.4%, respectively. The DNA G + C content of strain T1T was 58.2 mol%. meso-Diaminopimelic acid was detected in the cell-wall peptidoglycan. The major cellular fatty acids were anteiso-C15:0, iso-C16:0 and iso-C15:0. The predominant respiratory quinone was MK-7. The polar lipids were diphosphatidylglycerol, phosphatidylglycerol, phosphatidylethanolamine, five unidentified phospholipids, four unidentified aminophospholipids, an unidentified glycolipid and an unidentified lipid. Based on these results, T1T is considered to represent a novel species of the genus Paenibacillus, for which the name Paenibacillus glycinis sp. nov. is proposed. The type strain is T1T (= CGMCC 1.18563 = KCTC43227).
Assuntos
Glycine max , Paenibacillus , Técnicas de Tipagem Bacteriana , China , DNA Bacteriano/genética , Ácidos Graxos/análise , Paenibacillus/genética , Fosfolipídeos/análise , Filogenia , RNA Ribossômico 16S/genética , Análise de Sequência de DNARESUMO
In this study, a series of N-heterocyclic indolyl ligand precursors 2-Py-Py-IndH, 2-Py-Pz-IndH, 2-Py-7-Py-IndH, 2-Py-7-Pz-IndH, and 2-Ox-7-Py-IndH (L1H-L5H) were prepared. The treatment of ligand precursors with 1 equivalent of palladium acetate affords palladium complexes 1-5. All ligand precursors and palladium complexes were characterized by NMR spectroscopy and elemental analysis. The molecular structures of complexes 3 and 5 were determined by single crystal X-ray diffraction techniques. The application of those palladium complexes 1-5 to the Suzuki reaction with aryl halide substrates was examined.
RESUMO
BACKGROUND: Myasthenia gravis (MG) is an autoimmune disease. Dysarthria, dysphagia, and difficulty swallowing as exclusive initial and primary complaints in MG (laryngeal MG) are rare and seldom reported. METHODS: Here we review and analyze the largest series of laryngeal MG patients. RESULTS: A total of 30 patients with laryngeal MG as primary manifestation were found in 20 case reports/series. Dysarthria was the most frequent primary symptom (14/30), followed by dysphagia (11/30), slurred speech (4/30) and dysphonia (1/30). Sixty-three percent visited the otolaryngology department first. Only 23.33% of patients were diagnosed with MG at the first clinic visit. Forty-five percent laryngeal MG patients were acetylcholine receptor (AChR) antibody positive, 52.9% showed decremental response in the repetitive nerve stimulation (RNS) test, and 92.6% were positive in the neostigmine/edrophonium test. Fluctuating weakness was examined in 16 of 30 patients and observed in 14/16 patients. CONCLUSION: Laryngeal MG is a rare and possibly under-diagnosed condition. The patients can present with dysarthria, dysphagia, or difficulty swallowing. Fluctuation in severity of disease by neostigmine/edrophonium test is a typical feature for MG patients. AChR antibody and RNS tests should be included to evaluate the pathologic changes in the neuromuscular junction.
Assuntos
Doenças da Laringe/diagnóstico , Doenças da Laringe/fisiopatologia , Miastenia Gravis/diagnóstico , Miastenia Gravis/fisiopatologia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Autoanticorpos/sangue , Biomarcadores/sangue , Criança , Pré-Escolar , Transtornos de Deglutição/etiologia , Técnicas de Diagnóstico Neurológico , Disartria/etiologia , Disfonia/etiologia , Feminino , Humanos , Doenças da Laringe/complicações , Masculino , Pessoa de Meia-Idade , Miastenia Gravis/complicações , Receptores Colinérgicos/imunologia , Distúrbios da Fala/etiologia , Adulto JovemRESUMO
The extensibility of force field is a key to solve the missing parameter problem commonly found in force field applications. The extensibility of conventional force fields is traditionally managed in the parameterization procedure, which becomes impractical as the coverage of the force field increases above a threshold. A hierarchical atom-type definition (HAD) scheme is proposed to make extensible atom type definitions, which ensures that the force field developed based on the definitions are extensible. To demonstrate how HAD works and to prepare a foundation for future developments, two general force fields based on AMBER and DFF functional forms are parameterized for common organic molecules. The force field parameters are derived from the same set of quantum mechanical data and experimental liquid data using an automated parameterization tool, and validated by calculating molecular and liquid properties. The hydration free energies are calculated successfully by introducing a polarization scaling factor to the dispersion term between the solvent and solute molecules. © 2015 Wiley Periodicals, Inc.
