Detalhe da pesquisa
1.
Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell
; 184(4): 943-956.e18, 2021 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-33571432
2.
Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.
Mol Cell
; 83(17): 3171-3187.e7, 2023 09 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37597514
3.
Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature
; 624(7992): 672-681, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37935376
4.
Structure-based identification of a G protein-biased allosteric modulator of cannabinoid receptor CB1.
Proc Natl Acad Sci U S A
; 121(24): e2321532121, 2024 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38830102
5.
Cryo-EM structures of human GPR34 enable the identification of selective antagonists.
Proc Natl Acad Sci U S A
; 120(39): e2308435120, 2023 09 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37733739
6.
Discovery of a Potent and Cell-Active Inhibitor of DNA 6mA Demethylase ALKBH1.
J Am Chem Soc
; 146(10): 6992-7006, 2024 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38437718
7.
Molecular mechanism of allosteric modulation for the cannabinoid receptor CB1.
Nat Chem Biol
; 18(8): 831-840, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35637350
8.
Discovery of α-Ketoamide inhibitors of SARS-CoV-2 main protease derived from quaternized P1 groups.
Bioorg Chem
; 143: 107001, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38101266
9.
Discovery of 5-((1H-indazol-3-yl) methylene)-2-thioxoimidazolidin-4-one derivatives as a new class of AHR agonists with anti-psoriasis activity in a mouse model.
Bioorg Med Chem Lett
; 92: 129383, 2023 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37348572
10.
Discovery of benzodiazepine derivatives as a new class of covalent inhibitors of SARS-CoV-2 main protease.
Bioorg Med Chem Lett
; 92: 129407, 2023 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37437852
11.
Tumor PKCδ instigates immune exclusion in EGFR-mutated non-small cell lung cancer.
BMC Med
; 20(1): 470, 2022 12 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36482371
12.
Discovery of benzo[d]oxazol-2(3H)-one derivatives as a new class of TNIK inhibitors for the treatment of colorectal cancer.
Bioorg Med Chem Lett
; 67: 128745, 2022 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35447345
13.
Discovery of 2-vinyl-10H-phenothiazine derivatives as a class of ferroptosis inhibitors with minimal human Ether-a-go-go related gene (hERG) activity for the treatment of DOX-induced cardiomyopathy.
Bioorg Med Chem Lett
; 74: 128911, 2022 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35907606
14.
Discovery of Small Molecule Agonist of Gonadotropin-Releasing Hormone Receptor (GnRH1R).
J Chem Inf Model
; 62(20): 5009-5022, 2022 Oct 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-36184840
15.
RNA Editing Enzyme ADAR1 Regulates METTL3 in an Editing Dependent Manner to Promote Breast Cancer Progression via METTL3/ARHGAP5/YTHDF1 Axis.
Int J Mol Sci
; 23(17)2022 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-36077054
16.
Discovery of selective BPTF bromodomain inhibitors by screening and structure-based optimization.
Biochem Biophys Res Commun
; 545: 125-131, 2021 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33548625
17.
Discovery of a new class of JMJD6 inhibitors and structure-activity relationship study.
Bioorg Med Chem Lett
; 44: 128109, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33991627
18.
Concepts of Artificial Intelligence for Computer-Assisted Drug Discovery.
Chem Rev
; 119(18): 10520-10594, 2019 09 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-31294972
19.
Structure-Guided Discovery of a Potent and Selective Cell-Active Inhibitor of SETDB1 Tudor Domain.
Angew Chem Int Ed Engl
; 60(16): 8760-8765, 2021 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33511756
20.
Discovery of 5-(4-methylpiperazin-1-yl)-2-nitroaniline derivatives as a new class of SIRT6 inhibitors.
Bioorg Med Chem Lett
; 30(16): 127215, 2020 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32631504