Detalhe da pesquisa
1.
Determining tissue distribution of the oral antileishmanial agent miltefosine: a physiologically-based pharmacokinetic modeling approach.
Antimicrob Agents Chemother
; : e0032824, 2024 Jun 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38842325
2.
Antileishmanial Efficacy and Pharmacokinetics of DB766-Azole Combinations.
Antimicrob Agents Chemother
; 62(1)2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29061761
3.
Synthesis and pharmacological evaluation of mono-arylimidamides as antileishmanial agents.
Bioorg Med Chem Lett
; 26(10): 2551-2556, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27048943
4.
Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense.
Bioorg Med Chem
; 24(11): 2451-65, 2016 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27102161
5.
SAR refinement of antileishmanial N(2),N(4)-disubstituted quinazoline-2,4-diamines.
Bioorg Med Chem
; 23(16): 5182-9, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25749014
6.
A simple and sensitive assay for eflornithine quantification in rat brain using pre-column derivatization and UPLC-MS/MS detection.
Biomed Chromatogr
; 29(6): 918-24, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25365958
7.
Pharmacokinetic comparison to determine the mechanisms underlying the differential efficacies of cationic diamidines against first- and second-stage human African trypanosomiasis.
Antimicrob Agents Chemother
; 58(7): 4064-74, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24798280
8.
In vitro and in vivo evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness.
Antimicrob Agents Chemother
; 58(8): 4452-63, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24867978
9.
Pharmacokinetics of drugs in spontaneously or secondary hypertensive rats.
Xenobiotica
; 44(1): 77-88, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23808362
10.
Pharmacokinetics, Trypanosoma brucei gambiense efficacy, and time of drug action of DB829, a preclinical candidate for treatment of second-stage human African trypanosomiasis.
Antimicrob Agents Chemother
; 57(11): 5330-43, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23959303
11.
Synthesis and antiprotozoal activity of dicationic 2,6-diphenylpyrazines and aza-analogues.
Bioorg Med Chem
; 21(21): 6732-41, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24012380
12.
Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: in vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies.
Antimicrob Agents Chemother
; 56(7): 3690-9, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22508306
13.
Metopimazine is primarily metabolized by a liver amidase in humans.
Pharmacol Res Perspect
; 10(1): e00903, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34918875
14.
Sterol profiling of Leishmania parasites using a new HPLC-tandem mass spectrometry-based method and antifungal azoles as chemical probes reveals a key intermediate sterol that supports a branched ergosterol biosynthetic pathway.
Int J Parasitol Drugs Drug Resist
; 20: 27-42, 2022 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-35994895
15.
Effects of ticlopidine on pharmacokinetics of losartan and its main metabolite EXP-3174 in rats.
Acta Pharmacol Sin
; 32(7): 967-72, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21666702
16.
Effects of HMG-CoA reductase inhibitors on the pharmacokinetics of losartan and its main metabolite EXP-3174 in rats: possible role of CYP3A4 and P-gp inhibition by HMG-CoA reductase inhibitors.
Pharmacology
; 88(1-2): 1-9, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21709429
17.
Improving Eflornithine Oral Bioavailability and Brain Uptake by Modulating Intercellular Junctions With an E-cadherin Peptide.
J Pharm Sci
; 108(12): 3870-3878, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31545969
18.
The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models.
Br J Pharmacol
; 174(15): 2576-2590, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28542844
19.
CYP1A1 and CYP1B1-mediated biotransformation of the antitrypanosomal methamidoxime prodrug DB844 forms novel metabolites through intramolecular rearrangement.
J Pharm Sci
; 103(1): 337-49, 2014 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-24186380
20.
Antileishmanial activity of a series of N²,N4-disubstituted quinazoline-2,4-diamines.
J Med Chem
; 57(12): 5141-56, 2014 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24874647