Assuntos
Simulação por Computador , Compostos Orgânicos/químicaRESUMO
Scene-level geographic image classification has been a very challenging problem and has become a research focus in recent years. This paper develops a supervised collaborative kernel coding method based on a covariance descriptor (covd) for scene-level geographic image classification. First, covd is introduced in the feature extraction process and, then, is transformed to a Euclidean feature by a supervised collaborative kernel coding model. Furthermore, we develop an iterative optimization framework to solve this model. Comprehensive evaluations on public high-resolution aerial image dataset and comparisons with state-of-the-art methods show the superiority and effectiveness of our approach.
RESUMO
In this study, a novel photocatalytic fuel cell electro-Fenton (PFC-EF) system was constructed using g-C3 N4 @N-TNA and Ag/CNT@CF as electrodes. The composition, structure, and morphology of the electrodes were obtained. The g-C3 N4 @N-TNA, with its 2.37 eV band gap and 100 mV photovoltage, has excellent excitation properties for sunlight. Ag/CNT@CF with abundant pores, CNT 3D nanostructures, and Ag crystals on the surface can improve the electro-Fenton efficiency. A comparative study of rhodamine B (RhB) degradation was performed in this system. It has been shown that electric fields can greatly enhance the oxidation efficiency of both anode photocatalysis and the cathode electro-Fenton process. Under optimal conditions, RhB can be completely removed by the photoelectro-Fenton (PEF) process. The energy consumption of the PEF system was obtained. The electrical energy per order (EE/O) is only 9.2 kWh/m3 ·order, which is only 16.5% of EF and 2.2% of PFC-EF system. The mineralization current efficiency (MCE) of the PEF system reached 93.3% for a 2-h reaction. Therefore, the PEF system has the advantage of saving energy. The kinetic analysis shows that the RhB removal follows a first-order kinetic law, and the reaction rate constant reaches 0.1304 min-1 , which is approximately 5.2 times larger and 4.0 times larger than the electro-Fenton and PFC-EF processes, respectively. RhB removal is a coupling multimechanism in which an electric field enhances photoelectron migration, Ag loading improves H2 O2 generation, UV light coupled with H2 O2 promotes hydroxyl radical (Ù OH) generation, and the nanoconfinement effect of CNTs promotes Ù OH accumulation in favor of RhB degradation. PRACTITIONER POINTS: Novel efficiency photocatalytic fuel cell electro-Fenton system was constructed. The electric field greatly enhances the photocatalytic fuel cell electro-Fenton system. Multiple coupling mechanisms of UV/H2O2, UV/Fenton and photo-electro-Fenton have been revealed.
Assuntos
Ferro , Poluentes Químicos da Água , Eletrodos , Peróxido de Hidrogênio/química , Ferro/química , Cinética , Oxirredução , Raios Ultravioleta , Poluentes Químicos da Água/químicaRESUMO
Praseodymium (Pr3+) ion and the transition metal vanadium (V5+) ion with d0 electronic configuration can form an intervalence charge transfer (IVCT) band, which can function both as a compensatory channel for its red emission and as a quenching channel, thus affecting the luminescence thermal stability of the phosphors. Research studies reveal that the emission of Pr3+ in the YVO4 matrix can be quenched by the IVCT mechanism, thereby limiting the application of phosphors. As such, the present contribution is based on the solid solution replacement strategy to inhibit the constitutent of the IVCT quenching channel and thus improve thermal stability. Therefore, phosphonium (P5+) with a valence state matching V5+ and a similar ion radius was selected for the V/P substitution. It lacks a d0 electron configuration, preventing the formation of an IVCT band with Pr3+ and thereby inhibiting the construction of the quenching channels to enhance thermal stability. While the empirical formula of IVCT indicates a decrease in the IVCT energy level from 3.32438 to 3.06251 eV upon the introduction of P5+, the PLE spectra demonstrate a sharp reduction in IVCT intensity, i.e., weakening of the quenching channel. The thermal stability of the phosphors at different excitation locations was enhanced with the rise of P5+ concentration. When excited at the 3P2 level, the Y0.995PO4:0.5%Pr3+ phosphor demonstrated highly stable red emission from 303 to 523 K, with a luminescence integrated intensity ranging from 95.5% to 105.3% compared to that at 303 K. This research provides a novel approach for inhibiting the IVCT quenching channel and broadens the commercial value of YVO4:Pr3+ phosphor for various applications.
RESUMO
Herein, a scheme of Sr2+/Ca2+ ion substitution was employed to simultaneously regulate the defect and intervalence charge transfer (IVCT) state of Sr2-xCaxNb2O7:Pr3+ phosphors, resulting in a dual-modulation strategy for enhancing phosphor thermal stability.
