Detalhe da pesquisa
1.
Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma.
Brain
; 146(4): 1697-1713, 2023 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36148553
2.
CN470 is a BET/CBP/p300 multi-bromodomain inhibitor and has an anti-tumor activity against MLL-rearranged acute lymphoblastic leukemia.
Biochem Biophys Res Commun
; 590: 49-54, 2022 01 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-34971957
3.
Retro Drug Design: From Target Properties to Molecular Structures.
J Chem Inf Model
; 62(11): 2659-2669, 2022 06 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35653613
4.
Discovery of endoplasmic reticulum calcium stabilizers to rescue ER-stressed podocytes in nephrotic syndrome.
Proc Natl Acad Sci U S A
; 116(28): 14154-14163, 2019 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31235574
5.
A quinazoline-based bromodomain inhibitor, CN210, ameliorates indomethacin-induced ileitis in mice by inhibiting inflammatory cytokine expression.
Drug Dev Res
; 82(8): 1235-1246, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34075610
6.
Lead optimization and efficacy evaluation of quinazoline-based BET family inhibitors for potential treatment of cancer and inflammatory diseases.
Bioorg Med Chem Lett
; 29(10): 1220-1226, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30905542
7.
Discovery and lead identification of quinazoline-based BRD4 inhibitors.
Bioorg Med Chem Lett
; 28(21): 3483-3488, 2018 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30268702
8.
Synthesis of ß-Substituted Cyclic Enones via Phosphonium Salt-Activated, Palladium-Catalyzed Cross-Coupling of Cyclic 1,3-Diones.
J Org Chem
; 81(8): 3464-9, 2016 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27052958
9.
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs.
Bioorg Med Chem Lett
; 24(5): 1437-41, 2014 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24405703
10.
RALDH1 Inhibition Shows Immunotherapeutic Efficacy in Hepatocellular Carcinoma.
Cancer Immunol Res
; 12(2): 180-194, 2024 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38051215
11.
4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: urea-based analogs.
Bioorg Med Chem Lett
; 23(24): 6773-6, 2013 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24153205
12.
ALDH1A1 promotes PARP inhibitor resistance by enhancing retinoic acid receptor-mediated DNA polymerase θ expression.
NPJ Precis Oncol
; 7(1): 66, 2023 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37429899
13.
Triple combination of BET plus PI3K and NF-κB inhibitors exhibit synergistic activity in adult T-cell leukemia/lymphoma.
Blood Adv
; 6(7): 2346-2360, 2022 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35030628
14.
Discovery of novel Cobactin-T based matrix metalloproteinase inhibitors via a ring closing metathesis strategy.
Bioorg Med Chem Lett
; 21(21): 6485-90, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21925881
15.
A Genome-Edited ERα-HiBiT Fusion Reporter Cell Line for the Identification of ERα Modulators Via High-Throughput Screening and CETSA.
Assay Drug Dev Technol
; 19(8): 539-549, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34662221
16.
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell Rep
; 35(4): 109040, 2021 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33910017
17.
Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.
J Med Chem
; 63(19): 10984-11011, 2020 10 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32902275
18.
beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 1. Design, synthesis, and lead identification.
Bioorg Med Chem Lett
; 18(3): 1135-9, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18086526
19.
Syntheses and in vitro evaluation of arylsulfone-based MMP inhibitors with heterocycle-derived zinc-binding groups (ZBGs).
Bioorg Med Chem Lett
; 18(1): 405-8, 2008 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17980583
20.
beta-N-Biaryl ether sulfonamide hydroxamates as potent gelatinase inhibitors: part 2. Optimization of alpha-amino substituents.
Bioorg Med Chem Lett
; 18(3): 1140-5, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-18083558