RESUMO
The realization of thermally stable Tb3+-doped green emission at high temperatures in solid-state lighting is still a crucial challenge. Nevertheless, the study on modulating the thermally stable luminescence at high temperatures is seldom reported. The position of the intervalence charge transfer (IVCT) energy level is used to systematically investigate the thermal quenching performance of Tb3+-activated green-emitting phosphors with varying concentration gradients of Gd1-xTaO4:xTb3+ (x = 0.1%, 0.5%, and 2%) in this study. The IVCT energy levels were determined according to the empirical formula to show a decreasing trend, consistent with the position of the IVCT energy levels measured in the excitation and diffuse reflectance spectra. Moreover, the thermal quenching performance of different wavelength excitation positions (host absorption, 4f-5d of Tb3+, and Tb3+-Ta5+ IVCT band) is quite different. The modulation of thermal quenching performance among distinct phosphors when subjected to host excitation or IVCT excitation can be elucidated through optimal positions within the energy levels associated with IVCT. The diverse concentration gradient samples exhibit varying degrees of thermal quenching performance in the variable-temperature spectra. The fluorescence lifetimes of the samples are generally comparable but slightly lower. The quantum efficiency rapidly improves as the Tb concentration increases. The underlying mechanism governing this phenomenon is elucidated by constructing a model that encapsulates the interplay between the compensating and quenching channels, in addition to the energy conversion of Tb3+ into Gd3+. The abovementioned results indicate that the dual driving scheme of the doping concentration and excitation wavelength is an effective means to regulate the thermal quenching performance of Tb-activated green-emitting tantalate phosphors.
RESUMO
OBJECTIVE: To explore the impact of the waist circumference change on new onset diabetes (NOD) in the impaired fasting glucose (IFG) population. METHODS: A total of 12 657 subjects who took part in the health examination from 2006 to 2007 and from 2010 to 2011 from the employees of Kailuan Group and met the inclusion criteria were selected as the observation cohort.Of the 12 657 subjects, 10 697 were male, 1960 were female, with age of (49.9 ± 11.3) years old. According to the baseline waist circumference (WC) measurements and its quartile in the health examinations during 2006 to 2007, the observation population was divided into four groups (first, second, third and the fourth quartile groups) . Multiple logistic regression analysis was used to test the relation between the increasing of WC and NOD. RESULTS: The incidences in the IFG population of NOD were 4.27% (1884/12 657) in the total population;4.25% (1581/10 697) in male and 4.44% (303/1960) in females, respectively (P < 0.05) . Along with increasing WC in the 4 quartile groups, the incidences of NOD was progressively increased, which were 2.19% (235/3083) , 3.07% (333/3114) , 4.47% (473/3037) and 7.08% (843/3423) , respectively;2.34% (213/2626) , 3.06% (282/2645) , 4.37% (393/2582), 7.00% (693/2844) in males and 1.38% (22/457) , 3.12% (51/469) , 5.05% (80/455) , 7.45% (150/579) in female (P < 0.05) . Multiple logistic regression analysis showed that compared with the first quartile group, the second, third and fourth quartile group had increased risk of NOD after adjusting for age, gender and other risk factors, the OR (95%CI) values were 1.38(1.13-1.68), 1.79 (1.47-2.09) and 3.10 (2.57-3.75), respectively. CONCLUSION: The incidence of NOD in the IFG population increased as the WC increased.
Assuntos
Glicemia/metabolismo , Diabetes Mellitus Tipo 2/epidemiologia , Intolerância à Glucose/epidemiologia , Circunferência da Cintura , Adulto , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Fatores de RiscoRESUMO
A columnar N-doped graphene aerogel (NGA) was successfully fabricated by one-step hydrothermal synthesis using L-hydroxyproline as reductant, N-doping, and swelling agent, and it was used as the cathode with internal aeration mode for the electro-Fenton degradation of p-nitrophenol. Owing to the stable solid-liquid-gas three-phase interface, more active defects, and modulated nitrogen dopants, the NGA cathode exhibited enhanced electrocatalytic activity. H2O2 could be continuously electro-generated via a two-electron oxygen reduction, and the yield of H2O2 was 153.3 mg·L-1·h-1 with the low electric energy consumption of 15.3 kWh kg-1. Simultaneously, the NGA cathode had better charge transfer capability with N-doping, which was conducive to the conversion of Fe3+/Fe2+. Under the optimal condition, nearly 100% removal of p-nitrophenol and 84% removal of TOC were obtained within 60 and 120 min, respectively. The NGA cathode also presented good stability and versatile applicability in different water matrices. Therefore, the NGA is a cost-effective cathode material in electro-Fenton system with adequate activity and reuse stabilization.
Assuntos
Grafite , Poluentes Químicos da Água , Oxirredução , Peróxido de Hidrogênio , Eletrodos , Poluentes Químicos da Água/análiseRESUMO
This study proposes a new encoding method, also known as an encryption chain based on the measurement result. Then, using the encryption chain to propose a unitary-operation-based semi-quantum key distribution protocol (SQKD) protocol. In the existing SQKD protocols, semi-quantum environments adopt a round-trip transmission strategy. In round-trip transmission, the classical participant must resend the received photons to the quantum participant after implementing local operations. Therefore, round-trip transmissions are vulnerable to Trojan horse attacks. Hence, the classical participant must be equipped with a photon number splitter and an optical wavelength filter device against Trojan horse attacks. This is illogical for semi-quantum environments because the burden on the classical participant is significantly increased as it involves the prevention of Trojan horse attacks. The proposed SQKD protocol is congenitally immune to Trojan horse attacks and involves no extra hardware because it is designed based on a one-way transmission as opposed to a round-trip transmission. When compared to the existing SQKD protocols, the proposed SQKD protocol provides the best qubit efficiency, and classical participants only require two quantum capabilities, which enhance its practicability. Moreover, the proposed SQKD protocol is free from collective attacks, Trojan horse attacks, and intercept-resend attacks. Thus, the proposed scheme is more efficient and practical than the existing SQKD protocols.
RESUMO
The mediated semi-quantum key distribution (MSQKD) protocol is an important research issue that lets two classical participants share secret keys securely between each other with the help of a third party (TP). However, in the existing MSQKD protocols, there are two improvable issues, namely (1) the classical participants must be equipped with expensive detectors to avoid Trojan horse attacks and (2) the trustworthiness level of TP must be honest. To the best of our knowledge, none of the existing MSQKD protocols can resolve both these issues. Therefore, this study takes Bell states as the quantum resource to propose a MSQKD protocol, in which the classical participants do not need a Trojan horse detector and the TP is dishonest. Furthermore, the proposed protocol is shown to be secure against well-known attacks and the classical participants only need two quantum capabilities. Therefore, in comparison to the existing MSQKD protocols, the proposed protocol is better practical.
RESUMO
Aniline is a toxic chemical, and in many industries it is degraded by Fenton processes. In this study, an Fe(II)-nano-Fe3O4@PAC heterogeneous Fenton catalyst (MFC) was prepared with a coprecipitation and impregnation method, which is simple, efficient and cost effective. The results of the magnetic performance tests showed that the MFC has typical ferromagnetism properties. Nano-Fe3O4 was found both on the surface and inside the pores of the powdered activated carbon (PAC). MFC was found to be an efficient catalyst in the Fenton-like process for aniline degradation. The optimal conditions were obtained by the orthogonal experimental method. The results showed that under the optimal conditions (pH = 3.00, temperature = 20°C, concentration of MFC = 1.0â g/L, concentration of H2O2 = 0.27â g/L), the 5â mg/L aniline solution degradation ratio reached 91.2% and the mineralization ratio reached 75.77% in 30â min. In addition, kinetics studies indicated that the aniline degradation process follows a pseudo-first-order kinetics model. No refractory intermediate such as azobenzene, was found during the reaction. The pH value is an important factor in aniline solution degradation. This result indicates that in addition to the surface catalytic reaction, the Fenton reaction also occurs in solution. Fe2+/Fe3+ on the MFC surface and Fe2+/Fe3+ in solution both affect aniline degradation. This catalyst has the advantage of being easily magnetically separated from the aqueous phase. It has useful application prospects in solving organic industrial wastewater pollutions in developing countries because of its cost-effectiveness.
Assuntos
Poluentes Químicos da Água , Água , Compostos de Anilina , Catálise , Carvão Vegetal , Compostos Ferrosos , Peróxido de Hidrogênio , Ferro , PósRESUMO
BACKGROUND: The Traditional Chinese Medicine NiuBeiXiaoHe (NBXH) is a valid antituberculosis (TB) prescription from the experience of clinical practice. However, the mechanism of NBXH extracts' immunotherapy has been poorly understood. Herein, the immunotherapeutic efficacy and the differentially expressed (DE) genes of NBXH extracts were evaluated and identified in BALB/c mice. METHODS: The total RNA was extracted from peripheral blood mononuclear cells, and the DE genes were identified by gene chip. The enrichment and signaling pathway analyses were performed using Gene Ontology (GO) and KEGG database. RESULTS: It was shown that the treatment of NBXH extracts (high dose) significantly reduced mycobacteria loads and histopathological lesions in mice infected by Mycobacterium tuberculosis and resulted in 3,454 DE upregulated genes and 3,594 downregulated DE genes. Furthermore, NBXH extracts killed mycobacteria by inhibiting the supply of necessary ingredients for their growth and proliferation. They restored the disordered immune microenvironments by up- or downregulating immune and inflammation-related pathways. CONCLUSIONS: Taken together, NBXH extracts not only efficiently decreased the mycobacteria loads but also balanced the immune disorders in mice. These new findings provide a fresh perspective for elucidating the immunotherapeutic mechanism of NBXH extracts and pointed out the direction for improving the treatment efficacy of NBXH extracts.